3hpt B 2.19 BS01 YET B 1 T98 Y99 F174 A190 Q192 V213 W215 G216 G218 C220 G226 Y228 T84 Y85 F162 A180 Q182 V203 W205 G206 G208 C209 G216 Y218 H57 D102 Q192 G193 D194 S195 G196 H42 D88 Q182 G183 D184 S185 G186 3.4.21.6 0004252,0006508 Ki=6.5nM -logKd/Ki=8.19, Ki=6.5nM IC50=12nM, Ki=6.5nM P00742 19541481 1 IVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLP 3hpt B 2.19 BS02 CA B 1 D70 N72 T73 Q75 E80 D56 N58 T59 Q61 E66 H57 D102 Q192 G193 D194 S195 G196 H42 D88 Q182 G183 D184 S185 G186 3.4.21.6 0004252,0006508 P00742 19541481 249 IVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLP 3hpt D 2.19 BS01 YET D 1 T98 Y99 F174 A190 Q192 V213 W215 G216 G218 C220 G226 I227 Y228 T84 Y85 F161 A179 Q181 V202 W204 G205 G207 C208 G215 I216 Y217 H57 D102 Q192 G193 D194 S195 G196 H42 D88 Q181 G182 D183 S184 G185 3.4.21.6 0004252,0006508 Ki=6.5nM IC50=12nM, Ki=6.5nM P00742 19541481 2 IVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLP 3hpt D 2.19 BS02 CA D 1 D70 N72 Q75 E80 D56 N58 Q61 E66 H57 D102 Q192 G193 D194 S195 G196 H42 D88 Q181 G182 D183 S184 G185 3.4.21.6 0004252,0006508 P00742 19541481 249 IVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLP