2zj0 A 2.42 BS01 2FA A 1 H69 T71 Q73 T74 D156 E218 T219 D252 H363 L407 G415 H416 M421 F425 H60 T62 Q64 T65 D147 E209 T210 D243 H354 L398 G406 H407 M412 F416 H69 S92 S97 D156 E218 N243 K248 D252 N253 T257 H363 H416 S424 Q428 H60 S83 S88 D147 E209 N234 K239 D243 N244 T248 H354 H407 S415 Q419 3.13.2.1 0004013,0005515,0005576,0005737,0005829,0005886,0006730,0009087,0009274,0016787,0033353,0035375,0035635,0044650,0046085,0070403,0071269 ic50=66uM P9WGV3 18815415 500 SLTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLRREYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDATMLVLRGMQYEKAGVVPPAEEDDPAEWKVFLNLLRTRFETDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFDVVTVEEAIGDADIVVTATGNKDIIMLEHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYLGVDVEGPYKPDHYRY 2zj0 A 2.42 BS02 NAD A 1 T219 T220 T221 N253 G284 D285 V286 E305 I306 N310 T338 N340 I343 I361 H363 N409 H416 T210 T211 T212 N244 G275 D276 V277 E296 I297 N301 T329 N331 I334 I352 H354 N400 H407 H69 S92 S97 D156 E218 N243 K248 D252 N253 T257 H363 H416 S424 Q428 H60 S83 S88 D147 E209 N234 K239 D243 N244 T248 H354 H407 S415 Q419 3.13.2.1 0004013,0005515,0005576,0005737,0005829,0005886,0006730,0009087,0009274,0016787,0033353,0035375,0035635,0044650,0046085,0070403,0071269 P9WGV3 18815415 550 SLTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLRREYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDATMLVLRGMQYEKAGVVPPAEEDDPAEWKVFLNLLRTRFETDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFDVVTVEEAIGDADIVVTATGNKDIIMLEHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYLGVDVEGPYKPDHYRY 2zj0 A 2.42 BS03 NAD B 1 K489 Y493 K480 Y484 H69 S92 S97 D156 E218 N243 K248 D252 N253 T257 H363 H416 S424 Q428 H60 S83 S88 D147 E209 N234 K239 D243 N244 T248 H354 H407 S415 Q419 3.13.2.1 0004013,0005515,0005576,0005737,0005829,0005886,0006730,0009087,0009274,0016787,0033353,0035375,0035635,0044650,0046085,0070403,0071269 P9WGV3 18815415 550 SLTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLRREYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDATMLVLRGMQYEKAGVVPPAEEDDPAEWKVFLNLLRTRFETDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFDVVTVEEAIGDADIVVTATGNKDIIMLEHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYLGVDVEGPYKPDHYRY 2zj0 B 2.42 BS01 NAD A 1 K489 Y493 K479 Y483 H69 S92 S97 D156 E218 N243 K248 D252 N253 T257 H363 H416 S424 Q428 H59 S82 S87 D146 E208 N233 K238 D242 N243 T247 H353 H406 S414 Q418 3.13.2.1 0004013,0005515,0005576,0005737,0005829,0005886,0006730,0009087,0009274,0016787,0033353,0035375,0035635,0044650,0046085,0070403,0071269 P9WGV3 18815415 550 LTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLRREYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDATMLVLRGMQYEKAGVVPPAEEDDPAEWKVFLNLLRTRFETDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFDVVTVEEAIGDADIVVTATGNKDIIMLEHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYLGVDVEGPYKPDHYRY 2zj0 B 2.42 BS02 2FA B 1 H69 T71 Q73 D156 E218 T219 D252 H363 G415 H416 M421 F425 H59 T61 Q63 D146 E208 T209 D242 H353 G405 H406 M411 F415 H69 S92 S97 D156 E218 N243 K248 D252 N253 T257 H363 H416 S424 Q428 H59 S82 S87 D146 E208 N233 K238 D242 N243 T247 H353 H406 S414 Q418 3.13.2.1 0004013,0005515,0005576,0005737,0005829,0005886,0006730,0009087,0009274,0016787,0033353,0035375,0035635,0044650,0046085,0070403,0071269 ic50=66uM P9WGV3 18815415 500 LTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLRREYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDATMLVLRGMQYEKAGVVPPAEEDDPAEWKVFLNLLRTRFETDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFDVVTVEEAIGDADIVVTATGNKDIIMLEHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYLGVDVEGPYKPDHYRY 2zj0 B 2.42 BS03 NAD B 1 T219 T220 T221 N253 G282 G284 D285 V286 T304 E305 I306 T338 I361 H363 N409 H416 T209 T210 T211 N243 G272 G274 D275 V276 T294 E295 I296 T328 I351 H353 N399 H406 H69 S92 S97 D156 E218 N243 K248 D252 N253 T257 H363 H416 S424 Q428 H59 S82 S87 D146 E208 N233 K238 D242 N243 T247 H353 H406 S414 Q418 3.13.2.1 0004013,0005515,0005576,0005737,0005829,0005886,0006730,0009087,0009274,0016787,0033353,0035375,0035635,0044650,0046085,0070403,0071269 P9WGV3 18815415 550 LTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLRREYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDATMLVLRGMQYEKAGVVPPAEEDDPAEWKVFLNLLRTRFETDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFDVVTVEEAIGDADIVVTATGNKDIIMLEHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYLGVDVEGPYKPDHYRY 2zj0 C 2.42 BS01 2FA C 1 L68 H69 T71 T74 D156 E218 T219 D252 H363 L410 G415 H416 M421 F425 L58 H59 T61 T64 D146 E208 T209 D242 H353 L400 G405 H406 M411 F415 H69 S92 S97 D156 E218 N243 K248 D252 N253 T257 H363 H416 S424 Q428 H59 S82 S87 D146 E208 N233 K238 D242 N243 T247 H353 H406 S414 Q418 3.13.2.1 0004013,0005515,0005576,0005737,0005829,0005886,0006730,0009087,0009274,0016787,0033353,0035375,0035635,0044650,0046085,0070403,0071269 ic50=66uM P9WGV3 18815415 500 LTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLRREYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDATMLVLRGMQYEKAGVVPPAEEDDPAEWKVFLNLLRTRFETDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFDVVTVEEAIGDADIVVTATGNKDIIMLEHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYLGVDVEGPYKPDHYRY 2zj0 C 2.42 BS02 NAD C 1 T219 T220 T221 N253 G284 D285 V286 T304 E305 I306 N310 T338 G339 N340 I343 I361 G362 H363 N409 H416 T209 T210 T211 N243 G274 D275 V276 T294 E295 I296 N300 T328 G329 N330 I333 I351 G352 H353 N399 H406 H69 S92 S97 D156 E218 N243 K248 D252 N253 T257 H363 H416 S424 Q428 H59 S82 S87 D146 E208 N233 K238 D242 N243 T247 H353 H406 S414 Q418 3.13.2.1 0004013,0005515,0005576,0005737,0005829,0005886,0006730,0009087,0009274,0016787,0033353,0035375,0035635,0044650,0046085,0070403,0071269 P9WGV3 18815415 550 LTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLRREYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDATMLVLRGMQYEKAGVVPPAEEDDPAEWKVFLNLLRTRFETDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFDVVTVEEAIGDADIVVTATGNKDIIMLEHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYLGVDVEGPYKPDHYRY 2zj0 C 2.42 BS03 NAD D 1 K489 Y493 K479 Y483 H69 S92 S97 D156 E218 N243 K248 D252 N253 T257 H363 H416 S424 Q428 H59 S82 S87 D146 E208 N233 K238 D242 N243 T247 H353 H406 S414 Q418 3.13.2.1 0004013,0005515,0005576,0005737,0005829,0005886,0006730,0009087,0009274,0016787,0033353,0035375,0035635,0044650,0046085,0070403,0071269 P9WGV3 18815415 550 LTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLRREYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDATMLVLRGMQYEKAGVVPPAEEDDPAEWKVFLNLLRTRFETDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFDVVTVEEAIGDADIVVTATGNKDIIMLEHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYLGVDVEGPYKPDHYRY 2zj0 D 2.42 BS01 NAD C 1 K489 Y493 K479 Y483 H69 S92 S97 D156 E218 N243 K248 D252 N253 T257 H363 H416 S424 Q428 H59 S82 S87 D146 E208 N233 K238 D242 N243 T247 H353 H406 S414 Q418 3.13.2.1 0004013,0005515,0005576,0005737,0005829,0005886,0006730,0009087,0009274,0016787,0033353,0035375,0035635,0044650,0046085,0070403,0071269 P9WGV3 18815415 550 LTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLRREYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDATMLVLRGMQYEKAGVVPPAEEDDPAEWKVFLNLLRTRFETDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFDVVTVEEAIGDADIVVTATGNKDIIMLEHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYLGVDVEGPYKPDHYRY 2zj0 D 2.42 BS02 2FA D 1 H69 T71 Q73 T74 D156 E218 T219 K248 D252 H363 L410 G415 H416 M421 F425 H59 T61 Q63 T64 D146 E208 T209 K238 D242 H353 L400 G405 H406 M411 F415 H69 S92 S97 D156 E218 N243 K248 D252 N253 T257 H363 H416 S424 Q428 H59 S82 S87 D146 E208 N233 K238 D242 N243 T247 H353 H406 S414 Q418 3.13.2.1 0004013,0005515,0005576,0005737,0005829,0005886,0006730,0009087,0009274,0016787,0033353,0035375,0035635,0044650,0046085,0070403,0071269 ic50=66uM P9WGV3 18815415 500 LTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLRREYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDATMLVLRGMQYEKAGVVPPAEEDDPAEWKVFLNLLRTRFETDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFDVVTVEEAIGDADIVVTATGNKDIIMLEHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYLGVDVEGPYKPDHYRY 2zj0 D 2.42 BS03 NAD D 1 T219 T220 T221 N253 G282 G284 V286 T304 E305 I306 N310 T338 G339 N340 I343 I361 G362 H363 N409 H416 T209 T210 T211 N243 G272 G274 V276 T294 E295 I296 N300 T328 G329 N330 I333 I351 G352 H353 N399 H406 H69 S92 S97 D156 E218 N243 K248 D252 N253 T257 H363 H416 S424 Q428 H59 S82 S87 D146 E208 N233 K238 D242 N243 T247 H353 H406 S414 Q418 3.13.2.1 0004013,0005515,0005576,0005737,0005829,0005886,0006730,0009087,0009274,0016787,0033353,0035375,0035635,0044650,0046085,0070403,0071269 P9WGV3 18815415 550 LTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLRREYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDATMLVLRGMQYEKAGVVPPAEEDDPAEWKVFLNLLRTRFETDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFDVVTVEEAIGDADIVVTATGNKDIIMLEHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYLGVDVEGPYKPDHYRY