3e12 A 1.7 BS01 CU A 1 C11 H185 E222 D233 C10 H184 E216 D227 2.5.1.55 0005737,0005829,0008676,0009058,0009103,0016740,0019294,0046364 O66496 19228070 270 EKFLVIAGPCAIESEELLLKVGEEIKRLSEKFKEVEFVFKSSFDKANRSSIHSFRGHGLEYGVKALRKVKEEFGLKITTDIHESWQAEPVAEVADIIQIPAFLCRQTDLLLAAAKTGRAVNVKKGQFLAPWDTKNVVEKLKFGGAKEIYLTERGTTFGYNNLVVDFRSLPIMKQWAKVIYDATHSVQLPGGGGMREFIFPLIRAAVAVGCDGVFMETHPEPEKALSDASTQLPLSQLEGIIEAILEIREVASKYYETI 3e12 A 1.7 BS02 PO4 A 1 P101 A102 K124 R154 P100 A101 K123 R153 2.5.1.55 0005737,0005829,0008676,0009058,0009103,0016740,0019294,0046364 O66496 19228070 269 EKFLVIAGPCAIESEELLLKVGEEIKRLSEKFKEVEFVFKSSFDKANRSSIHSFRGHGLEYGVKALRKVKEEFGLKITTDIHESWQAEPVAEVADIIQIPAFLCRQTDLLLAAAKTGRAVNVKKGQFLAPWDTKNVVEKLKFGGAKEIYLTERGTTFGYNNLVVDFRSLPIMKQWAKVIYDATHSVQLPGGGGMREFIFPLIRAAVAVGCDGVFMETHPEPEKALSDASTQLPLSQLEGIIEAILEIREVASKYYETI 3e12 A 1.7 BS03 KD0 A 1 K41 K46 N48 R49 S50 Q99 K124 H185 D233 K40 K45 N47 R48 S49 Q98 K123 H184 D227 2.5.1.55 0005737,0005829,0008676,0009058,0009103,0016740,0019294,0046364 -logKd/Ki=5.99, Kd=1.02uM O66496 19228070 268 EKFLVIAGPCAIESEELLLKVGEEIKRLSEKFKEVEFVFKSSFDKANRSSIHSFRGHGLEYGVKALRKVKEEFGLKITTDIHESWQAEPVAEVADIIQIPAFLCRQTDLLLAAAKTGRAVNVKKGQFLAPWDTKNVVEKLKFGGAKEIYLTERGTTFGYNNLVVDFRSLPIMKQWAKVIYDATHSVQLPGGGGMREFIFPLIRAAVAVGCDGVFMETHPEPEKALSDASTQLPLSQLEGIIEAILEIREVASKYYETI 3e12 B 1.7 BS01 CU B 1 C11 H185 E222 D233 C9 H183 E214 D225 2.5.1.55 0005737,0005829,0008676,0009058,0009103,0016740,0019294,0046364 O66496 19228070 270 KFLVIAGPCAIESEELLLKVGEEIKRLSEKFKEVEFVFKSSFDKANRSSIHSFRGHGLEYGVKALRKVKEEFGLKITTDIHESWQAEPVAEVADIIQIPAFLCRQTDLLLAAAKTGRAVNVKKGQFLAPWDTKNVVEKLKFGGAKEIYLTERGTTFGYNNLVVDFRSLPIMKQWAKVIYDATHSVQLPGGGMREFIFPLIRAAVAVGCDGVFMETHPEPEKALSDASTQLPLSQLEGIIEAILEIREVASKYYETI 3e12 B 1.7 BS02 PO4 B 1 P101 A102 K124 R154 P99 A100 K122 R152 2.5.1.55 0005737,0005829,0008676,0009058,0009103,0016740,0019294,0046364 O66496 19228070 269 KFLVIAGPCAIESEELLLKVGEEIKRLSEKFKEVEFVFKSSFDKANRSSIHSFRGHGLEYGVKALRKVKEEFGLKITTDIHESWQAEPVAEVADIIQIPAFLCRQTDLLLAAAKTGRAVNVKKGQFLAPWDTKNVVEKLKFGGAKEIYLTERGTTFGYNNLVVDFRSLPIMKQWAKVIYDATHSVQLPGGGMREFIFPLIRAAVAVGCDGVFMETHPEPEKALSDASTQLPLSQLEGIIEAILEIREVASKYYETI 3e12 B 1.7 BS03 KD0 B 1 K41 K46 N48 R49 S50 Q99 K124 H185 D233 K39 K44 N46 R47 S48 Q97 K122 H183 D225 2.5.1.55 0005737,0005829,0008676,0009058,0009103,0016740,0019294,0046364 -logKd/Ki=5.99, Kd=1.02uM O66496 19228070 268 KFLVIAGPCAIESEELLLKVGEEIKRLSEKFKEVEFVFKSSFDKANRSSIHSFRGHGLEYGVKALRKVKEEFGLKITTDIHESWQAEPVAEVADIIQIPAFLCRQTDLLLAAAKTGRAVNVKKGQFLAPWDTKNVVEKLKFGGAKEIYLTERGTTFGYNNLVVDFRSLPIMKQWAKVIYDATHSVQLPGGGMREFIFPLIRAAVAVGCDGVFMETHPEPEKALSDASTQLPLSQLEGIIEAILEIREVASKYYETI