3faa A 3.35 BS01 55F A 1 I211 A230 K232 Y249 L278 V279 S280 Y282 H283 L340 D351 I41 A60 K62 Y79 L108 V109 S110 Y112 H113 L170 D181 D333 K335 N338 D351 T375 D163 K165 N168 D181 T203 2.7.11.30 0004672,0004675,0005524,0006468,0007178,0016020 -logKd/Ki=8.15, Ki=7.1nM Ki=7.1nM, EC50=14800nM P36897 19135364 601 ISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDINHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEG 3faa B 3.35 BS01 55F B 1 I211 A230 K232 E245 L278 V279 S280 Y282 H283 L340 D351 I41 A60 K62 E75 L108 V109 S110 Y112 H113 L166 D177 D333 K335 N338 D351 T375 D159 K161 N164 D177 T198 2.7.11.30 0004672,0004675,0005524,0006468,0007178,0016020 Ki=7.1nM, EC50=14800nM P36897 19135364 601 ISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGI 3faa C 3.35 BS01 55F C 1 I211 F216 V219 K232 Y249 L278 V279 S280 Y282 H283 L340 D351 I41 F46 V49 K62 Y79 L108 V109 S110 Y112 H113 L170 D181 D333 K335 N338 D351 T375 D163 K165 N168 D181 T205 2.7.11.30 0004672,0004675,0005524,0006468,0007178,0016020 Ki=7.1nM, EC50=14800nM P36897 19135364 601 ISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEG 3faa D 3.35 BS01 55F D 1 I211 A230 K232 L260 L278 V279 S280 Y282 H283 L340 D351 I41 A60 K62 L90 L108 V109 S110 Y112 H113 L170 D181 D333 K335 N338 D351 T375 D163 K165 N168 D181 T205 2.7.11.30 0004672,0004675,0005524,0006468,0007178,0016020 Ki=7.1nM, EC50=14800nM P36897 19135364 601 ISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEG 3faa E 3.35 BS01 55F E 1 I211 A230 K232 Y249 L260 L278 V279 S280 Y282 H283 L340 D351 I41 A60 K62 Y79 L90 L108 V109 S110 Y112 H113 L170 D181 D333 K335 N338 D351 T375 D163 K165 N168 D181 T205 2.7.11.30 0004672,0004675,0005524,0006468,0007178,0016020 Ki=7.1nM, EC50=14800nM P36897 19135364 601 ISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEG