3efk A 2.2 BS01 MT4 A 1 I1084 F1089 A1108 F1124 E1127 G1128 M1131 L1140 L1142 L1157 Y1159 M1160 G1163 M1211 D1222 F1223 I31 F36 A55 F71 E74 G75 M78 L87 L89 L104 Y106 M107 G110 M158 D169 F170 D1204 A1206 R1208 N1209 D1222 D151 A153 R155 N156 D169 2.7.10.1 0004672,0004713,0005524,0006468 Ki=14nM -logKd/Ki=7.85, Ki=14nM Ki=14nM, IC50=14nM P08581 18763753 1 DLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVH 3efk B 2.2 BS01 MT4 B 1 I1084 F1089 A1108 F1124 E1127 G1128 M1131 L1140 L1142 L1157 Y1159 M1160 G1163 M1211 A1221 D1222 F1223 I31 F36 A55 F67 E70 G71 M74 L83 L85 L100 Y102 M103 G106 M154 A164 D165 F166 D1204 A1206 R1208 N1209 D1222 D147 A149 R151 N152 D165 2.7.10.1 0004672,0004713,0005524,0006468 Ki=14nM -logKd/Ki=7.85, Ki=14nM Ki=14nM, IC50=14nM P08581 18763753 2 DLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVH