3d3e A 2.6 BS01 NAP A 1 G41 S43 K44 G45 I46 R66 S67 M93 N119 I121 V168 S170 Y183 K187 L215 G216 I218 T220 T222 A223 G21 S23 K24 G25 I26 R46 S47 M73 N99 I101 V148 S150 Y163 K167 L195 G196 I198 T200 T202 A203 S170 Y183 K187 S150 Y163 K167 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 P28845 18553955 1 QPLNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYSTSY 3d3e A 2.6 BS02 D3E A 1 T124 L126 S170 L171 Y177 M179 Y183 G216 A223 T104 L106 S150 L151 Y157 M159 Y163 G196 A203 S170 Y183 K187 S150 Y163 K167 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 IC50=1.4nM P28845 18553955 293 QPLNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYSTSY 3d3e B 2.6 BS01 NAP B 1 G41 S43 K44 G45 I46 A65 R66 S67 T92 M93 N119 I121 V168 S170 Y183 K187 L215 I218 T220 T222 A223 G21 S23 K24 G25 I26 A45 R46 S47 T72 M73 N99 I101 V148 S150 Y163 K167 L195 I198 T200 T202 A203 S170 Y183 K187 S150 Y163 K167 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 P28845 18553955 2 QPLNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYS 3d3e B 2.6 BS02 D3E B 1 T124 L126 S170 L171 Y177 Y183 A226 T104 L106 S150 L151 Y157 Y163 A206 S170 Y183 K187 S150 Y163 K167 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 IC50=1.4nM P28845 18553955 293 QPLNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYS 3d3e C 2.6 BS01 NAP C 1 G41 S43 K44 G45 I46 R66 S67 T92 M93 N119 I121 S170 Y183 K187 L215 G216 L217 I218 T220 T222 G21 S23 K24 G25 I26 R46 S47 T72 M73 N99 I101 S150 Y163 K167 L195 G196 L197 I198 T200 T202 S170 Y183 K187 S150 Y163 K167 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 P28845 18553955 3 QPLNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYS 3d3e C 2.6 BS02 D3E C 1 T124 L126 S170 L171 Y177 M179 Y183 G216 A226 T104 L106 S150 L151 Y157 M159 Y163 G196 A206 S170 Y183 K187 S150 Y163 K167 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 IC50=1.4nM P28845 18553955 293 QPLNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYS 3d3e D 2.6 BS01 NAP D 1 G41 S43 K44 G45 I46 R66 S67 M93 N119 I121 V168 S170 Y183 K187 G216 I218 T220 T222 A223 G21 S23 K24 G25 I26 R46 S47 M73 N99 I101 V148 S150 Y163 K167 G196 I198 T200 T202 A203 S170 Y183 K187 S150 Y163 K167 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 P28845 18553955 4 QPLNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYS 3d3e D 2.6 BS02 D3E D 1 T124 L126 S170 M179 Y183 G216 A226 T104 L106 S150 M159 Y163 G196 A206 S170 Y183 K187 S150 Y163 K167 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 IC50=1.4nM P28845 18553955 293 QPLNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYS