3cy2 A 2.01 BS01 peptide B 0 D128 F130 D131 I133 T134 D167 D170 E171 D202 T204 V206 G238 D239 E243 D94 F96 D97 I99 T100 D133 D136 E137 D168 T170 V172 G204 D205 E209 D167 K169 N172 D186 L193 T204 D133 K135 N138 D152 L159 T170 2.7.11.1 0004672,0004674,0005515,0005524,0005634,0005654,0005730,0005737,0005829,0005886,0006338,0006468,0006915,0008134,0016310,0022898,0030145,0043024,0043066,0043433,0044024,0045824,0045893,0046777,0046872,0050821,0060045,0070561,0071346,0090336,0106310,1902033,1904263,1905062,1990748 P11309 22136433 2 ~ 10 PLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIGGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLH 3cy2 A 2.01 BS02 MB9 A 1 F49 V52 A65 K67 R122 N172 L174 I185 D186 F17 V20 A33 K35 R88 N138 L140 I151 D152 D167 K169 N172 D186 L193 T204 D133 K135 N138 D152 L159 T170 2.7.11.1 0004672,0004674,0005515,0005524,0005634,0005654,0005730,0005737,0005829,0005886,0006338,0006468,0006915,0008134,0016310,0022898,0030145,0043024,0043066,0043433,0044024,0045824,0045893,0046777,0046872,0050821,0060045,0070561,0071346,0090336,0106310,1902033,1904263,1905062,1990748 ic50=60nM -logKd/Ki=7.22, IC50=60nM P11309 22136433 501 PLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIGGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLH