3gok A 3.2 BS01 P4O A 1 L70 L72 G73 V78 K93 C140 L141 D142 L193 T206 D207 L25 L27 G28 V33 K48 C95 L96 D97 L146 T159 D160 D186 K188 E190 N191 D207 D139 K141 E143 N144 D160 2.7.11.1 0004672,0005524,0006468 IC50=8.5nM, EC50=49nM P49137 1 FHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNSPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWE 3gok B 3.2 BS01 P4O B 1 L70 G73 V78 A91 K93 C140 L141 D142 L193 D207 L25 G28 V33 A46 K48 C95 L96 D97 L148 D162 D186 K188 E190 N191 D207 D141 K143 E145 N146 D162 2.7.11.1 0004672,0005524,0006468 IC50=8.5nM, EC50=49nM P49137 1 FHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWE 3gok C 3.2 BS01 P4O C 1 L70 L72 G73 V78 A91 K93 L141 D142 L193 D207 L25 L27 G28 V33 A46 K48 L96 D97 L146 D160 D186 K188 E190 N191 D207 D139 K141 E143 N144 D160 2.7.11.1 0004672,0005524,0006468 IC50=8.5nM, EC50=49nM P49137 1 FHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWE 3gok D 3.2 BS01 P4O D 1 L70 L72 G73 V78 K93 C140 L141 D142 L193 T206 D207 L25 L27 G28 V33 K48 C95 L96 D97 L146 T159 D160 D186 K188 E190 N191 D207 D139 K141 E143 N144 D160 2.7.11.1 0004672,0005524,0006468 IC50=8.5nM, EC50=49nM P49137 1 FHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNSPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWE 3gok E 3.2 BS01 P4O E 1 L70 G73 V78 K93 C140 L141 D142 L193 D207 L25 G28 V33 K48 C95 L96 D97 L148 D162 D186 K188 E190 N191 D207 D141 K143 E145 N146 D162 2.7.11.1 0004672,0005524,0006468 IC50=8.5nM, EC50=49nM P49137 1 FHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWE 3gok F 3.2 BS01 P4O F 1 L70 L72 G73 V78 A91 K93 C140 L141 D142 L193 D207 L25 L27 G28 V33 A46 K48 C95 L96 D97 L146 D160 D186 K188 E190 N191 D207 D139 K141 E143 N144 D160 2.7.11.1 0004672,0005524,0006468 IC50=8.5nM, EC50=49nM P49137 1 FHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWE 3gok G 3.2 BS01 P4O G 1 L70 G73 K93 C140 L141 D142 L193 T206 D207 L25 G28 K48 C95 L96 D97 L146 T159 D160 D186 K188 E190 N191 D207 D139 K141 E143 N144 D160 2.7.11.1 0004672,0005524,0006468 IC50=8.5nM, EC50=49nM P49137 1 FHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNSPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWE 3gok H 3.2 BS01 P4O H 1 L70 V78 A91 K93 L141 D142 L193 D207 L25 V33 A46 K48 L96 D97 L148 D162 D186 K188 E190 N191 D207 D141 K143 E145 N146 D162 2.7.11.1 0004672,0005524,0006468 IC50=8.5nM, EC50=49nM P49137 1 FHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWE 3gok I 3.2 BS01 P4O I 1 L70 L72 G73 V78 A91 K93 C140 L141 D142 L193 D207 L25 L27 G28 V33 A46 K48 C95 L96 D97 L146 D160 D186 K188 E190 N191 D207 D139 K141 E143 N144 D160 2.7.11.1 0004672,0005524,0006468 IC50=8.5nM, EC50=49nM P49137 1 FHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWE 3gok J 3.2 BS01 P4O J 1 L70 G73 V78 A91 K93 C140 L141 D142 L193 D207 L25 G28 V33 A46 K48 C95 L96 D97 L146 D160 D186 K188 E190 N191 D207 D139 K141 E143 N144 D160 2.7.11.1 0004672,0005524,0006468 IC50=8.5nM, EC50=49nM P49137 1 FHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNSPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWE 3gok K 3.2 BS01 P4O K 1 L70 G73 K93 L141 D142 G144 L193 T206 D207 L25 G28 K48 L96 D97 G99 L148 T161 D162 D186 K188 E190 N191 D207 D141 K143 E145 N146 D162 2.7.11.1 0004672,0005524,0006468 IC50=8.5nM, EC50=49nM P49137 1 FHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWE 3gok L 3.2 BS01 P4O L 1 L70 L72 G73 V78 K93 L141 D142 L193 D207 L25 L27 G28 V33 K48 L96 D97 L146 D160 D186 K188 E190 N191 D207 D139 K141 E143 N144 D160 2.7.11.1 0004672,0005524,0006468 IC50=8.5nM, EC50=49nM P49137 1 FHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWE