3gr6 A 2.28 BS01 NAP A 1 G13 I14 A15 S19 I20 R40 K41 S44 D66 V67 S93 I94 A95 T145 T146 Y147 K164 P192 I193 T195 S197 G12 I13 A14 S18 I19 R39 K40 S43 D65 V66 S92 I93 A94 T144 T145 Y146 K163 P191 I192 T194 S196 Y147 Y157 M160 K164 K199 Y146 Y156 M159 K163 K198 1.3.1.39 0000166,0004318,0006633,0016491,0030497,0042802,0050661,0141148 Kd=18.6uM Q6GI75 19768684 361 LNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK 3gr6 A 2.28 BS02 TCL A 1 A97 Y147 Y157 M160 S197 A198 V201 F204 A96 Y146 Y156 M159 S196 A197 V200 F203 Y147 Y157 M160 K164 K199 Y146 Y156 M159 K163 K198 1.3.1.39 0000166,0004318,0006633,0016491,0030497,0042802,0050661,0141148 Kd=2.92nM IC50=70nM, Ki=0.05nM Q6GI75 19768684 371 LNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK 3gr6 D 2.28 BS01 NAP D 1 G13 A15 S19 I20 R40 K41 S44 D66 V67 S93 I94 A95 T145 T146 Y147 K164 G191 P192 I193 T195 S197 G17 A19 S23 I24 R44 K45 S48 D70 V71 S97 I98 A99 T149 T150 Y151 K168 G195 P196 I197 T199 S201 Y147 Y157 M160 K164 K199 Y151 Y161 M164 K168 K203 1.3.1.39 0000166,0004318,0006633,0016491,0030497,0042802,0050661,0141148 Kd=18.6uM Q6GI75 19768684 257 LAAAMLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK 3gr6 D 2.28 BS02 TCL D 1 F96 A97 Y147 Y157 M160 S197 V201 F100 A101 Y151 Y161 M164 S201 V205 Y147 Y157 M160 K164 K199 Y151 Y161 M164 K168 K203 1.3.1.39 0000166,0004318,0006633,0016491,0030497,0042802,0050661,0141148 Kd=2.92nM IC50=70nM, Ki=0.05nM Q6GI75 19768684 258 LAAAMLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK 3gr6 G 2.28 BS01 NAP G 1 G13 S19 I20 R40 D66 V67 S93 I94 A95 T145 T146 Y147 K164 A190 I193 T195 S197 G11 S17 I18 R38 D64 V65 S91 I92 A93 T143 T144 Y145 K162 A188 I191 T193 S195 1.3.1.39 0000166,0004318,0006633,0016491,0030497,0042802,0050661,0141148 Kd=18.6uM Q6GI75 19768684 257 NLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK 3gr6 G 2.28 BS02 TCL G 1 A95 F96 A97 Y147 Y157 M160 S197 A198 V201 F204 A93 F94 A95 Y145 Y155 M158 S195 A196 V199 F202 1.3.1.39 0000166,0004318,0006633,0016491,0030497,0042802,0050661,0141148 Kd=2.92nM IC50=70nM, Ki=0.05nM Q6GI75 19768684 258 NLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK 3gr6 J 2.28 BS01 NAP J 1 G13 S19 I20 R40 K41 D66 V67 S93 I94 A95 T145 T146 Y147 K164 A190 G191 I193 T195 S197 G17 S23 I24 R44 K45 D70 V71 S97 I98 A99 T149 T150 Y151 K168 A194 G195 I197 T199 S201 1.3.1.39 0000166,0004318,0006633,0016491,0030497,0042802,0050661,0141148 Kd=18.6uM Q6GI75 19768684 257 LAAAMLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK 3gr6 J 2.28 BS02 TCL J 1 A97 Y147 Y157 M160 S197 A198 V201 F204 A101 Y151 Y161 M164 S201 A202 V205 F208 1.3.1.39 0000166,0004318,0006633,0016491,0030497,0042802,0050661,0141148 Kd=2.92nM IC50=70nM, Ki=0.05nM Q6GI75 19768684 258 LAAAMLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK