3fl9 A 2.4 BS01 CA A 1 Y108 D110 Y108 D110 M6 L21 W23 E28 L29 V32 L55 I93 T115 M6 L21 W23 E28 L29 V32 L55 I93 T115 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 Q81R22 19364848 300 MIVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAFEGDTFFPEMDNWKEVFVEKGLTDEKNPYTYYYHVYEKQQLVPR 3fl9 A 2.4 BS02 TOP A 1 M6 V7 A8 V32 I51 L55 F96 M6 V7 A8 V32 I51 L55 F96 M6 L21 W23 E28 L29 V32 L55 I93 T115 M6 L21 W23 E28 L29 V32 L55 I93 T115 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 ic50=77.2mM -logKd/Ki=1.11, IC50=77.2mM Ki=24100nM, IC50=71000nM Q81R22 19364848 200 MIVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAFEGDTFFPEMDNWKEVFVEKGLTDEKNPYTYYYHVYEKQQLVPR 3fl9 B 2.4 BS01 CA B 1 Y108 D110 Y107 D109 M6 L21 W23 E28 L29 V32 L55 I93 T115 M6 L20 W22 E27 L28 V31 L54 I92 T114 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 Q81R22 19364848 300 MIVSFMVAMDENRVIGKDNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAFEGDTFFPEMDWKEVFVEKGLTDEKNPYTYYYHVYEKQQ 3fl9 B 2.4 BS02 TOP B 1 M6 V7 A8 L21 E28 V32 A50 I51 F96 M6 V7 A8 L20 E27 V31 A49 I50 F95 M6 L21 W23 E28 L29 V32 L55 I93 T115 M6 L20 W22 E27 L28 V31 L54 I92 T114 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 ic50=77.2mM Ki=24100nM, IC50=71000nM Q81R22 19364848 200 MIVSFMVAMDENRVIGKDNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAFEGDTFFPEMDWKEVFVEKGLTDEKNPYTYYYHVYEKQQ 3fl9 C 2.4 BS01 CA C 1 Y108 D110 Y108 D110 M6 L21 W23 E28 L29 V32 L55 I93 T115 M6 L21 W23 E28 L29 V32 L55 I93 T115 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 Q81R22 19364848 300 MIVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAFEGDTFFPEMDTNWKEVFVEKGLTDEKNPYTYYYHVYEKQQLVPR 3fl9 C 2.4 BS02 TOP C 1 M6 V7 A8 E28 L29 V32 I51 F96 M6 V7 A8 E28 L29 V32 I51 F96 M6 L21 W23 E28 L29 V32 L55 I93 T115 M6 L21 W23 E28 L29 V32 L55 I93 T115 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 ic50=77.2mM Ki=24100nM, IC50=71000nM Q81R22 19364848 200 MIVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAFEGDTFFPEMDTNWKEVFVEKGLTDEKNPYTYYYHVYEKQQLVPR 3fl9 D 2.4 BS01 CA D 1 Y108 D110 Y108 D110 M6 L21 W23 E28 L29 V32 L55 I93 T115 M6 L21 W23 E28 L29 V32 L55 I93 T115 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 Q81R22 19364848 300 MIVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAFEGDTFFPEMDMNWKEVFVEKGLTDEKNPYTYYYHVYEKQQLVPR 3fl9 D 2.4 BS02 TOP D 1 M6 V7 A8 E28 V32 I51 L55 F96 M6 V7 A8 E28 V32 I51 L55 F96 M6 L21 W23 E28 L29 V32 L55 I93 T115 M6 L21 W23 E28 L29 V32 L55 I93 T115 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 ic50=77.2mM Ki=24100nM, IC50=71000nM Q81R22 19364848 200 MIVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAFEGDTFFPEMDMNWKEVFVEKGLTDEKNPYTYYYHVYEKQQLVPR 3fl9 E 2.4 BS01 TOP E 1 M6 V7 A8 L21 E28 L29 V32 I51 L55 F96 M6 V7 A8 L21 E28 L29 V32 I51 L55 F96 M6 L21 W23 E28 L29 V32 L55 I93 T115 M6 L21 W23 E28 L29 V32 L55 I93 T115 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 ic50=77.2mM Ki=24100nM, IC50=71000nM Q81R22 19364848 200 MIVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAFEGDTFFPEMDMWKEVFVEKGLTDEKNPYTYYYHVYEKQQLVPR 3fl9 F 2.4 BS01 CA F 1 Y108 D110 Y108 D110 M6 L21 W23 E28 L29 V32 L55 I93 T115 M6 L21 W23 E28 L29 V32 L55 I93 T115 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 Q81R22 19364848 300 MIVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAFEGDTFFPEMDMTWKEVFVEKGLTDEKNPYTYYYHVYEKQQLVPR 3fl9 F 2.4 BS02 TOP F 1 M6 V7 A8 L21 E28 V32 I51 F96 M6 V7 A8 L21 E28 V32 I51 F96 M6 L21 W23 E28 L29 V32 L55 I93 T115 M6 L21 W23 E28 L29 V32 L55 I93 T115 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 ic50=77.2mM Ki=24100nM, IC50=71000nM Q81R22 19364848 200 MIVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAFEGDTFFPEMDMTWKEVFVEKGLTDEKNPYTYYYHVYEKQQLVPR 3fl9 G 2.4 BS01 TOP G 1 M6 V7 A8 L21 E28 L29 V32 I51 L55 F96 M6 V7 A8 L21 E28 L29 V32 I51 L55 F96 M6 L21 W23 E28 L29 V32 L55 I93 T115 M6 L21 W23 E28 L29 V32 L55 I93 T115 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 ic50=77.2mM Ki=24100nM, IC50=71000nM Q81R22 19364848 200 MIVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAFEGDTFFPEMDNWKEVFVEKGLTDEKNPYTYYYHVYEKQQLVPR 3fl9 H 2.4 BS01 CA H 1 Y108 D110 Y108 D110 M6 L21 W23 E28 L29 V32 L55 I93 T115 M6 L21 W23 E28 L29 V32 L55 I93 T115 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 Q81R22 19364848 300 MIVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAFEGDTFFPEMDNWKEVFVEKGLTDEKNPYTYYYHVYEKQQLVPR 3fl9 H 2.4 BS02 TOP H 1 M6 V7 A8 E28 L29 V32 I51 L55 F96 M6 V7 A8 E28 L29 V32 I51 L55 F96 M6 L21 W23 E28 L29 V32 L55 I93 T115 M6 L21 W23 E28 L29 V32 L55 I93 T115 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 ic50=77.2mM Ki=24100nM, IC50=71000nM Q81R22 19364848 200 MIVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAFEGDTFFPEMDNWKEVFVEKGLTDEKNPYTYYYHVYEKQQLVPR