3bb1 A 2.8 BS01 GNP A 1 G49 V50 G51 K52 S53 S54 S68 P69 S72 G96 H163 E210 N211 G48 V49 G50 K51 S52 S53 S67 P68 S71 G95 H162 E204 N205 3.6.5.- 0005525,0006886,0009707,0015450 -logKd/Ki=3.60, Kd=0.25mM Q41009 18400179 281 ASQQQTVRGWSGINTFAPATQTKLLELLGNLKQEDVNSLTILVMGKGGVGKSSTVNSIIGERVVSISPFQSEGPRPVMVSRSRAGFTLNIIDTPGLIEGGYINDMALNIIKSFLLDKTIDVLLYVDRLDAYRVDNLDKLVAKAITDSFGKGIWNKAIVALTHAQFSPPDGLPYDEFFSKRSEALLQVVRSGASLKSDIPVVLIENSGRCNKNDSDEKVLPNGIAWIPHLVQTITEVALNKSESIFVDKNLID 3bb1 A 2.8 BS02 GNP B 1 Y132 R133 P169 Y131 R132 P168 3.6.5.- 0005525,0006886,0009707,0015450 -logKd/Ki=3.60, Kd=0.25mM Q41009 18400179 281 ASQQQTVRGWSGINTFAPATQTKLLELLGNLKQEDVNSLTILVMGKGGVGKSSTVNSIIGERVVSISPFQSEGPRPVMVSRSRAGFTLNIIDTPGLIEGGYINDMALNIIKSFLLDKTIDVLLYVDRLDAYRVDNLDKLVAKAITDSFGKGIWNKAIVALTHAQFSPPDGLPYDEFFSKRSEALLQVVRSGASLKSDIPVVLIENSGRCNKNDSDEKVLPNGIAWIPHLVQTITEVALNKSESIFVDKNLID 3bb1 B 2.8 BS01 GNP A 1 Y132 R133 P169 Y124 R125 P161 3.6.5.- 0005525,0006886,0009707,0015450 -logKd/Ki=3.60, Kd=0.25mM Q41009 18400179 281 VRGWSGINTFAPATQTKLLELLGNLKQEDVNSLTILVMGKGGVGKSSTVNSIIGERVVSISPFQSGPRPVMVSRSRAGFTLNIIDTPGLIEGGYINDMALNIIKSFLLDKTIDVLLYVDRLDAYRVDNLDKLVAKAITDSFGKGIWNKAIVALTHAQFSPPDGLPYDEFFSKRSEALLQVVRSGASLASDIPVVLIENSGRCNSDEKVLPNGIAWIPHLVQTITEVALNKSESIFVDKNLIDG 3bb1 B 2.8 BS02 GNP B 1 G49 G51 K52 S53 S54 P69 S72 H163 E210 N211 G42 G44 K45 S46 S47 P62 S65 H155 E197 N198 3.6.5.- 0005525,0006886,0009707,0015450 -logKd/Ki=3.60, Kd=0.25mM Q41009 18400179 281 VRGWSGINTFAPATQTKLLELLGNLKQEDVNSLTILVMGKGGVGKSSTVNSIIGERVVSISPFQSGPRPVMVSRSRAGFTLNIIDTPGLIEGGYINDMALNIIKSFLLDKTIDVLLYVDRLDAYRVDNLDKLVAKAITDSFGKGIWNKAIVALTHAQFSPPDGLPYDEFFSKRSEALLQVVRSGASLASDIPVVLIENSGRCNSDEKVLPNGIAWIPHLVQTITEVALNKSESIFVDKNLIDG 3bb1 C 2.8 BS01 GNP C 1 G49 V50 G51 K52 S53 S54 I67 S68 P69 H163 E210 N211 G42 V43 G44 K45 S46 S47 I60 S61 P62 H156 E198 N199 3.6.5.- 0005525,0006886,0009707,0015450 Q41009 18400179 281 VRGWSGINTFAPATQTKLLELLGNLKQEDVNSLTILVMGKGGVGKSSTVNSIIGERVVSISPFQSEGPRPVMVSRSRAGFTLNIIDTPGLIEGGYINDMALNIIKSFLLDKTIDVLLYVDRLDAYRVDNLDKLVAKAITDSFGKGIWNKAIVALTHAQFSPPDGLPYDEFFSKRSEALLQVVRSGASLKSDIPVVLIENSGRCNKNDSDEKVLPNGIAWIPHLVQTITEVALNKSESIFVDKNLID 3bb1 C 2.8 BS02 GNP D 1 Y132 R133 Y125 R126 3.6.5.- 0005525,0006886,0009707,0015450 Q41009 18400179 281 VRGWSGINTFAPATQTKLLELLGNLKQEDVNSLTILVMGKGGVGKSSTVNSIIGERVVSISPFQSEGPRPVMVSRSRAGFTLNIIDTPGLIEGGYINDMALNIIKSFLLDKTIDVLLYVDRLDAYRVDNLDKLVAKAITDSFGKGIWNKAIVALTHAQFSPPDGLPYDEFFSKRSEALLQVVRSGASLKSDIPVVLIENSGRCNKNDSDEKVLPNGIAWIPHLVQTITEVALNKSESIFVDKNLID 3bb1 D 2.8 BS01 GNP C 1 Y132 P169 D170 Y126 P163 D164 3.6.5.- 0005525,0006886,0009707,0015450 Q41009 18400179 281 TVRGWSGINTFAPATQTKLLELLGNLKQEDVNSLTILVMGKGGVGKSSTVNSIIGERVVSISPFQSEGPRPVMVSRSRAGFTLNIIDTPGLIEGGYINDMALNIIKSFLLDKTIDVLLYVDRLDAYRVDNLDKLVAKAITDSFGKGIWNKAIVALTHAQFSPPDGLPYDEFFSKRSEALLQVVRSGASLKKDAASDIPVVLIENSGRCNDEKVLPNGIAWIPHLVQTITEVALNKSESIFVDKNLID 3bb1 D 2.8 BS02 GNP D 1 G49 G51 K52 S53 S54 P69 H163 E210 N211 G43 G45 K46 S47 S48 P63 H157 E203 N204 3.6.5.- 0005525,0006886,0009707,0015450 Q41009 18400179 281 TVRGWSGINTFAPATQTKLLELLGNLKQEDVNSLTILVMGKGGVGKSSTVNSIIGERVVSISPFQSEGPRPVMVSRSRAGFTLNIIDTPGLIEGGYINDMALNIIKSFLLDKTIDVLLYVDRLDAYRVDNLDKLVAKAITDSFGKGIWNKAIVALTHAQFSPPDGLPYDEFFSKRSEALLQVVRSGASLKKDAASDIPVVLIENSGRCNDEKVLPNGIAWIPHLVQTITEVALNKSESIFVDKNLID 3bb1 E 2.8 BS01 GNP E 1 G49 G51 K52 S53 S54 I67 S68 P69 H163 E210 N211 G42 G44 K45 S46 S47 I60 S61 P62 H156 E200 N201 3.6.5.- 0005525,0006886,0009707,0015450 Q41009 18400179 281 VRGWSGINTFAPATQTKLLELLGNLKQEDVNSLTILVMGKGGVGKSSTVNSIIGERVVSISPFQSEGPRPVMVSRSRAGFTLNIIDTPGLIEGGYINDMALNIIKSFLLDKTIDVLLYVDRLDAYRVDNLDKLVAKAITDSFGKGIWNKAIVALTHAQFSPPDGLPYDEFFSKRSEALLQVVRSGASLKKASDIPVVLIENSGRCNKNDSDEKVLPNGIAWIPHLVQTITEVALNKSESIFVDKNLID 3bb1 E 2.8 BS02 GNP F 1 Y132 R133 P169 Y125 R126 P162 3.6.5.- 0005525,0006886,0009707,0015450 Q41009 18400179 281 VRGWSGINTFAPATQTKLLELLGNLKQEDVNSLTILVMGKGGVGKSSTVNSIIGERVVSISPFQSEGPRPVMVSRSRAGFTLNIIDTPGLIEGGYINDMALNIIKSFLLDKTIDVLLYVDRLDAYRVDNLDKLVAKAITDSFGKGIWNKAIVALTHAQFSPPDGLPYDEFFSKRSEALLQVVRSGASLKKASDIPVVLIENSGRCNKNDSDEKVLPNGIAWIPHLVQTITEVALNKSESIFVDKNLID 3bb1 F 2.8 BS01 GNP E 1 Y132 R133 P169 D170 Y125 R126 P162 D163 3.6.5.