3f7b A 2.05 BS01 ZN A 1 H94 H96 H119 H96 H98 H121 H64 H94 H96 E106 H119 T199 H69 H96 H98 E108 H121 T198 4.2.1.1 0004089,0005515,0005791,0005793,0005794,0005802,0005886,0006730,0008270,0009897,0009986,0015701,0016020,0016323,0016324,0016829,0030658,0030667,0031526,0046872,0048471,0070062,0098552 P22748 20363633 300 ESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKS 3f7b A 2.05 BS02 AG5 A 1 N62 H64 S65 K91 Q92 H94 H96 H119 V121 I141 L198 T199 T200 N67 H69 S70 K93 Q94 H96 H98 H121 V123 I136 L197 T198 T199 H64 H94 H96 E106 H119 T199 H69 H96 H98 E108 H121 T198 4.2.1.1 0004089,0005515,0005791,0005793,0005794,0005802,0005886,0006730,0008270,0009897,0009986,0015701,0016020,0016323,0016324,0016829,0030658,0030667,0031526,0046872,0048471,0070062,0098552 ic50=64nM -logKd/Ki=7.19, IC50=64nM IC50=64nM P22748 20363633 302 ESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKS 3f7b B 2.05 BS01 ZN B 1 H94 H96 H119 H90 H92 H115 H64 H94 H96 E106 H119 T199 H63 H90 H92 E102 H115 T188 4.2.1.1 0004089,0005515,0005791,0005793,0005794,0005802,0005886,0006730,0008270,0009897,0009986,0015701,0016020,0016323,0016324,0016829,0030658,0030667,0031526,0046872,0048471,0070062,0098552 P22748 20363633 301 WCYEVQAESPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKS 3f7b B 2.05 BS02 AG5 B 1 N62 H64 S65 Q92 H94 H96 H119 V121 L198 T199 T200 N61 H63 S64 Q88 H90 H92 H115 V117 L187 T188 T189 H64 H94 H96 E106 H119 T199 H63 H90 H92 E102 H115 T188 4.2.1.1 0004089,0005515,0005791,0005793,0005794,0005802,0005886,0006730,0008270,0009897,0009986,0015701,0016020,0016323,0016324,0016829,0030658,0030667,0031526,0046872,0048471,0070062,0098552 ic50=64nM IC50=64nM P22748 20363633 303 WCYEVQAESPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKS