3d94 A 2.3 BS01 CA A 1 E1013 D1129 Y1131 E58 D163 Y165 D1105 R1109 N1110 D1123 E1132 D139 R143 N144 D157 E166 2.7.10.1 0004672,0004713,0004714,0005524,0006468,0007169,0016020 P08069 18566589 2 VYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLLELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEEN 3d94 A 2.3 BS02 D94 A 1 L975 Q977 F980 V983 A1001 K1003 F1017 M1024 V1033 M1049 M1052 D1056 X1112 G1122 D1123 F1124 L20 Q22 F25 V28 A46 K48 F62 M69 V78 M94 M97 D101 X146 G156 D157 F158 D1105 R1109 N1110 D1123 E1132 D139 R143 N144 D157 E166 2.7.10.1 0004672,0004713,0004714,0005524,0006468,0007169,0016020 Ki=157nM -logKd/Ki=6.80, Ki=157nM IC50=19nM P08069 18566589 1 VYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLLELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEEN