3d5q A 2.55 BS01 NAP A 1 G41 S43 K44 G45 I46 A65 R66 S67 T92 M93 N119 H120 I121 V168 S170 Y183 K187 L217 I218 T220 T222 A223 G21 S23 K24 G25 I26 A45 R46 S47 T72 M73 N99 H100 I101 V148 S150 Y163 K167 L197 I198 T200 T202 A203 S170 Y183 K187 S150 Y163 K167 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 P28845 18789704 1 QPLNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYSTSYNMDRF 3d5q A 2.55 BS02 T30 A 1 T124 S125 L126 S170 L171 V175 Y177 V180 Y183 T104 S105 L106 S150 L151 V155 Y157 V160 Y163 S170 Y183 K187 S150 Y163 K167 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 IC50=1.6nM P28845 18789704 293 QPLNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYSTSYNMDRF 3d5q B 2.55 BS01 NAP B 1 G41 S43 K44 G45 I46 A65 R66 S67 T92 M93 N119 I121 V168 S170 Y183 K187 L215 G216 L217 I218 T220 T222 A223 G21 S23 K24 G25 I26 A45 R46 S47 T72 M73 N99 I101 V148 S150 Y163 K167 L195 G196 L197 I198 T200 T202 A203 S170 Y183 K187 S150 Y163 K167 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 P28845 18789704 2 QPLNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYSTSY 3d5q B 2.55 BS02 T30 B 1 T124 S125 L126 S170 L171 Y177 Y183 T104 S105 L106 S150 L151 Y157 Y163 S170 Y183 K187 S150 Y163 K167 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 IC50=1.6nM P28845 18789704 1 QPLNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYSTSY 3d5q C 2.55 BS01 NAP C 1 G41 S43 K44 G45 I46 A65 R66 S67 T92 M93 N119 I121 S170 Y183 K187 L215 L217 I218 T220 T222 A223 G19 S21 K22 G23 I24 A43 R44 S45 T70 M71 N97 I99 S148 Y161 K165 L193 L195 I196 T198 T200 A201 S170 Y183 K187 S148 Y161 K165 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 P28845 18789704 3 LNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYS 3d5q C 2.55 BS02 T30 C 1 T124 S125 S170 L171 Y177 Y183 T102 S103 S148 L149 Y155 Y161 S170 Y183 K187 S148 Y161 K165 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 IC50=1.6nM P28845 18789704 1 LNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYS 3d5q D 2.55 BS01 NAP D 1 G41 S43 K44 I46 R66 M93 N119 I121 S170 Y183 K187 L217 I218 T220 T222 A223 G21 S23 K24 I26 R46 M73 N99 I101 S150 Y163 K167 L197 I198 T200 T202 A203 S170 Y183 K187 S150 Y163 K167 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 P28845 18789704 4 QPLNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYS 3d5q D 2.55 BS02 T30 D 1 T124 S125 S170 L171 V175 Y177 Y183 T104 S105 S150 L151 V155 Y157 Y163 S170 Y183 K187 S150 Y163 K167 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 IC50=1.6nM P28845 18789704 1 QPLNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYS