3f88 A 2.6 BS01 3HT A 1 I62 F67 V70 A83 K85 Y134 V135 L188 C199 D200 I28 F33 V36 A49 K51 Y94 V95 L148 C159 D160 D181 K183 N186 D200 S219 D141 K143 N146 D160 S179 2.7.11.1,2.7.11.26 0004672,0005524,0006468 -logKd/Ki=8.64, IC50=2.3nM IC50=2.3nM P49841 19200745 999 SKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHAR 3f88 A 2.6 BS02 2HT A 1 G63 F67 V70 Q185 N186 D200 G29 F33 V36 Q145 N146 D160 D181 K183 N186 D200 S219 D141 K143 N146 D160 S179 2.7.11.1,2.7.11.26 0004672,0005524,0006468 P49841 19200745 998 SKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHAR 3f88 B 2.6 BS01 3HT B 1 I62 F67 A83 K85 Y134 V135 P136 R141 L188 C199 D200 I28 F33 A49 K51 Y94 V95 P96 R101 L148 C159 D160 D181 K183 N186 D200 S219 D141 K143 N146 D160 S179 2.7.11.1,2.7.11.26 0004672,0005524,0006468 IC50=2.3nM P49841 19200745 999 SKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHAR 3f88 B 2.6 BS02 2HT B 1 G63 F67 Q185 N186 G29 F33 Q145 N146 D181 K183 N186 D200 S219 D141 K143 N146 D160 S179 2.7.11.1,2.7.11.26 0004672,0005524,0006468 P49841 19200745 998 SKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHAR