3f7u A 2.0 BS01 ZN A 1 H94 H96 H119 H89 H91 H114 H64 H94 H96 E106 H119 T199 H62 H89 H91 E101 H114 T188 4.2.1.1 0004089,0005515,0005791,0005793,0005794,0005802,0005886,0006730,0008270,0009897,0009986,0015701,0016020,0016323,0016324,0016829,0030658,0030667,0031526,0046872,0048471,0070062,0098552 P22748 20363633 260 WCYEVQAESCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKS 3f7u A 2.0 BS02 AG4 A 1 H64 Q92 H94 H119 V121 L198 T199 T200 H62 Q87 H89 H114 V116 L187 T188 T189 H64 H94 H96 E106 H119 T199 H62 H89 H91 E101 H114 T188 4.2.1.1 0004089,0005515,0005791,0005793,0005794,0005802,0005886,0006730,0008270,0009897,0009986,0015701,0016020,0016323,0016324,0016829,0030658,0030667,0031526,0046872,0048471,0070062,0098552 ic50=246nM -logKd/Ki=6.61, IC50=246nM IC50=246nM P22748 20363633 265 WCYEVQAESCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKS 3f7u B 2.0 BS01 ZN B 1 H94 H96 H119 H89 H91 H114 H64 H94 H96 E106 H119 T199 H62 H89 H91 E101 H114 T188 4.2.1.1 0004089,0005515,0005791,0005793,0005794,0005802,0005886,0006730,0008270,0009897,0009986,0015701,0016020,0016323,0016324,0016829,0030658,0030667,0031526,0046872,0048471,0070062,0098552 P22748 20363633 261 WCYEVQAESCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKS 3f7u B 2.0 BS02 AG4 B 1 N62 Q92 H94 H119 V121 I141 L198 T199 T200 N60 Q87 H89 H114 V116 I126 L187 T188 T189 H64 H94 H96 E106 H119 T199 H62 H89 H91 E101 H114 T188 4.2.1.1 0004089,0005515,0005791,0005793,0005794,0005802,0005886,0006730,0008270,0009897,0009986,0015701,0016020,0016323,0016324,0016829,0030658,0030667,0031526,0046872,0048471,0070062,0098552 ic50=246nM IC50=246nM P22748 20363633 266 WCYEVQAESCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKS 3f7u C 2.0 BS01 ZN C 1 H94 H96 H119 H89 H91 H114 H64 H94 H96 E106 H119 T199 H62 H89 H91 E101 H114 T188 4.2.1.1 0004089,0005515,0005791,0005793,0005794,0005802,0005886,0006730,0008270,0009897,0009986,0015701,0016020,0016323,0016324,0016829,0030658,0030667,0031526,0046872,0048471,0070062,0098552 P22748 20363633 262 WCYEVQAESCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKS 3f7u C 2.0 BS02 AG4 C 1 N62 H64 S65 K91 Q92 H94 H96 H119 V121 L198 T199 T200 N60 H62 S63 K86 Q87 H89 H91 H114 V116 L187 T188 T189 H64 H94 H96 E106 H119 T199 H62 H89 H91 E101 H114 T188 4.2.1.1 0004089,0005515,0005791,0005793,0005794,0005802,0005886,0006730,0008270,0009897,0009986,0015701,0016020,0016323,0016324,0016829,0030658,0030667,0031526,0046872,0048471,0070062,0098552 ic50=246nM IC50=246nM P22748 20363633 267 WCYEVQAESCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKS 3f7u D 2.0 BS01 ZN D 1 H94 H96 H119 H89 H91 H114 H64 H94 H96 E106 H119 T199 H62 H89 H91 E101 H114 T188 4.2.1.1 0004089,0005515,0005791,0005793,0005794,0005802,0005886,0006730,0008270,0009897,0009986,0015701,0016020,0016323,0016324,0016829,0030658,0030667,0031526,0046872,0048471,0070062,0098552 P22748 20363633 263 WCYEVQAESCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKS 3f7u D 2.0 BS02 AG4 D 1 N62 H64 Q92 H94 H119 V121 E123 I141 L198 T199 T200 N60 H62 Q87 H89 H114 V116 E118 I126 L187 T188 T189 H64 H94 H96 E106 H119 T199 H62 H89 H91 E101 H114 T188 4.2.1.1 0004089,0005515,0005791,0005793,0005794,0005802,0005886,0006730,0008270,0009897,0009986,0015701,0016020,0016323,0016324,0016829,0030658,0030667,0031526,0046872,0048471,0070062,0098552 ic50=246nM IC50=246nM P22748 20363633 268 WCYEVQAESCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKS