3g3e A 2.2 BS01 FAD A 1 G7 G9 V10 I11 A36 D37 R38 T44 T45 A48 G50 L51 V164 T182 W185 R283 G312 G313 Y314 G315 L316 T317 G7 G9 V10 I11 A36 D37 R38 T44 T45 A48 G50 L51 V164 T182 W185 R283 G312 G313 Y314 G315 L316 T317 L51 G313 T317 L51 G313 T317 1.4.3.3 0003884,0005515,0005576,0005737,0005741,0005777,0005782,0005829,0006562,0007586,0016491,0019478,0036088,0042416,0042802,0042995,0045202,0046416,0048786,0055130,0070178,0070945,0071949 P14920 19438227 352 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLS 3g3e A 2.2 BS02 G3E A 1 Y224 Y228 R283 G313 Y224 Y228 R283 G313 L51 G313 T317 L51 G313 T317 1.4.3.3 0003884,0005515,0005576,0005737,0005741,0005777,0005782,0005829,0006562,0007586,0016491,0019478,0036088,0042416,0042802,0042995,0045202,0046416,0048786,0055130,0070178,0070945,0071949 ic50=4nM IC50=4nM, Kd=13nM P14920 19438227 353 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLS 3g3e B 2.2 BS01 FAD B 1 G7 G9 V10 I11 A36 D37 R38 T44 T45 A48 G50 L51 K163 V164 T182 W185 R283 G312 G313 Y314 G315 L316 T317 G7 G9 V10 I11 A36 D37 R38 T44 T45 A48 G50 L51 K163 V164 T182 W185 R283 G312 G313 Y314 G315 L316 T317 L51 G313 T317 L51 G313 T317 1.4.3.3 0003884,0005515,0005576,0005737,0005741,0005777,0005782,0005829,0006562,0007586,0016491,0019478,0036088,0042416,0042802,0042995,0045202,0046416,0048786,0055130,0070178,0070945,0071949 P14920 19438227 352 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLS 3g3e B 2.2 BS02 G3E B 1 Y224 Y228 R283 G313 Y224 Y228 R283 G313 L51 G313 T317 L51 G313 T317 1.4.3.3 0003884,0005515,0005576,0005737,0005741,0005777,0005782,0005829,0006562,0007586,0016491,0019478,0036088,0042416,0042802,0042995,0045202,0046416,0048786,0055130,0070178,0070945,0071949 ic50=4nM IC50=4nM, Kd=13nM P14920 19438227 353 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLS 3g3e C 2.2 BS01 FAD C 1 G7 G9 V10 I11 A36 D37 R38 T44 T45 A48 G50 L51 K163 V164 T182 W185 R283 G312 G313 Y314 G315 L316 T317 G7 G9 V10 I11 A36 D37 R38 T44 T45 A48 G50 L51 K163 V164 T182 W185 R283 G312 G313 Y314 G315 L316 T317 L51 G313 T317 L51 G313 T317 1.4.3.3 0003884,0005515,0005576,0005737,0005741,0005777,0005782,0005829,0006562,0007586,0016491,0019478,0036088,0042416,0042802,0042995,0045202,0046416,0048786,0055130,0070178,0070945,0071949 P14920 19438227 352 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLS 3g3e C 2.2 BS02 G3E C 1 Y224 Y228 R283 G313 Y224 Y228 R283 G313 L51 G313 T317 L51 G313 T317 1.4.3.3 0003884,0005515,0005576,0005737,0005741,0005777,0005782,0005829,0006562,0007586,0016491,0019478,0036088,0042416,0042802,0042995,0045202,0046416,0048786,0055130,0070178,0070945,0071949 ic50=4nM IC50=4nM, Kd=13nM P14920 19438227 353 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLS 3g3e D 2.2 BS01 FAD D 1 G7 A8 G9 V10 I11 A36 D37 R38 T44 T45 A48 G50 L51 K163 V164 T182 W185 R283 G312 G313 Y314 G315 L316 T317 G7 A8 G9 V10 I11 A36 D37 R38 T44 T45 A48 G50 L51 K163 V164 T182 W185 R283 G312 G313 Y314 G315 L316 T317 L51 G313 T317 L51 G313 T317 1.4.3.3 0003884,0005515,0005576,0005737,0005741,0005777,0005782,0005829,0006562,0007586,0016491,0019478,0036088,0042416,0042802,0042995,0045202,0046416,0048786,0055130,0070178,0070945,0071949 P14920 19438227 352 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLS 3g3e D 2.2 BS02 G3E D 1 Y224 Y228 R283 G313 Y224 Y228 R283 G313 L51 G313 T317 L51 G313 T317 1.4.3.3 0003884,0005515,0005576,0005737,0005741,0005777,0005782,0005829,0006562,0007586,0016491,0019478,0036088,0042416,0042802,0042995,0045202,0046416,0048786,0055130,0070178,0070945,0071949 ic50=4nM IC50=4nM, Kd=13nM P14920 19438227 353 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLS