3h30 A 1.56 BS01 RFZ A 1 V53 N118 M163 I174 V52 N117 M162 I173 D156 K158 N161 D175 P184 S194 D155 K157 N160 D174 P183 S193 2.7.11.1 0004672,0004674,0005524,0006468 Ki=29.2uM -logKd/Ki=4.53, Ki=29.2uM Ki=4500nM, IC50=13000nM P68400 18291315 336 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARM 3h30 A 1.56 BS02 RFZ A 2 Q40 I69 P104 Q39 I68 P103 D156 K158 N161 D175 P184 S194 D155 K157 N160 D174 P183 S193 2.7.11.1 0004672,0004674,0005524,0006468 Ki=29.2uM -logKd/Ki=4.53, Ki=29.2uM Ki=4500nM, IC50=13000nM P68400 18291315 337 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARM 3h30 B 1.56 BS01 RFZ B 1 G46 R47 G48 V53 V116 N118 I174 G45 R46 G47 V52 V115 N117 I173 D156 K158 N161 D175 P184 S194 D155 K157 N160 D174 P183 S193 2.7.11.1 0004672,0004674,0005524,0006468 Ki=29.2uM Ki=4500nM, IC50=13000nM P68400 18291315 336 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARM