3exf A 2.998 BS01 MG A 1 D167 N196 Y198 D168 N197 Y199 Q51 G136 R259 H263 S264 Y272 Q52 G137 R260 H264 S265 Y273 1.2.4.1 0004738,0004739,0005515,0005634,0005730,0005739,0005759,0006006,0006086,0006090,0006099,0016491,0016624,0034604,0043231,0045254,0046872,1902494 P08559 19081061 1001 MFANDATFEIKKCDLHRLEEGPPVTTVLTREDGLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRAHGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTAVERAAASTDYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVAYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPPLEELGYHIYSSDPPFEVRGANQWIKFKSVS 3exf A 2.998 BS02 TPP A 1 Y89 R90 V138 G166 D167 G168 A169 N196 Y198 G199 M200 H263 Y90 R91 V139 G167 D168 G169 A170 N197 Y199 G200 M201 H264 Q51 G136 R259 H263 S264 Y272 Q52 G137 R260 H264 S265 Y273 1.2.4.1 0004738,0004739,0005515,0005634,0005730,0005739,0005759,0006006,0006086,0006090,0006099,0016491,0016624,0034604,0043231,0045254,0046872,1902494 -logKd/Ki=6.54, Kd=0.29uM P08559 19081061 1003 MFANDATFEIKKCDLHRLEEGPPVTTVLTREDGLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRAHGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTAVERAAASTDYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVAYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPPLEELGYHIYSSDPPFEVRGANQWIKFKSVS 3exf B 2.998 BS01 TPP C 1 E28 I57 E59 F85 Q88 E28 I57 E59 F85 Q88 E59 H128 E59 H128 1.2.4.1 0003824,0004739,0005515,0005634,0005654,0005739,0005759,0006006,0006086,0006099,0016491,0034604,0045254,0046872 -logKd/Ki=6.54, Kd=0.29uM P11177 19081061 1006 LQVTVRDAINQGMDEELERDEKVFLLGEEVAQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAIDQVINSAAKTYYMSGGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNSEDAKGLIKSAIRDNNPVVVLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITVVSHSRPVGHCLEAAAVLSKEGVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWPQFGVGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI 3exf C 2.998 BS01 MG C 1 D167 N196 Y198 D169 N198 Y200 Q51 G136 R259 H263 S264 Y272 Q53 G138 R261 H265 S266 Y274 1.2.4.1 0004738,0004739,0005515,0005634,0005730,0005739,0005759,0006006,0006086,0006090,0006099,0016491,0016624,0034604,0043231,0045254,0046872,1902494 P08559 19081061 1004 HMFANDATFEIKKCDLHRLEEGPPVTTVLTREDGLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRAHGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTAVERAAASTDYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVAYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPPLEELGYHIYSSDPPFEVRGANQWIKFKSVS 3exf C 2.998 BS02 TPP C 1 Y89 R90 V138 G166 D167 G168 Y198 G199 M200 Y91 R92 V140 G168 D169 G170 Y200 G201 M202 Q51 G136 R259 H263 S264 Y272 Q53 G138 R261 H265 S266 Y274 1.2.4.1 0004738,0004739,0005515,0005634,0005730,0005739,0005759,0006006,0006086,0006090,0006099,0016491,0016624,0034604,0043231,0045254,0046872,1902494 P08559 19081061 1006 HMFANDATFEIKKCDLHRLEEGPPVTTVLTREDGLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRAHGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTAVERAAASTDYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVAYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPPLEELGYHIYSSDPPFEVRGANQWIKFKSVS 3exf D 2.998 BS01 TPP A 1 E28 I57 E59 F85 Q88 E28 I57 E59 F85 Q88 E59 H128 E59 H128 1.2.4.1 0003824,0004739,0005515,0005634,0005654,0005739,0005759,0006006,0006086,0006099,0016491,0034604,0045254,0046872 -logKd/Ki=6.54, Kd=0.29uM P11177 19081061 1003 LQVTVRDAINQGMDEELERDEKVFLLGEEVAQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAIDQVINSAAKTYYMSGGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNSEDAKGLIKSAIRDNNPVVVLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITVVSHSRPVGHCLEAAAVLSKEGVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWPQFGVGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI 3exf E 2.998 BS01 MG E 1 D167 N196 Y198 D169 N198 Y200 Q51 G136 R259 H263 S264 Y272 Q53 G138 R261 H265 S266 Y274 1.2.4.1 0004738,0004739,0005515,0005634,0005730,0005739,0005759,0006006,0006086,0006090,0006099,0016491,0016624,0034604,0043231,0045254,0046872,1902494 P08559 19081061 1007 HMFANDATFEIKKCDLHRLEEGPPVTTVLTREDGLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRAHGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTAVERAAASTDYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVAYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPPLEELGYHIYSSDPPFEVRGANQWIKFKSVS 3exf E 2.998 BS02 TPP E 1 Y89 R90 V138 G166 D167 G168 A169 N196 Y198 G199 M200 H263 Y91 R92 V140 G168 D169 G170 A171 N198 Y200 G201 M202 H265 Q51 G136 R259 H263 S264 Y272 Q53 G138 R261 H265 S266 Y274 1.2.4.1 0004738,0004739,0005515,0005634,0005730,0005739,0005759,0006006,0006086,0006090,0006099,0016491,0016624,0034604,0043231,0045254,0046872,1902494 P08559 19081061 1009 HMFANDATFEIKKCDLHRLEEGPPVTTVLTREDGLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRAHGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTAVERAAASTDYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVAYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPPLEELGYHIYSSDPPFEVRGANQWIKFKSVS 3exf F 2.998 BS01 TPP G 1 I57 E59 F85 Q88 I57 E59 F85 Q88 E59 H128 E59 H128 1.2.4.1 0003824,0004739,0005515,0005634,0005654,0005739,0005759,0006006,0006086,0006099,0016491,0034604,0045254,0046872 P11177 19081061 1012 LQVTVRDAINQGMDEELERDEKVFLLGEEVAQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAIDQVINSAAKTYYMSGGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNSEDAKGLIKSAIRDNNPVVVLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITVVSHSRPVGHCLEAAAVLSKEGVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWPQFGVGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI 3exf G 2.998 BS01 MG G 1 D167 N196 Y198 D168 N197 Y199 Q51 G136 R259 H263 S264 Y272 Q52 G137 R260 H264 S265 Y273 1.2.4.1 0004738,0004739,0005515,0005634,0005730,0005739,0005759,0006006,0006086,0006090,0006099,0016491,0016624,0034604,0043231,0045254,0046872,1902494 P08559 19081061 1010 MFANDATFEIKKCDLHRLEEGPPVTTVLTREDGLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRAHGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTAVERAAASTDYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVAYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPPLEELGYHIYSSDPPFEVRGANQWIKFKSVS 3exf G 2.998 BS02 TPP G 1 Y89 R90 I137 V138 G166 D167 G168 A169 N196 Y198 G199 M200 H263 Y90 R91 I138 V139 G167 D168 G169 A170 N197 Y199 G200 M201 H264 Q51 G136 R259 H263 S264 Y272 Q52 G137 R260 H264 S265 Y273 1.2.4.1 0004738,0004739,0005515,0005634,0005730,0005739,0005759,0006006,0006086,0006090,0006099,0016491,0016624,0034604,0043231,0045254,0046872,1902494 P08559 19081061 1012 MFANDATFEIKKCDLHRLEEGPPVTTVLTREDGLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRAHGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTAVERAAASTDYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVAYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPPLEELGYHIYSSDPPFEVRGANQWIKFKSVS 3exf H 2.998 BS01 TPP E 1 E28 I57 E59 F85 Q88 E28 I57 E59 F85 Q88 E59 H128 E59 H128 1.2.4.1 0003824,0004739,0005515,0005634,0005654,0005739,0005759,0006006,0006086,0006099,0016491,0034604,0045254,0046872 P11177 19081061 1009 LQVTVRDAINQGMDEELERDEKVFLLGEEVAQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAIDQVINSAAKTYYMSGGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNSEDAKGLIKSAIRDNNPVVVLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITVVSHSRPVGHCLEAAAVLSKEGVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWPQFGVGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI