3exh A 2.444 BS01 MN A 1 D167 N196 Y198 G199 D168 N197 Y199 G200 Q51 G136 R259 H263 S264 Y272 Q52 G137 R257 H261 S262 Y270 1.2.4.1 0004738,0004739,0005515,0005634,0005730,0005739,0005759,0006006,0006086,0006090,0006099,0016491,0016624,0034604,0043231,0045254,0046872,1902494 P08559 19081061 1500 MFANDATFEIKKCDLHRLEEGPPVTTVLTREDGLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRAHGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGERAAASTDYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVAYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPPLEELGYHIYSSDPPFEVRGANQWIKFKSVS 3exh A 2.444 BS02 TPP A 1 Y89 R90 V138 G166 D167 G168 N196 Y198 G199 R259 Y90 R91 V139 G167 D168 G169 N197 Y199 G200 R257 Q51 G136 R259 H263 S264 Y272 Q52 G137 R257 H261 S262 Y270 1.2.4.1 0004738,0004739,0005515,0005634,0005730,0005739,0005759,0006006,0006086,0006090,0006099,0016491,0016624,0034604,0043231,0045254,0046872,1902494 -logKd/Ki=4.88, Kd=13.1uM P08559 19081061 1502 MFANDATFEIKKCDLHRLEEGPPVTTVLTREDGLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRAHGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGERAAASTDYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVAYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPPLEELGYHIYSSDPPFEVRGANQWIKFKSVS 3exh B 2.444 BS01 TPP C 1 I57 E59 F85 Q88 I57 E59 F85 Q88 E59 H128 E59 H128 1.2.4.1 0003824,0004739,0005515,0005634,0005654,0005739,0005759,0006006,0006086,0006099,0016491,0034604,0045254,0046872 -logKd/Ki=4.88, Kd=13.1uM P11177 19081061 1502 LQVTVRDAINQGMDEELERDEKVFLLGEEVAQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAIDQVINSAAKTYYMSGGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNSEDAKGLIKSAIRDNNPVVVLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITVVSHSRPVGHCLEAAAVLSKEGVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWPQFGVGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI 3exh C 2.444 BS01 MN C 1 D167 N196 Y198 G199 D168 N197 Y199 G200 Q51 G136 R259 H263 S264 Y272 Q52 G137 R260 H264 S265 Y273 1.2.4.1 0004738,0004739,0005515,0005634,0005730,0005739,0005759,0006006,0006086,0006090,0006099,0016491,0016624,0034604,0043231,0045254,0046872,1902494 P08559 19081061 1500 MFANDATFEIKKCDLHRLEEGPPVTTVLTREDGLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRAHGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTAVERAAASTDYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVAYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPPLEELGYHIYSSDPPFEVRGANQWIKFKSVS 3exh C 2.444 BS02 TPP C 1 Y89 R90 V138 G166 D167 G168 A169 N196 Y198 G199 M200 H263 Y90 R91 V139 G167 D168 G169 A170 N197 Y199 G200 M201 H264 Q51 G136 R259 H263 S264 Y272 Q52 G137 R260 H264 S265 Y273 1.2.4.1 0004738,0004739,0005515,0005634,0005730,0005739,0005759,0006006,0006086,0006090,0006099,0016491,0016624,0034604,0043231,0045254,0046872,1902494 P08559 19081061 1502 MFANDATFEIKKCDLHRLEEGPPVTTVLTREDGLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRAHGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTAVERAAASTDYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVAYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPPLEELGYHIYSSDPPFEVRGANQWIKFKSVS 3exh D 2.444 BS01 TPP A 1 E28 I57 E59 F85 Q88 E28 I57 E59 F85 Q88 E59 H128 E59 H128 1.2.4.1 0003824,0004739,0005515,0005634,0005654,0005739,0005759,0006006,0006086,0006099,0016491,0034604,0045254,0046872 -logKd/Ki=4.88, Kd=13.1uM P11177 19081061 1502 LQVTVRDAINQGMDEELERDEKVFLLGEEVAQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAIDQVINSAAKTYYMSGGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNSEDAKGLIKSAIRDNNPVVVLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITVVSHSRPVGHCLEAAAVLSKEGVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWPQFGVGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI 3exh E 2.444 BS01 MN E 1 D167 N196 D168 N197 Q51 G136 Q52 G137 1.2.4.1 0004738,0004739,0005515,0005634,0005730,0005739,0005759,0006006,0006086,0006090,0006099,0016491,0016624,0034604,0043231,0045254,0046872,1902494 P08559 19081061 1500 MFANDATFEIKKCDLHRLEEGPPVTTVLTREDGLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRAHGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRERAAASTDYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPPLEELGYHIYSSDPPFEVRGANQWIKFKSVS 3exh E 2.444 BS02 TPP E 1 Y89 R90 V138 G166 D167 G168 N196 Y90 R91 V139 G167 D168 G169 N197 Q51 G136 Q52 G137 1.2.4.1 0004738,0004739,0005515,0005634,0005730,0005739,0005759,0006006,0006086,0006090,0006099,0016491,0016624,0034604,0043231,0045254,0046872,1902494 P08559 19081061 1502 MFANDATFEIKKCDLHRLEEGPPVTTVLTREDGLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRAHGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRERAAASTDYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPPLEELGYHIYSSDPPFEVRGANQWIKFKSVS 3exh F 2.444 BS01 TPP G 1 E28 I57 E59 F85 Q88 E28 I57 E59 F85 Q88 E59 H128 E59 H128 1.2.4.1 0003824,0004739,0005515,0005634,0005654,0005739,0005759,0006006,0006086,0006099,0016491,0034604,0045254,0046872 P11177 19081061 1502 LQVTVRDAINQGMDEELERDEKVFLLGEEVAQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAIDQVINSAAKTYYMSGGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNSEDAKGLIKSAIRDNNPVVVLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITVVSHSRPVGHCLEAAAVLSKEGVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWPQFGVGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI 3exh G 2.444 BS01 MN G 1 D167 N196 Y198 G199 D168 N197 Y199 G200 Q51 G136 R259 H263 S264 Y272 Q52 G137 R260 H264 S265 Y273 1.2.4.1 0004738,0004739,0005515,0005634,0005730,0005739,0005759,0006006,0006086,0006090,0006099,0016491,0016624,0034604,0043231,0045254,0046872,1902494 P08559 19081061 1500 MFANDATFEIKKCDLHRLEEGPPVTTVLTREDGLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRAHGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTAVERAAASTDYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVAYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPPLEELGYHIYSSDPPFEVRGANQWIKFKSVS 3exh G 2.444 BS02 TPP G 1 Y89 R90 V138 G166 D167 G168 A169 N196 Y198 G199 M200 H263 Y90 R91 V139 G167 D168 G169 A170 N197 Y199 G200 M201 H264 Q51 G136 R259 H263 S264 Y272 Q52 G137 R260 H264 S265 Y273 1.2.4.1 0004738,0004739,0005515,0005634,0005730,0005739,0005759,0006006,0006086,0006090,0006099,0016491,0016624,0034604,0043231,0045254,0046872,1902494 P08559 19081061 1502 MFANDATFEIKKCDLHRLEEGPPVTTVLTREDGLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRAHGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTAVERAAASTDYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVAYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPPLEELGYHIYSSDPPFEVRGANQWIKFKSVS 3exh H 2.444 BS01 TPP E 1 I57 E59 F85 Q88 I57 E59 F85 Q88 E59 H128 E59 H128 1.2.4.1 0003824,0004739,0005515,0005634,0005654,0005739,0005759,0006006,0006086,0006099,0016491,0034604,0045254,0046872 P11177 19081061 1502 LQVTVRDAINQGMDEELERDEKVFLLGEEVAQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAIDQVINSAAKTYYMSGGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNSEDAKGLIKSAIRDNNPVVVLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITVVSHSRPVGHCLEAAAVLSKEGVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWPQFGVGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI