3b99 A 2.5 BS01 HEM A 1 Q94 K119 F126 V273 T274 N277 R339 P413 W414 G415 N419 C421 P422 G423 I465 Q74 K99 F106 V253 T254 N257 R307 P379 W380 G381 N385 C387 P388 G389 I431 4.2.1.152,5.3.99.4 0001516,0004497,0005506,0005783,0005789,0008116,0016020,0016705,0016829,0016853,0020037,0046872,0106256 F1RE08 18032380 600 RRTRRRNEPPLDKGMIPWLGHALEFGKDAAKFLTRMKEKHGDIFTVRAAGLYITVLLDSNCYDAVLSDVASLDQTSYAQVLMKRIFNMILPSHNPESEKKRAEMHFQGASLTQLSNSMQNNLRLLMTPSEMGLKTSEWKKDGLFNLCYSLLFKTGYLTVFGAENNNSAALTQIYEEFRRFDKLLPKLARTTVNKEEKQIASAAREKLWKWLTPSGLDRKPREQSWLGSYVKQLQDEGIDAEMQRRAMLLQLWVTQGNAGPAAFWVMGYLLTHPEALRAVREEIQNTPVFDSVLWETLRLTAAALITRDVTQDKKICLSNGQEYHLRRGDRLCVFPFISPQMDPQIHQQPEMFQFDRFLNATEKKDFFKNGARVKYPSVPWGTEDNLCPGRHFAVHAIKELVFTILTRFDVELCDKNATVPLVDPSRYGFGILQPAGDLEIRYRIR 3b99 A 2.5 BS02 U51 A 1 Q94 W272 N277 L336 I337 T338 Q74 W252 N257 L304 I305 T306 4.2.1.152,5.3.99.4 0001516,0004497,0005506,0005783,0005789,0008116,0016020,0016705,0016829,0016853,0020037,0046872,0106256 Kd=1.9uM F1RE08 18032380 700 RRTRRRNEPPLDKGMIPWLGHALEFGKDAAKFLTRMKEKHGDIFTVRAAGLYITVLLDSNCYDAVLSDVASLDQTSYAQVLMKRIFNMILPSHNPESEKKRAEMHFQGASLTQLSNSMQNNLRLLMTPSEMGLKTSEWKKDGLFNLCYSLLFKTGYLTVFGAENNNSAALTQIYEEFRRFDKLLPKLARTTVNKEEKQIASAAREKLWKWLTPSGLDRKPREQSWLGSYVKQLQDEGIDAEMQRRAMLLQLWVTQGNAGPAAFWVMGYLLTHPEALRAVREEIQNTPVFDSVLWETLRLTAAALITRDVTQDKKICLSNGQEYHLRRGDRLCVFPFISPQMDPQIHQQPEMFQFDRFLNATEKKDFFKNGARVKYPSVPWGTEDNLCPGRHFAVHAIKELVFTILTRFDVELCDKNATVPLVDPSRYGFGILQPAGDLEIRYRIR 3b99 A 2.5 BS03 U51 A 2 A98 Q99 L101 M102 L110 H113 W272 A78 Q79 L81 M82 L90 H93 W252 4.2.1.152,5.3.99.4 0001516,0004497,0005506,0005783,0005789,0008116,0016020,0016705,0016829,0016853,0020037,0046872,0106256 Kd=1.9uM F1RE08 18032380 701 RRTRRRNEPPLDKGMIPWLGHALEFGKDAAKFLTRMKEKHGDIFTVRAAGLYITVLLDSNCYDAVLSDVASLDQTSYAQVLMKRIFNMILPSHNPESEKKRAEMHFQGASLTQLSNSMQNNLRLLMTPSEMGLKTSEWKKDGLFNLCYSLLFKTGYLTVFGAENNNSAALTQIYEEFRRFDKLLPKLARTTVNKEEKQIASAAREKLWKWLTPSGLDRKPREQSWLGSYVKQLQDEGIDAEMQRRAMLLQLWVTQGNAGPAAFWVMGYLLTHPEALRAVREEIQNTPVFDSVLWETLRLTAAALITRDVTQDKKICLSNGQEYHLRRGDRLCVFPFISPQMDPQIHQQPEMFQFDRFLNATEKKDFFKNGARVKYPSVPWGTEDNLCPGRHFAVHAIKELVFTILTRFDVELCDKNATVPLVDPSRYGFGILQPAGDLEIRYRIR 3b99 A 2.5 BS04 U51 A 3 F45 A68 Y97 R104 L336 R362 C364 G462 F463 F25 A48 Y77 R84 L304 R330 C332 G428 F429 4.2.1.152,5.3.99.4 0001516,0004497,0005506,0005783,0005789,0008116,0016020,0016705,0016829,0016853,0020037,0046872,0106256 Kd=1.9uM F1RE08 18032380 702 RRTRRRNEPPLDKGMIPWLGHALEFGKDAAKFLTRMKEKHGDIFTVRAAGLYITVLLDSNCYDAVLSDVASLDQTSYAQVLMKRIFNMILPSHNPESEKKRAEMHFQGASLTQLSNSMQNNLRLLMTPSEMGLKTSEWKKDGLFNLCYSLLFKTGYLTVFGAENNNSAALTQIYEEFRRFDKLLPKLARTTVNKEEKQIASAAREKLWKWLTPSGLDRKPREQSWLGSYVKQLQDEGIDAEMQRRAMLLQLWVTQGNAGPAAFWVMGYLLTHPEALRAVREEIQNTPVFDSVLWETLRLTAAALITRDVTQDKKICLSNGQEYHLRRGDRLCVFPFISPQMDPQIHQQPEMFQFDRFLNATEKKDFFKNGARVKYPSVPWGTEDNLCPGRHFAVHAIKELVFTILTRFDVELCDKNATVPLVDPSRYGFGILQPAGDLEIRYRIR 3b99 B 2.5 BS01 HEM B 1 Q94 F126 V273 T274 N277 R339 P413 W414 C421 P422 G423 I465 Q74 F106 V221 T222 N225 R275 P349 W350 C357 P358 G359 I401 4.2.1.152,5.3.99.4 0001516,0004497,0005506,0005783,0005789,0008116,0016020,0016705,0016829,0016853,0020037,0046872,0106256 F1RE08 18032380 600 RRTRRRNEPPLDKGMIPWLGHALEFGKDAAKFLTRMKEKHGDIFTVRAAGLYITVLLDSNCYDAVLSDVASLDQTSYAQVLMKRIFNMILPSHNPESEKKRAEMHFQGASLTQLSNSMQNNLRLLMTPSEMWKKDGLFNLCYSLLFKTGYLTVFTQIYEEFRRFDKLLPKLARTEKQIASAAREKLWKWLTSWLGSYVKQLQDEGIDAEMQRRAMLLQLWVTQGNAGPAAFWVMGYLLTHPEALRAVREEIQNTPVFDSVLWETLRLTAAALITRDVTQDKKICLSNGQEYHLRRGDRLCVFPFISPQMDPQIHQQPEMFQFDRFLNADRTEKKDFFKNGARVKYPSVPWGTEDNLCPGRHFAVHAIKELVFTILTRFDVELCDKNATVPLVDPSRYGFGILQPAGDLEIRYRIR 3b99 B 2.5 BS02 U51 B 1 Q94 A98 V273 N277 A335 I337 T338 G462 Q74 A78 V221 N225 A271 I273 T274 G398 4.2.1.152,5.3.99.4 0001516,0004497,0005506,0005783,0005789,0008116,0016020,0016705,0016829,0016853,0020037,0046872,0106256 Kd=1.9uM F1RE08 18032380 700 RRTRRRNEPPLDKGMIPWLGHALEFGKDAAKFLTRMKEKHGDIFTVRAAGLYITVLLDSNCYDAVLSDVASLDQTSYAQVLMKRIFNMILPSHNPESEKKRAEMHFQGASLTQLSNSMQNNLRLLMTPSEMWKKDGLFNLCYSLLFKTGYLTVFTQIYEEFRRFDKLLPKLARTEKQIASAAREKLWKWLTSWLGSYVKQLQDEGIDAEMQRRAMLLQLWVTQGNAGPAAFWVMGYLLTHPEALRAVREEIQNTPVFDSVLWETLRLTAAALITRDVTQDKKICLSNGQEYHLRRGDRLCVFPFISPQMDPQIHQQPEMFQFDRFLNADRTEKKDFFKNGARVKYPSVPWGTEDNLCPGRHFAVHAIKELVFTILTRFDVELCDKNATVPLVDPSRYGFGILQPAGDLEIRYRIR 3b99 B 2.5 BS03 U51 B 2 L101 E118 W245 Y249 Q270 W272 L81 E98 W193 Y197 Q218 W220 4.2.1.152,5.3.99.4 0001516,0004497,0005506,0005783,0005789,0008116,0016020,0016705,0016829,0016853,0020037,0046872,0106256 Kd=1.9uM F1RE08 18032380 701 RRTRRRNEPPLDKGMIPWLGHALEFGKDAAKFLTRMKEKHGDIFTVRAAGLYITVLLDSNCYDAVLSDVASLDQTSYAQVLMKRIFNMILPSHNPESEKKRAEMHFQGASLTQLSNSMQNNLRLLMTPSEMWKKDGLFNLCYSLLFKTGYLTVFTQIYEEFRRFDKLLPKLARTEKQIASAAREKLWKWLTSWLGSYVKQLQDEGIDAEMQRRAMLLQLWVTQGNAGPAAFWVMGYLLTHPEALRAVREEIQNTPVFDSVLWETLRLTAAALITRDVTQDKKICLSNGQEYHLRRGDRLCVFPFISPQMDPQIHQQPEMFQFDRFLNADRTEKKDFFKNGARVKYPSVPWGTEDNLCPGRHFAVHAIKELVFTILTRFDVELCDKNATVPLVDPSRYGFGILQPAGDLEIRYRIR 3b99 B 2.5 BS04 U51 B 3 F45 I73 Y97 R209 R362 G462 F463 F25 I53 Y77 R173 R298 G398 F399 4.2.1.152,5.3.99.4 0001516,0004497,0005506,0005783,0005789,0008116,0016020,0016705,0016829,0016853,0020037,0046872,0106256 Kd=1.9uM F1RE08 18032380 702 RRTRRRNEPPLDKGMIPWLGHALEFGKDAAKFLTRMKEKHGDIFTVRAAGLYITVLLDSNCYDAVLSDVASLDQTSYAQVLMKRIFNMILPSHNPESEKKRAEMHFQGASLTQLSNSMQNNLRLLMTPSEMWKKDGLFNLCYSLLFKTGYLTVFTQIYEEFRRFDKLLPKLARTEKQIASAAREKLWKWLTSWLGSYVKQLQDEGIDAEMQRRAMLLQLWVTQGNAGPAAFWVMGYLLTHPEALRAVREEIQNTPVFDSVLWETLRLTAAALITRDVTQDKKICLSNGQEYHLRRGDRLCVFPFISPQMDPQIHQQPEMFQFDRFLNADRTEKKDFFKNGARVKYPSVPWGTEDNLCPGRHFAVHAIKELVFTILTRFDVELCDKNATVPLVDPSRYGFGILQPAGDLEIRYRIR