- 0005525,0006886,0009707,0015450 Q41009 18400179 281 VRGWSGINTFAPATQTKLLELLGNLKQEDVNSLTILVMGKGGVGKSSTVNSIIGERVVSISPFQSEGPRPVMVSRSRAGFTLNIIDTPGLIEGGYINDMALNIIKSFLLDKTIDVLLYVDRLDAYRVDNLDKLVAKAITDSFGKGIWNKAIVALTHAQFSPPDGLPYDEFFSKRSEALLQVVRSGASLKKDIPVVLIENSGRCNKNDSDEKVLPNGIAWIPHLVQTITEVALNKSESIFVDKNLI 3bb1 F 2.8 BS02 GNP F 1 G48 G49 G51 K52 S53 S54 I67 S68 P69 S72 H163 E210 N211 G41 G42 G44 K45 S46 S47 I60 S61 P62 S65 H156 E198 N199 3.6.5.- 0005525,0006886,0009707,0015450 Q41009 18400179 281 VRGWSGINTFAPATQTKLLELLGNLKQEDVNSLTILVMGKGGVGKSSTVNSIIGERVVSISPFQSEGPRPVMVSRSRAGFTLNIIDTPGLIEGGYINDMALNIIKSFLLDKTIDVLLYVDRLDAYRVDNLDKLVAKAITDSFGKGIWNKAIVALTHAQFSPPDGLPYDEFFSKRSEALLQVVRSGASLKKDIPVVLIENSGRCNKNDSDEKVLPNGIAWIPHLVQTITEVALNKSESIFVDKNLI 3bb1 G 2.8 BS01 GNP G 1 G49 G51 K52 S53 S54 S68 G96 H163 E210 N211 G48 G50 K51 S52 S53 S67 G95 H162 E203 N204 3.6.5.- 0005525,0006886,0009707,0015450 Q41009 18400179 281 ASQQQTVRGWSGINTFAPATQTKLLELLGNLKQEDVNSLTILVMGKGGVGKSSTVNSIIGERVVSISPFQSEGPRPVMVSRSRAGFTLNIIDTPGLIEGGYINDMALNIIKSFLLDKTIDVLLYVDRLDAYRVDNLDKLVAKAITDSFGKGIWNKAIVALTHAQFSPPDGLPYDEFFSKRSEALLQVVRSGASLSDIPVVLIENSGRCNKNDSDEKVLPNGIAWIPHLVQTITEVALNKSESIFVDKNLID 3bb1 G 2.8 BS02 GNP H 1 Y132 R133 P169 Y131 R132 P168 3.6.5.- 0005525,0006886,0009707,0015450 Q41009 18400179 281 ASQQQTVRGWSGINTFAPATQTKLLELLGNLKQEDVNSLTILVMGKGGVGKSSTVNSIIGERVVSISPFQSEGPRPVMVSRSRAGFTLNIIDTPGLIEGGYINDMALNIIKSFLLDKTIDVLLYVDRLDAYRVDNLDKLVAKAITDSFGKGIWNKAIVALTHAQFSPPDGLPYDEFFSKRSEALLQVVRSGASLSDIPVVLIENSGRCNKNDSDEKVLPNGIAWIPHLVQTITEVALNKSESIFVDKNLID 3bb1 H 2.8 BS01 GNP G 1 Y132 R133 P169 D170 Y125 R126 P162 D163 3.6.5.- 0005525,0006886,0009707,0015450 Q41009 18400179 281 VRGWSGINTFAPATQTKLLELLGNLKQEDVNSLTILVMGKGGVGKSSTVNSIIGERVVSISPFQSEGPRPVMVSRSRAGFTLNIIDTPGLIEGGYINDMALNIIKSFLLDKTIDVLLYVDRLDAYRVDNLDKLVAKAITDSFGKGIWNKAIVALTHAQFSPPDGLPYDEFFSKRSEALLQVVRSGASLKKDSDIPVVLIENSGRCNKNDSDEKVLPNGIAWIPHLVQTITEVALNKSESIFVDKNLID 3bb1 H 2.8 BS02 GNP H 1 G48 G49 V50 G51 K52 S53 S54 P69 H163 E210 N211 G41 G42 V43 G44 K45 S46 S47 P62 H156 E200 N201 3.6.5.- 0005525,0006886,0009707,0015450 Q41009 18400179 281 VRGWSGINTFAPATQTKLLELLGNLKQEDVNSLTILVMGKGGVGKSSTVNSIIGERVVSISPFQSEGPRPVMVSRSRAGFTLNIIDTPGLIEGGYINDMALNIIKSFLLDKTIDVLLYVDRLDAYRVDNLDKLVAKAITDSFGKGIWNKAIVALTHAQFSPPDGLPYDEFFSKRSEALLQVVRSGASLKKDSDIPVVLIENSGRCNKNDSDEKVLPNGIAWIPHLVQTITEVALNKSESIFVDKNLID