3f0r A 2.54 BS01 ZN A 1 D178 H180 D267 D164 H166 D253 3.5.1.-,3.5.1.98 0000118,0000122,0000228,0004407,0005515,0005634,0005654,0005694,0005737,0006325,0007064,0016787,0030544,0031397,0031647,0032204,0033558,0040029,0046872,0051879,0140297,0160008,0160009 Q9BY41 19053282 400 SLVPVYIYSPEYVSMCDSLIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVVI 3f0r A 2.54 BS02 TSN A 1 I34 P35 R37 W141 P273 Y306 I20 P21 R23 W127 P259 Y292 3.5.1.-,3.5.1.98 0000118,0000122,0000228,0004407,0005515,0005634,0005654,0005694,0005737,0006325,0007064,0016787,0030544,0031397,0031647,0032204,0033558,0040029,0046872,0051879,0140297,0160008,0160009 -logKd/Ki=6.89, Ki=130nM IC50=90nM, Ki=45nM, Kd=3.9e+2nM Q9BY41 19053282 800 SLVPVYIYSPEYVSMCDSLIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVVI 3f0r A 2.54 BS03 TSN A 2 Y100 H143 F152 D178 H180 Y306 Y86 H129 F138 D164 H166 Y292 3.5.1.-,3.5.1.98 0000118,0000122,0000228,0004407,0005515,0005634,0005654,0005694,0005737,0006325,0007064,0016787,0030544,0031397,0031647,0032204,0033558,0040029,0046872,0051879,0140297,0160008,0160009 -logKd/Ki=6.89, Ki=130nM IC50=90nM, Ki=45nM, Kd=3.9e+2nM Q9BY41 19053282 801 SLVPVYIYSPEYVSMCDSLIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVVI 3f0r B 2.54 BS01 ZN B 1 D178 H180 D267 D166 H168 D255 3.5.1.-,3.5.1.98 0000118,0000122,0000228,0004407,0005515,0005634,0005654,0005694,0005737,0006325,0007064,0016787,0030544,0031397,0031647,0032204,0033558,0040029,0046872,0051879,0140297,0160008,0160009 Q9BY41 19053282 403 SLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVVI 3f0r B 2.54 BS02 TSN B 1 Y100 H143 F152 D178 H180 M274 Y306 Y88 H131 F140 D166 H168 M262 Y294 3.5.1.-,3.5.1.98 0000118,0000122,0000228,0004407,0005515,0005634,0005654,0005694,0005737,0006325,0007064,0016787,0030544,0031397,0031647,0032204,0033558,0040029,0046872,0051879,0140297,0160008,0160009 IC50=90nM, Ki=45nM, Kd=3.9e+2nM Q9BY41 19053282 804 SLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVVI 3f0r B 2.54 BS03 TSN B 2 P35 Y111 W141 P273 Y306 P23 Y99 W129 P261 Y294 3.5.1.-,3.5.1.98 0000118,0000122,0000228,0004407,0005515,0005634,0005654,0005694,0005737,0006325,0007064,0016787,0030544,0031397,0031647,0032204,0033558,0040029,0046872,0051879,0140297,0160008,0160009 IC50=90nM, Ki=45nM, Kd=3.9e+2nM Q9BY41 19053282 805 SLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVVI 3f0r C 2.54 BS01 ZN C 1 D178 H180 D267 D156 H158 D245 3.5.1.-,3.5.1.98 0000118,0000122,0000228,0004407,0005515,0005634,0005654,0005694,0005737,0006325,0007064,0016787,0030544,0031397,0031647,0032204,0033558,0040029,0046872,0051879,0140297,0160008,0160009 Q9BY41 19053282 406 SLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV 3f0r C 2.54 BS02 TSN C 1 K33 Y100 H143 F152 D178 H180 Y306 K21 Y78 H121 F130 D156 H158 Y284 3.5.1.-,3.5.1.98 0000118,0000122,0000228,0004407,0005515,0005634,0005654,0005694,0005737,0006325,0007064,0016787,0030544,0031397,0031647,0032204,0033558,0040029,0046872,0051879,0140297,0160008,0160009 IC50=90nM, Ki=45nM, Kd=3.9e+2nM Q9BY41 19053282 802 SLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV 3f0r C 2.54 BS03 TSN C 2 P35 R37 W141 F152 P273 M274 Y306 P23 R25 W119 F130 P251 M252 Y284 3.5.1.-,3.5.1.98 0000118,0000122,0000228,0004407,0005515,0005634,0005654,0005694,0005737,0006325,0007064,0016787,0030544,0031397,0031647,0032204,0033558,0040029,0046872,0051879,0140297,0160008,0160009 IC50=90nM, Ki=45nM, Kd=3.9e+2nM Q9BY41 19053282 803 SLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV