3dv3 A 2.3 BS01 MG A 1 N195 D208 N135 D148 D190 K192 S194 N195 D208 D217 T226 D130 K132 S134 N135 D148 D157 T163 2.7.12.2 0004672,0005524,0006468 Q02750 19019675 1 MELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLN 3dv3 A 2.3 BS02 ATP A 1 A76 G77 N78 V82 A95 K97 M143 M146 Q153 K192 S194 L197 A16 G17 N18 V22 A35 K37 M83 M86 Q93 K132 S134 L137 D190 K192 S194 N195 D208 D217 T226 D130 K132 S134 N135 D148 D157 T163 2.7.12.2 0004672,0005524,0006468 Q02750 19019675 9000 MELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLN 3dv3 A 2.3 BS03 MEK A 1 K97 V127 M143 D208 F209 G210 V211 L215 K37 V67 M83 D148 F149 G150 V151 L155 D190 K192 S194 N195 D208 D217 T226 D130 K132 S134 N135 D148 D157 T163 2.7.12.2 0004672,0005524,0006468 IC50=21nM Q02750 19019675 9001 MELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLN