3gzn B 3.0 BS01 ZN B 1 C223 C364 C367 C191 C332 C335 K42 D167 C237 T238 A240 K10 D135 C205 T206 A208 6.2.1.64 0000278,0005515,0005524,0005634,0005737,0005829,0006508,0007113,0008641,0016874,0019781,0019788,0032991,0036211,0042802,0043687,0045116,0046982,0051726 Q8TBC4 20129059 465 DWEGRWNHVKKFLERSGPFTHPDFEPSTESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAEVAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLISLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIASMPRLPEHCIEYVRMLQWPKEQPFGEGVPLDGDDPEHIQWIFQKSLERASQYNIRGVTYRLTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAERKENCPACSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVTSIEERTRPNLSKLKELGLVDGQELAVADVTTPQTVLFKLHFT 3gzn B 3.0 BS02 B39 I 1 G78 G79 D100 M101 D102 K147 I148 Q149 L166 D167 A171 W174 G46 G47 D68 M69 D70 K115 I116 Q117 L134 D135 A139 W142 K42 D167 C237 T238 A240 K10 D135 C205 T206 A208 6.2.1.64 0000278,0005515,0005524,0005634,0005737,0005829,0006508,0007113,0008641,0016874,0019781,0019788,0032991,0036211,0042802,0043687,0045116,0046982,0051726 -logKd/Ki=8.00, IC50=10nM IC50=5.0nM Q8TBC4 20129059 464 DWEGRWNHVKKFLERSGPFTHPDFEPSTESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAEVAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLISLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIASMPRLPEHCIEYVRMLQWPKEQPFGEGVPLDGDDPEHIQWIFQKSLERASQYNIRGVTYRLTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAERKENCPACSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVTSIEERTRPNLSKLKELGLVDGQELAVADVTTPQTVLFKLHFT 3gzn D 3.0 BS01 ZN D 1 C223 C364 C367 C191 C332 C335 K42 D167 C237 T238 A240 K10 D135 C205 T206 A208 6.2.1.64 0000278,0005515,0005524,0005634,0005737,0005829,0006508,0007113,0008641,0016874,0019781,0019788,0032991,0036211,0042802,0043687,0045116,0046982,0051726 Q8TBC4 20129059 465 DWEGRWNHVKKFLERSGPFTHPDFEPSTESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAEVAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLISLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIASMPRLPEHCIEYVRMLQWPKEQPFGEGVPLDGDDPEHIQWIFQKSLERASQYNIRGVTYRLTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAERKENCPACSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVTSIEERTRPNLSKLKELGLVDGQELAVADVTTPQTVLFKLHFT 3gzn D 3.0 BS02 B39 J 1 G78 D100 M101 K124 K147 I148 Q149 L166 D167 A171 W174 G46 D68 M69 K92 K115 I116 Q117 L134 D135 A139 W142 K42 D167 C237 T238 A240 K10 D135 C205 T206 A208 6.2.1.64 0000278,0005515,0005524,0005634,0005737,0005829,0006508,0007113,0008641,0016874,0019781,0019788,0032991,0036211,0042802,0043687,0045116,0046982,0051726 IC50=5.0nM Q8TBC4 20129059 464 DWEGRWNHVKKFLERSGPFTHPDFEPSTESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAEVAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLISLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIASMPRLPEHCIEYVRMLQWPKEQPFGEGVPLDGDDPEHIQWIFQKSLERASQYNIRGVTYRLTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAERKENCPACSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVTSIEERTRPNLSKLKELGLVDGQELAVADVTTPQTVLFKLHFT