3gpo A 1.9 BS01 APR A 1 D10 I11 N24 G30 D31 G32 V33 C34 L108 S110 T111 G112 V113 Y114 R144 D12 I13 N26 G32 D33 G34 V35 C36 L110 S112 T113 G114 V115 Y116 R146 2.1.1.-,2.7.7.-,2.7.7.19,2.7.7.48,3.1.3.84,3.4.22.-,3.6.1.15,3.6.1.74,3.6.4.13 Kd=5uM -logKd/Ki=5.30, Kd=5uM Q8JUX6 19386706 161 HHAPSYRVKRMDIAKNDEECVVNAANPRGLPGDGVCKAVYKKWPESFKNSATPVGTAKTVMCGTYPVIHAVGPNFSNYSESEGDRELAAAYREVAKEVTRLGVNSVAIPLLSTGVYSGGKDRLTQSLNHLFTAMDSTDADVVIYCRDKEWEKKISEAIQMRT 3gpo B 1.9 BS01 APR B 1 D10 I11 A22 D31 G32 V33 L108 S110 T111 G112 V113 Y114 R144 D10 I11 A22 D31 G32 V33 L108 S110 T111 G112 V113 Y114 R144 2.1.1.-,2.7.7.-,2.7.7.19,2.7.7.48,3.1.3.84,3.4.22.-,3.6.1.15,3.6.1.74,3.6.4.13 Kd=5uM Q8JUX6 19386706 161 APSYRVKRMDIAKNDEECVVNAANPRGLPGDGVCKAVYKKWPESFKNSATPVGTAKTVMCGTYPVIHAVGPNFSNYSESEGDRELAAAYREVAKEVTRLGVNSVAIPLLSTGVYSGGKDRLTQSLNHLFTAMDSTDADVVIYCRDKEWEKKISEAIQMRT 3gpo C 1.9 BS01 APR C 1 D10 I11 A22 N24 G30 D31 G32 V33 L108 S110 T111 G112 V113 Y114 R144 D10 I11 A22 N24 G30 D31 G32 V33 L108 S110 T111 G112 V113 Y114 R144 2.1.1.-,2.7.7.-,2.7.7.19,2.7.7.48,3.1.3.84,3.4.22.-,3.6.1.15,3.6.1.74,3.6.4.13 Kd=5uM Q8JUX6 19386706 161 APSYRVKRMDIAKNDEECVVNAANPRGLPGDGVCKAVYKKWPESFKNSATPVGTAKTVMCGTYPVIHAVGPNFSNYSESEGDRELAAAYREVAKEVTRLGVNSVAIPLLSTGVYSGGKDRLTQSLNHLFTAMDSTDADVVIYCRDKEWEKKISEAIQMRT 3gpo D 1.9 BS01 APR D 1 D10 I11 A22 N24 G30 D31 G32 V33 C34 L108 S110 T111 G112 V113 Y114 R144 D9 I10 A21 N23 G29 D30 G31 V32 C33 L107 S109 T110 G111 V112 Y113 R143 2.1.1.-,2.7.7.-,2.7.7.19,2.7.7.48,3.1.3.84,3.4.22.-,3.6.1.15,3.6.1.74,3.6.4.13 Kd=5uM Q8JUX6 19386706 161 PSYRVKRMDIAKNDEECVVNAANPRGLPGDGVCKAVYKKWPESFKNSATPVGTAKTVMCGTYPVIHAVGPNFSNYSESEGDRELAAAYREVAKEVTRLGVNSVAIPLLSTGVYSGGKDRLTQSLNHLFTAMDSTDADVVIYCRDKEWEKKISEAIQMR