3e7o A 2.14 BS01 35F A 1 I32 V40 A53 M108 E109 L110 M111 D112 A113 L168 I24 V32 A45 M100 E101 L102 M103 D104 A105 L160 D151 K153 N156 D169 T188 D143 K145 N148 D161 T180 2.7.11.24 0004672,0004707,0005524,0006468 ic50=120nM -logKd/Ki=6.92, IC50=120nM P45984 18801372 1 QFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQPTVRNYVENRPAYPGIAFEELFPDWIFPSERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIHAIEEWKELIYKEVM 3e7o B 2.14 BS01 35F B 1 V40 M111 D112 A113 L168 V30 M101 D102 A103 L158 D151 K153 N156 D169 T188 D141 K143 N146 D159 T162 2.7.11.24 0004672,0004707,0005524,0006468 ic50=120nM P45984 18801372 2 SQFYSVQVADSTFTVLKRYQQLKPIGSGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQPTVRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAAPPPQIREHAIEEWKELIYKEVMD