3anl A 2.1 BS01 NDP A 1 G7 T9 G10 S11 I12 A34 G35 K36 N37 D56 A99 I100 V101 A104 A122 K124 D149 M275 G8 T10 G11 S12 I13 A35 G36 K37 N38 D57 A100 I101 V102 A105 A123 K125 D150 M276 1.1.1.267 0008299,0016491,0019288,0030145,0030604,0042802,0046872,0051484,0070402,1990065 P45568 21379374 701 GKQLTILGSTGSIGCSTLDVVRHNPEHFRVVALVAGKNVTRMVEQCLEFSPRYAVMDDEASAKLLKTMLQQQGSRTEVLSGQQAACDMAALEDVDQVMAAIVGAAGLLPTLAAIRAGKTILLANKESLVTCGRLFMDAVKQSKAQLLPVDSEHNAIFQSLPQPIQHNLGYADLEQNGVVSILLTGSGGPFRETPLRDLATMTPDQACRHPNWSMGRKISVDSATMMNKGLEYIEARWLFNASASQMEVLIHPQSVIHSMVRYQDGSVLAQLGEPDMRTPIAHTMAWPNRVNSGVKPLDFCKLSALTFAAPDYDRYPCLKLAMEAFEQGQAATTALNAANEITVAAFLAQQIRFTDIAALNLSVLEKMDMREPQCVDDVLSVDANAREVARKEVMRLASSA 3anl A 2.1 BS02 SYC A 1 G184 S185 H208 W211 S221 N226 K227 S253 G185 S186 H209 W212 S222 N227 K228 S254 1.1.1.267 0008299,0016491,0019288,0030145,0030604,0042802,0046872,0051484,0070402,1990065 ic50=4.6uM IC50=4600nM P45568 21379374 800 GKQLTILGSTGSIGCSTLDVVRHNPEHFRVVALVAGKNVTRMVEQCLEFSPRYAVMDDEASAKLLKTMLQQQGSRTEVLSGQQAACDMAALEDVDQVMAAIVGAAGLLPTLAAIRAGKTILLANKESLVTCGRLFMDAVKQSKAQLLPVDSEHNAIFQSLPQPIQHNLGYADLEQNGVVSILLTGSGGPFRETPLRDLATMTPDQACRHPNWSMGRKISVDSATMMNKGLEYIEARWLFNASASQMEVLIHPQSVIHSMVRYQDGSVLAQLGEPDMRTPIAHTMAWPNRVNSGVKPLDFCKLSALTFAAPDYDRYPCLKLAMEAFEQGQAATTALNAANEITVAAFLAQQIRFTDIAALNLSVLEKMDMREPQCVDDVLSVDANAREVARKEVMRLASSA 3anl B 2.1 BS01 NDP B 1 G7 T9 G10 S11 I12 A34 G35 K36 N37 D56 A99 I100 V101 A104 A122 N123 K124 D149 M275 G8 T10 G11 S12 I13 A35 G36 K37 N38 D57 A100 I101 V102 A105 A123 N124 K125 D150 M276 1.1.1.267 0008299,0016491,0019288,0030145,0030604,0042802,0046872,0051484,0070402,1990065 P45568 21379374 702 GKQLTILGSTGSIGCSTLDVVRHNPEHFRVVALVAGKNVTRMVEQCLEFSPRYAVMDDEASAKLLKTMLQQQGSRTEVLSGQQAACDMAALEDVDQVMAAIVGAAGLLPTLAAIRAGKTILLANKESLVTCGRLFMDAVKQSKAQLLPVDSEHNAIFQSLPQPIQHNLGYADLEQNGVVSILLTGSGGPFRETPLRDLATMTPDQACRHPNWSMGRKISVDSATMMNKGLEYIEARWLFNASASQMEVLIHPQSVIHSMVRYQDGSVLAQLGEPDMRTPIAHTMAWPNRVNSGVKPLDFCKLSALTFAAPDYDRYPCLKLAMEAFEQGQAATTALNAANEITVAAFLAQQIRFTDIAALNLSVLEKMDMREPQCVDDVLSVDANAREVARKEVMRLAS 3anl B 2.1 BS02 SYC B 1 G184 S185 H208 N210 W211 K227 G185 S186 H209 N211 W212 K228 1.1.1.267 0008299,0016491,0019288,0030145,0030604,0042802,0046872,0051484,0070402,1990065 ic50=4.6uM IC50=4600nM P45568 21379374 801 GKQLTILGSTGSIGCSTLDVVRHNPEHFRVVALVAGKNVTRMVEQCLEFSPRYAVMDDEASAKLLKTMLQQQGSRTEVLSGQQAACDMAALEDVDQVMAAIVGAAGLLPTLAAIRAGKTILLANKESLVTCGRLFMDAVKQSKAQLLPVDSEHNAIFQSLPQPIQHNLGYADLEQNGVVSILLTGSGGPFRETPLRDLATMTPDQACRHPNWSMGRKISVDSATMMNKGLEYIEARWLFNASASQMEVLIHPQSVIHSMVRYQDGSVLAQLGEPDMRTPIAHTMAWPNRVNSGVKPLDFCKLSALTFAAPDYDRYPCLKLAMEAFEQGQAATTALNAANEITVAAFLAQQIRFTDIAALNLSVLEKMDMREPQCVDDVLSVDANAREVARKEVMRLAS