3h4v A 2.4 BS01 NAP A 1 R17 L18 H36 Y37 H38 R39 S40 L66 N109 A110 S111 S112 M179 V180 K198 P224 L226 S227 R13 L14 H32 Y33 H34 R35 S36 L62 N103 A104 S105 S106 M164 V165 K183 P209 L211 S212 R17 D181 Y194 R13 D166 Y179 1.5.1.33 0004155,0005829,0006729,0016491,0031427,0047040 Q01782 18245389 300 TVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLSNVATAPVADGSAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLRNGDREAMETATADLFGSNAIAPYFLIKAFAHRVAGTPAKHRGTNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDMPPAVWEGHRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA 3h4v A 2.4 BS02 DVP A 1 S111 F113 L188 Y194 L226 S105 F107 L173 Y179 L211 R17 D181 Y194 R13 D166 Y179 1.5.1.33 0004155,0005829,0006729,0016491,0031427,0047040 Ki=0.1uM Ki=100nM Q01782 18245389 301 TVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLSNVATAPVADGSAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLRNGDREAMETATADLFGSNAIAPYFLIKAFAHRVAGTPAKHRGTNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDMPPAVWEGHRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA 3h4v B 2.4 BS01 NAP B 1 R17 L18 H36 Y37 H38 R39 S40 L66 N109 A110 S111 S112 S146 M179 V180 K198 P224 S227 R13 L14 H32 Y33 H34 R35 S36 L62 N104 A105 S106 S107 S131 M164 V165 K183 P209 S212 R17 D181 Y194 R13 D166 Y179 1.5.1.33 0004155,0005829,0006729,0016491,0031427,0047040 Q01782 18245389 300 TVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLSNVATAPVGADGSAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLRGDREAMETATADLFGSNAIAPYFLIKAFAHRVAGTPAKHRGTNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDMPPAVWEGHRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA 3h4v B 2.4 BS02 DVP B 1 S111 F113 Y194 L226 S106 F108 Y179 L211 R17 D181 Y194 R13 D166 Y179 1.5.1.33 0004155,0005829,0006729,0016491,0031427,0047040 Ki=0.1uM Ki=100nM Q01782 18245389 301 TVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLSNVATAPVGADGSAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLRGDREAMETATADLFGSNAIAPYFLIKAFAHRVAGTPAKHRGTNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDMPPAVWEGHRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA 3h4v C 2.4 BS01 NAP C 1 R17 L18 H36 Y37 H38 R39 S40 L66 N109 A110 S111 S112 M179 V180 D181 K198 P224 S227 R12 L13 H31 Y32 H33 R34 S35 L61 N98 A99 S100 S101 M158 V159 D160 K177 P203 S206 R17 D181 Y194 R12 D160 Y173 1.5.1.33 0004155,0005829,0006729,0016491,0031427,0047040 Q01782 18245389 300 VPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLSNVATAPSAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLRNDREAMETATADLFGSNAIAPYFLIKAFAHRVAGTPAKHRGTNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVEGHRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA 3h4v C 2.4 BS02 DVP C 1 S111 F113 L188 Y194 H241 S100 F102 L167 Y173 H212 R17 D181 Y194 R12 D160 Y173 1.5.1.33 0004155,0005829,0006729,0016491,0031427,0047040 Ki=0.1uM Ki=100nM Q01782 18245389 301 VPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLSNVATAPSAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLRNDREAMETATADLFGSNAIAPYFLIKAFAHRVAGTPAKHRGTNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVEGHRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA 3h4v D 2.4 BS01 NAP D 1 R17 L18 H36 Y37 H38 R39 S40 L66 N109 A110 S111 S112 D142 M179 V180 D181 K198 P224 L226 S227 R13 L14 H32 Y33 H34 R35 S36 L62 N99 A100 S101 S102 D120 M157 V158 D159 K176 P202 L204 S205 R17 D181 Y194 R13 D159 Y172 1.5.1.33 0004155,0005829,0006729,0016491,0031427,0047040 Q01782 18245389 300 TVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLSNVATAPVAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLRREAMETATADLFGSNAIAPYFLIKAFAHRVAGTPAKHRGTNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDMVWEGHRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA 3h4v D 2.4 BS02 DVP D 1 S111 F113 L188 Y194 S101 F103 L166 Y172 R17 D181 Y194 R13 D159 Y172 1.5.1.33 0004155,0005829,0006729,0016491,0031427,0047040 Ki=0.1uM Ki=100nM Q01782 18245389 301 TVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLSNVATAPVAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLRREAMETATADLFGSNAIAPYFLIKAFAHRVAGTPAKHRGTNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDMVWEGHRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA 3h4v E 2.4 BS01 NAP E 1 R17 L18 H36 Y37 H38 R39 S40 L66 N109 A110 S111 S112 M179 V180 K198 P224 S227 R12 L13 H31 Y32 H33 R34 S35 L61 N97 A98 S99 S100 M157 V158 K176 P202 S205 R17 D181 Y194 R12 D159 Y172 1.5.1.33 0004155,0005829,0006729,0016491,0031427,0047040 Q01782 18245389 300 VPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLSNVATAPAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLRGDREAMETATADLFGSNAIAPYFLIKAFAHRVAGTPAKHRGTNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDMPPAVWEGHRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA 3h4v E 2.4 BS02 DVP E 1 S111 F113 L188 Y194 S99 F101 L166 Y172 R17 D181 Y194 R12 D159 Y172 1.5.1.33 0004155,0005829,0006729,0016491,0031427,0047040 Ki=0.1uM Ki=100nM Q01782 18245389 301 VPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLSNVATAPAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLRGDREAMETATADLFGSNAIAPYFLIKAFAHRVAGTPAKHRGTNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDMPPAVWEGHRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA 3h4v F 2.4 BS01 NAP F 1 R17 L18 H36 Y37 H38 R39 S40 L66 N109 A110 S111 S112 M179 V180 D181 K198 P224 L226 S227 R13 L14 H32 Y33 H34 R35 S36 L62 N99 A100 S101 S102 M161 V162 D163 K180 P206 L208 S209 R17 D181 Y194 R13 D163 Y176 1.5.1.33 0004155,0005829,0006729,0016491,0031427,0047040 Q01782 18245389 300 TVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLSNVATAPSAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLRNDGDREAMETATADLFGSNAIAPYFLIKAFAHRVAGTPAKHRGTNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDMPPAVWEGHRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA 3h4v F 2.4 BS02 DVP F 1 S111 F113 L188 Y191 Y194 S101 F103 L170 Y173 Y176 R17 D181 Y194 R13 D163 Y176 1.5.1.33 0004155,0005829,0006729,0016491,0031427,0047040 Ki=0.1uM Ki=100nM Q01782 18245389 301 TVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLSNVATAPSAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLRNDGDREAMETATADLFGSNAIAPYFLIKAFAHRVAGTPAKHRGTNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDMPPAVWEGHRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA 3h4v G 2.4 BS01 NAP G 1 R17 L18 Y37 H38 R39 S40 D65 L66 N109 S111 D142 M179 V180 D181 K198 S227 R12 L13 Y32 H33 R34 S35 D60 L61 N97 S99 D120 M157 V158 D159 K176 S205 R17 D181 Y194 R12 D159 Y172 1.5.1.33 0004155,0005829,0006729,0016491,0031427,0047040 Q01782 18245389 300 VPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLSNVATAPAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLRNDREAMETATADLFGSNAIAPYFLIKAFAHRVAGTPAKHRGTNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDMEGHRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA 3h4v G 2.4 BS02 DVP G 1 S111 F113 L188 Y194 L226 S99 F101 L166 Y172 L204 R17 D181 Y194 R12 D159 Y172 1.5.1.33 0004155,0005829,0006729,0016491,0031427,0047040 Ki=0.1uM Ki=100nM Q01782 18245389 301 VPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLSNVATAPAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLRNDREAMETATADLFGSNAIAPYFLIKAFAHRVAGTPAKHRGTNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDMEGHRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA 3h4v H 2.4 BS01 NAP H 1 R17 L18 H38 R39 S40 L66 S67 N109 S111 S112 S146 V180 D181 Y194 K198 P224 G225 L226 S227 R13 L14 H34 R35 S36 L62 S63 N98 S100 S101 S127 V161 D162 Y175 K179 P205 G206 L207 S208 R17 D181 Y194 R13 D162 Y175 1.5.1.33 0004155,0005829,0006729,0016491,0031427,0047040 Q01782 18245389 300 TVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLSNVATAPAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLRNDGDREAMETATADLFGSNAIAPYFLIKAFAHRVAGTPAKHRGTNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDEGHRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA 3h4v H 2.4 BS02 DVP H 1 S111 F113 L188 Y194 L229 D232 H241 S100 F102 L169 Y175 L210 D213 H216 R17 D181 Y194 R13 D162 Y175 1.5.1.33 0004155,0005829,0006729,0016491,0031427,0047040 Ki=0.1uM Ki=100nM Q01782 18245389 301 TVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLSNVATAPAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLRNDGDREAMETATADLFGSNAIAPYFLIKAFAHRVAGTPAKHRGTNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDEGHRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA