3dpf A 2.1 BS01 CA A 1 D137 G169 G171 D173 D58 G90 G92 D94 H197 E198 H201 H207 H118 E119 H122 H128 3.4.24.34 0004222,0006508,0008237,0008270,0031012 P22894 19173605 996 MLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYG 3dpf A 2.1 BS02 CA A 2 D154 G155 N157 I159 D177 E180 D75 G76 N78 I80 D98 E101 H197 E198 H201 H207 H118 E119 H122 H128 3.4.24.34 0004222,0006508,0008237,0008270,0031012 P22894 19173605 997 MLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYG 3dpf A 2.1 BS03 ZN A 1 H147 D149 H162 H175 H68 D70 H83 H96 H197 E198 H201 H207 H118 E119 H122 H128 3.4.24.34 0004222,0006508,0008237,0008270,0031012 P22894 19173605 998 MLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYG 3dpf A 2.1 BS04 ZN A 2 H197 H201 H207 H118 H122 H128 H197 E198 H201 H207 H118 E119 H122 H128 3.4.24.34 0004222,0006508,0008237,0008270,0031012 P22894 19173605 999 MLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYG 3dpf A 2.1 BS05 AXB A 1 I159 L160 A161 L193 H197 L214 Y216 P217 N218 Y219 A220 R222 T224 Y227 S228 P230 I80 L81 A82 L114 H118 L135 Y137 P138 N139 Y140 A141 R143 T145 Y148 S149 P151 H197 E198 H201 H207 H118 E119 H122 H128 3.4.24.34 0004222,0006508,0008237,0008270,0031012 -logKd/Ki=7.24, IC50=57nM IC50=57nM P22894 19173605 1 MLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYG 3dpf B 2.1 BS01 CA B 1 D137 G169 I170 G171 D173 D58 G90 I91 G92 D94 H197 E198 H201 H207 H118 E119 H122 H128 3.4.24.34 0004222,0006508,0008237,0008270,0031012 P22894 19173605 996 MLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYG 3dpf B 2.1 BS02 CA B 2 D154 G155 N157 I159 D177 E180 D75 G76 N78 I80 D98 E101 H197 E198 H201 H207 H118 E119 H122 H128 3.4.24.34 0004222,0006508,0008237,0008270,0031012 P22894 19173605 997 MLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYG 3dpf B 2.1 BS03 ZN B 1 H147 D149 H162 H175 H68 D70 H83 H96 H197 E198 H201 H207 H118 E119 H122 H128 3.4.24.34 0004222,0006508,0008237,0008270,0031012 P22894 19173605 998 MLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYG 3dpf B 2.1 BS04 ZN B 2 H197 H201 H207 H118 H122 H128 H197 E198 H201 H207 H118 E119 H122 H128 3.4.24.34 0004222,0006508,0008237,0008270,0031012 P22894 19173605 999 MLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYG 3dpf B 2.1 BS05 AXB B 1 I159 L160 A161 L193 H197 L214 Y216 P217 N218 Y219 A220 R222 Y227 S228 P230 I80 L81 A82 L114 H118 L135 Y137 P138 N139 Y140 A141 R143 Y148 S149 P151 H197 E198 H201 H207 H118 E119 H122 H128 3.4.24.34 0004222,0006508,0008237,0008270,0031012 IC50=57nM P22894 19173605 2 MLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYG