3euf A 1.9 BS01 BAU A 1 T141 S142 G143 F213 Q217 R219 I247 E248 I281 T126 S127 G128 F198 Q202 R204 I232 E233 I266 E121 R275 E106 R260 2.4.2.3 0003824,0004850,0005654,0005737,0005829,0006139,0006218,0006220,0006248,0006249,0009032,0009116,0009164,0009166,0016757,0016763,0042149,0042802,0044206,0046050,0046074,0046079,0046108,0047847 Kd=1200nM Q16831 19291308 400 DCPVRLLNPNIAKMKEDILYHFNLTTSRHNFPALFGDVKFVCVGGSPSRMKAFIRCVGAELGLDCPGRDYPNICAGTDRYAMYKVGPVLSVSHGMGIPSISIMLHELIKLLYYARCSNVTIIRIGTSGGIGLEPGTVVITEQAVDTCFKAEFEQIVLGKRVIRKTDLNKKLVQELLLCSAELSEFTTVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQAYLEAAYAAGVRNIEMESSVFAAMCSACGLQAAVVCVTLLNRLEGDQISSPRNVLSEYQQRPQRLVSYFIKKKLS 3euf A 1.9 BS02 PO4 A 1 G60 R138 G140 T141 G45 R123 G125 T126 E121 R275 E106 R260 2.4.2.3 0003824,0004850,0005654,0005737,0005829,0006139,0006218,0006220,0006248,0006249,0009032,0009116,0009164,0009166,0016757,0016763,0042149,0042802,0044206,0046050,0046074,0046079,0046108,0047847 Q16831 19291308 401 DCPVRLLNPNIAKMKEDILYHFNLTTSRHNFPALFGDVKFVCVGGSPSRMKAFIRCVGAELGLDCPGRDYPNICAGTDRYAMYKVGPVLSVSHGMGIPSISIMLHELIKLLYYARCSNVTIIRIGTSGGIGLEPGTVVITEQAVDTCFKAEFEQIVLGKRVIRKTDLNKKLVQELLLCSAELSEFTTVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQAYLEAAYAAGVRNIEMESSVFAAMCSACGLQAAVVCVTLLNRLEGDQISSPRNVLSEYQQRPQRLVSYFIKKKLS 3euf A 1.9 BS03 BAU B 1 Y35 H36 Y20 H21 E121 R275 E106 R260 2.4.2.3 0003824,0004850,0005654,0005737,0005829,0006139,0006218,0006220,0006248,0006249,0009032,0009116,0009164,0009166,0016757,0016763,0042149,0042802,0044206,0046050,0046074,0046079,0046108,0047847 Kd=1200nM Q16831 19291308 400 DCPVRLLNPNIAKMKEDILYHFNLTTSRHNFPALFGDVKFVCVGGSPSRMKAFIRCVGAELGLDCPGRDYPNICAGTDRYAMYKVGPVLSVSHGMGIPSISIMLHELIKLLYYARCSNVTIIRIGTSGGIGLEPGTVVITEQAVDTCFKAEFEQIVLGKRVIRKTDLNKKLVQELLLCSAELSEFTTVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQAYLEAAYAAGVRNIEMESSVFAAMCSACGLQAAVVCVTLLNRLEGDQISSPRNVLSEYQQRPQRLVSYFIKKKLS 3euf B 1.9 BS01 BAU A 1 Y35 H36 Y20 H21 E121 R275 E106 R260 2.4.2.3 0003824,0004850,0005654,0005737,0005829,0006139,0006218,0006220,0006248,0006249,0009032,0009116,0009164,0009166,0016757,0016763,0042149,0042802,0044206,0046050,0046074,0046079,0046108,0047847 Kd=1200nM Q16831 19291308 400 DCPVRLLNPNIAKMKEDILYHFNLTTSRHNFPALFGDVKFVCVGGSPSRMKAFIRCVGAELGLDCPGRDYPNICAGTDRYAMYKVGPVLSVSHGMGIPSISIMLHELIKLLYYARCSNVTIIRIGTSGGIGLEPGTVVITEQAVDTCFKAEFEQIVLGKRVIRKTDLNKKLVQELLLCSAELSEFTTVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQAYLEAAYAAGVRNIEMESSVFAAMCSACGLQAAVVCVTLLNRLEGDQISSPRNVLSEYQQRPQRLVSYFIKKKLS 3euf B 1.9 BS02 BAU B 1 T141 S142 G143 F213 Q217 R219 I281 T126 S127 G128 F198 Q202 R204 I266 E121 R275 E106 R260 2.4.2.3 0003824,0004850,0005654,0005737,0005829,0006139,0006218,0006220,0006248,0006249,0009032,0009116,0009164,0009166,0016757,0016763,0042149,0042802,0044206,0046050,0046074,0046079,0046108,0047847 Kd=1200nM Q16831 19291308 400 DCPVRLLNPNIAKMKEDILYHFNLTTSRHNFPALFGDVKFVCVGGSPSRMKAFIRCVGAELGLDCPGRDYPNICAGTDRYAMYKVGPVLSVSHGMGIPSISIMLHELIKLLYYARCSNVTIIRIGTSGGIGLEPGTVVITEQAVDTCFKAEFEQIVLGKRVIRKTDLNKKLVQELLLCSAELSEFTTVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQAYLEAAYAAGVRNIEMESSVFAAMCSACGLQAAVVCVTLLNRLEGDQISSPRNVLSEYQQRPQRLVSYFIKKKLS 3euf B 1.9 BS03 PO4 B 1 G60 R138 G140 T141 G45 R123 G125 T126 E121 R275 E106 R260 2.4.2.3 0003824,0004850,0005654,0005737,0005829,0006139,0006218,0006220,0006248,0006249,0009032,0009116,0009164,0009166,0016757,0016763,0042149,0042802,0044206,0046050,0046074,0046079,0046108,0047847 Q16831 19291308 401 DCPVRLLNPNIAKMKEDILYHFNLTTSRHNFPALFGDVKFVCVGGSPSRMKAFIRCVGAELGLDCPGRDYPNICAGTDRYAMYKVGPVLSVSHGMGIPSISIMLHELIKLLYYARCSNVTIIRIGTSGGIGLEPGTVVITEQAVDTCFKAEFEQIVLGKRVIRKTDLNKKLVQELLLCSAELSEFTTVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQAYLEAAYAAGVRNIEMESSVFAAMCSACGLQAAVVCVTLLNRLEGDQISSPRNVLSEYQQRPQRLVSYFIKKKLS 3euf C 1.9 BS01 BAU C 1 T141 S142 G143 F213 Q217 R219 I281 T126 S127 G128 F198 Q202 R204 I266 E121 R275 E106 R260 2.4.2.3 0003824,0004850,0005654,0005737,0005829,0006139,0006218,0006220,0006248,0006249,0009032,0009116,0009164,0009166,0016757,0016763,0042149,0042802,0044206,0046050,0046074,0046079,0046108,0047847 Kd=1200nM Q16831 19291308 400 DCPVRLLNPNIAKMKEDILYHFNLTTSRHNFPALFGDVKFVCVGGSPSRMKAFIRCVGAELGLDCPGRDYPNICAGTDRYAMYKVGPVLSVSHGMGIPSISIMLHELIKLLYYARCSNVTIIRIGTSGGIGLEPGTVVITEQAVDTCFKAEFEQIVLGKRVIRKTDLNKKLVQELLLCSAELSEFTTVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQAYLEAAYAAGVRNIEMESSVFAAMCSACGLQAAVVCVTLLNRLEGDQISSPRNVLSEYQQRPQRLVSYFIKKKLSK 3euf C 1.9 BS02 PO4 C 1 G60 R138 G140 T141 G45 R123 G125 T126 E121 R275 E106 R260 2.4.2.3 0003824,0004850,0005654,0005737,0005829,0006139,0006218,0006220,0006248,0006249,0009032,0009116,0009164,0009166,0016757,0016763,0042149,0042802,0044206,0046050,0046074,0046079,0046108,0047847 Q16831 19291308 401 DCPVRLLNPNIAKMKEDILYHFNLTTSRHNFPALFGDVKFVCVGGSPSRMKAFIRCVGAELGLDCPGRDYPNICAGTDRYAMYKVGPVLSVSHGMGIPSISIMLHELIKLLYYARCSNVTIIRIGTSGGIGLEPGTVVITEQAVDTCFKAEFEQIVLGKRVIRKTDLNKKLVQELLLCSAELSEFTTVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQAYLEAAYAAGVRNIEMESSVFAAMCSACGLQAAVVCVTLLNRLEGDQISSPRNVLSEYQQRPQRLVSYFIKKKLSK 3euf C 1.9 BS03 BAU D 1 Y35 H36 Y20 H21 E121 R275 E106 R260 2.4.2.3 0003824,0004850,0005654,0005737,0005829,0006139,0006218,0006220,0006248,0006249,0009032,0009116,0009164,0009166,0016757,0016763,0042149,0042802,0044206,0046050,0046074,0046079,0046108,0047847 Kd=1200nM Q16831 19291308 400 DCPVRLLNPNIAKMKEDILYHFNLTTSRHNFPALFGDVKFVCVGGSPSRMKAFIRCVGAELGLDCPGRDYPNICAGTDRYAMYKVGPVLSVSHGMGIPSISIMLHELIKLLYYARCSNVTIIRIGTSGGIGLEPGTVVITEQAVDTCFKAEFEQIVLGKRVIRKTDLNKKLVQELLLCSAELSEFTTVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQAYLEAAYAAGVRNIEMESSVFAAMCSACGLQAAVVCVTLLNRLEGDQISSPRNVLSEYQQRPQRLVSYFIKKKLSK 3euf D 1.9 BS01 BAU C 1 Y35 H36 Y20 H21 E121 R275 E106 R260 2.4.2.3 0003824,0004850,0005654,0005737,0005829,0006139,0006218,0006220,0006248,0006249,0009032,0009116,0009164,0009166,0016757,0016763,0042149,0042802,0044206,0046050,0046074,0046079,0046108,0047847 Kd=1200nM Q16831 19291308 400 DCPVRLLNPNIAKMKEDILYHFNLTTSRHNFPALFGDVKFVCVGGSPSRMKAFIRCVGAELGLDCPGRDYPNICAGTDRYAMYKVGPVLSVSHGMGIPSISIMLHELIKLLYYARCSNVTIIRIGTSGGIGLEPGTVVITEQAVDTCFKAEFEQIVLGKRVIRKTDLNKKLVQELLLCSAELSEFTTVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQAYLEAAYAAGVRNIEMESSVFAAMCSACGLQAAVVCVTLLNRLEGDQISSPRNVLSEYQQRPQRLVSYFIKKKLSK 3euf D 1.9 BS02 BAU D 1 T141 S142 G143 F213 Q217 R219 I247 E248 I281 T126 S127 G128 F198 Q202 R204 I232 E233 I266 E121 R275 E106 R260 2.4.2.3 0003824,0004850,0005654,0005737,0005829,0006139,0006218,0006220,0006248,0006249,0009032,0009116,0009164,0009166,0016757,0016763,0042149,0042802,0044206,0046050,0046074,0046079,0046108,0047847 Kd=1200nM Q16831 19291308 400 DCPVRLLNPNIAKMKEDILYHFNLTTSRHNFPALFGDVKFVCVGGSPSRMKAFIRCVGAELGLDCPGRDYPNICAGTDRYAMYKVGPVLSVSHGMGIPSISIMLHELIKLLYYARCSNVTIIRIGTSGGIGLEPGTVVITEQAVDTCFKAEFEQIVLGKRVIRKTDLNKKLVQELLLCSAELSEFTTVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQAYLEAAYAAGVRNIEMESSVFAAMCSACGLQAAVVCVTLLNRLEGDQISSPRNVLSEYQQRPQRLVSYFIKKKLSK 3euf D 1.9 BS03 PO4 D 1 G60 R138 G140 T141 G45 R123 G125 T126 E121 R275 E106 R260 2.4.2.3 0003824,0004850,0005654,0005737,0005829,0006139,0006218,0006220,0006248,0006249,0009032,0009116,0009164,0009166,0016757,0016763,0042149,0042802,0044206,0046050,0046074,0046079,0046108,0047847 Q16831 19291308 401 DCPVRLLNPNIAKMKEDILYHFNLTTSRHNFPALFGDVKFVCVGGSPSRMKAFIRCVGAELGLDCPGRDYPNICAGTDRYAMYKVGPVLSVSHGMGIPSISIMLHELIKLLYYARCSNVTIIRIGTSGGIGLEPGTVVITEQAVDTCFKAEFEQIVLGKRVIRKTDLNKKLVQELLLCSAELSEFTTVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQAYLEAAYAAGVRNIEMESSVFAAMCSACGLQAAVVCVTLLNRLEGDQISSPRNVLSEYQQRPQRLVSYFIKKKLSK