3gug A 1.9 BS01 NAP A 1 G22 T23 Y24 D50 Y55 H117 Q190 Y216 S217 L219 S221 H222 A253 L268 K270 S271 R276 Q279 N280 G17 T18 Y19 D45 Y50 H112 Q185 Y211 S212 L214 S216 H217 A248 L263 K265 S266 R271 Q274 N275 D50 Y55 K84 H117 D45 Y50 K79 H112 1.1.1.-,1.1.1.112,1.1.1.149,1.1.1.209,1.1.1.210,1.1.1.357,1.1.1.51,1.1.1.53,1.1.1.62,1.3.1.20 0001523,0004032,0004033,0004303,0005515,0005737,0005829,0006629,0006693,0006805,0007586,0008206,0015721,0016491,0016655,0030283,0030299,0030855,0031406,0032052,0033703,0033764,0035410,0042448,0042574,0042632,0044597,0044598,0046683,0047006,0047023,0047024,0047042,0047044,0047045,0047086,0047115,0047718,0070062,0071395,2000379 Q04828 350 QCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTVDIFAGPPNYPFSDEY 3gug A 1.9 BS02 C2U A 1 Y24 L54 Y55 H117 H222 W227 L306 Y19 L49 Y50 H112 H217 W222 L301 D50 Y55 K84 H117 D45 Y50 K79 H112 1.1.1.-,1.1.1.112,1.1.1.149,1.1.1.209,1.1.1.210,1.1.1.357,1.1.1.51,1.1.1.53,1.1.1.62,1.3.1.20 0001523,0004032,0004033,0004303,0005515,0005737,0005829,0006629,0006693,0006805,0007586,0008206,0015721,0016491,0016655,0030283,0030299,0030855,0031406,0032052,0033703,0033764,0035410,0042448,0042574,0042632,0044597,0044598,0046683,0047006,0047023,0047024,0047042,0047044,0047045,0047086,0047115,0047718,0070062,0071395,2000379 Ki=5.9nM, IC50=6nM Q04828 351 QCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTVDIFAGPPNYPFSDEY 3gug A 1.9 BS03 ZN A 1 H248 E292 H243 E287 D50 Y55 K84 H117 D45 Y50 K79 H112 1.1.1.-,1.1.1.112,1.1.1.149,1.1.1.209,1.1.1.210,1.1.1.357,1.1.1.51,1.1.1.53,1.1.1.62,1.3.1.20 0001523,0004032,0004033,0004303,0005515,0005737,0005829,0006629,0006693,0006805,0007586,0008206,0015721,0016491,0016655,0030283,0030299,0030855,0031406,0032052,0033703,0033764,0035410,0042448,0042574,0042632,0044597,0044598,0046683,0047006,0047023,0047024,0047042,0047044,0047045,0047086,0047115,0047718,0070062,0071395,2000379 Q04828 324 QCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTVDIFAGPPNYPFSDEY