3ey4 A 3.0 BS01 NDP A 1 G41 S43 K44 G45 I46 A65 R66 T92 M93 N119 I121 V168 S170 Y183 K187 L215 G216 I218 T220 T222 A223 G17 S19 K20 G21 I22 A41 R42 T68 M69 N95 I97 V144 S146 Y159 K163 L191 G192 I194 T196 T198 A199 S170 Y183 K187 S146 Y159 K163 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 P28845 501 EEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYSTS 3ey4 A 3.0 BS02 352 A 1 T124 S125 S170 L171 A172 Y177 Y183 T100 S101 S146 L147 A148 Y153 Y159 S170 Y183 K187 S146 Y159 K163 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 Ki=35nM, IC50=34nM P28845 601 EEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYSTS 3ey4 B 3.0 BS01 NDP B 1 G41 S43 K44 G45 A65 R66 S67 M93 N119 I121 N123 S170 Y183 K187 L215 G216 L217 I218 T220 T222 G15 S17 K18 G19 A39 R40 S41 M67 N93 I95 N97 S144 Y157 K161 L189 G190 L191 I192 T194 T196 S170 Y183 K187 S144 Y157 K161 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 P28845 502 FRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYS 3ey4 B 3.0 BS02 352 B 1 S125 L126 S170 L171 A172 Y183 G216 S99 L100 S144 L145 A146 Y157 G190 S170 Y183 K187 S144 Y157 K161 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 Ki=35nM, IC50=34nM P28845 603 FRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYS 3ey4 C 3.0 BS01 NDP C 1 G41 S43 K44 G45 I46 A65 R66 S67 M93 N119 I121 V168 S170 Y183 K187 L215 L217 I218 T220 T222 G16 S18 K19 G20 I21 A40 R41 S42 M68 N94 I96 V143 S145 Y158 K162 L190 L192 I193 T195 T197 S170 Y183 K187 S145 Y158 K162 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 P28845 503 EFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYS 3ey4 C 3.0 BS02 352 C 1 S125 L126 L171 A172 Y177 Y183 M233 S100 L101 L146 A147 Y152 Y158 M208 S170 Y183 K187 S145 Y158 K162 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 Ki=35nM, IC50=34nM P28845 602 EFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYS 3ey4 D 3.0 BS01 NDP D 1 G41 S43 K44 G45 I46 R66 S67 M93 N119 I121 V168 S170 Y183 K187 L215 G216 L217 I218 T220 T222 G17 S19 K20 G21 I22 R42 S43 M69 N95 I97 V144 S146 Y159 K163 L191 G192 L193 I194 T196 T198 S170 Y183 K187 S146 Y159 K163 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 P28845 504 EEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYSTSYN 3ey4 D 3.0 BS02 352 D 1 T124 S125 L126 S170 L171 A172 Y177 V180 Y183 T100 S101 L102 S146 L147 A148 Y153 V156 Y159 S170 Y183 K187 S146 Y159 K163 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 Ki=35nM, IC50=34nM P28845 604 EEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYSTSYN