3c56 A 2.3 BS01 ZN A 1 H83 H180 H210 H83 H170 H200 C69 E70 G136 H180 A226 N253 C69 E70 G136 H170 A216 N243 4.1.2.13 0004332,0005975,0006096,0008270,0016829,0016832,0030388,0046872 P56109 18688832 308 MLVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERYPHIPVALHLDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIAVLVNPKEAEQFVKESQVDYLAPAIGTSHGAFKFKGEPKLDFERLQEVKRLTNIPLVLHGASAIPDNVRKSYLDAGGDLKGSKGVPFEFLQESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANKI 3c56 A 2.3 BS02 PH4 A 1 N23 S49 D82 H180 K184 G211 S213 N253 D255 T256 R259 N23 S49 D82 H170 K174 G201 S203 N243 D245 T246 R249 C69 E70 G136 H180 A226 N253 C69 E70 G136 H170 A216 N243 4.1.2.13 0004332,0005975,0006096,0008270,0016829,0016832,0030388,0046872 Ki=0.013uM -logKd/Ki=7.89, Ki=0.013uM Ki=13nM P56109 18688832 309 MLVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERYPHIPVALHLDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIAVLVNPKEAEQFVKESQVDYLAPAIGTSHGAFKFKGEPKLDFERLQEVKRLTNIPLVLHGASAIPDNVRKSYLDAGGDLKGSKGVPFEFLQESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANKI 3c56 B 2.3 BS01 ZN B 1 H83 H180 H210 H83 H167 H197 C69 E70 G136 H180 A226 N253 C69 E70 G136 H167 A213 N240 4.1.2.13 0004332,0005975,0006096,0008270,0016829,0016832,0030388,0046872 P56109 18688832 308 MLVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERYPHIPVALHLDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMVLVNPKEAEQFVKESQVDYLAPAIGTSHGAFKFKGEPKLDFERLQEVKRLTNIPLVLHGASAIPDNVRKSYLDAGGDLKGSKGVPFEFLQESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANKI 3c56 B 2.3 BS02 PH4 B 1 N23 S49 D82 H180 K184 H210 G211 A212 S213 N253 D255 T256 R259 N23 S49 D82 H167 K171 H197 G198 A199 S200 N240 D242 T243 R246 C69 E70 G136 H180 A226 N253 C69 E70 G136 H167 A213 N240 4.1.2.13 0004332,0005975,0006096,0008270,0016829,0016832,0030388,0046872 Ki=0.013uM -logKd/Ki=7.89, Ki=0.013uM Ki=13nM P56109 18688832 309 MLVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERYPHIPVALHLDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMVLVNPKEAEQFVKESQVDYLAPAIGTSHGAFKFKGEPKLDFERLQEVKRLTNIPLVLHGASAIPDNVRKSYLDAGGDLKGSKGVPFEFLQESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANKI