2zis A 2.6 BS01 FPP B 1 K164 Y166 K110 Y112 K164 K110 2.5.1.58,2.5.1.59 0004659,0004660,0004661,0004662,0004663,0005515,0005737,0005875,0005953,0005965,0007167,0008017,0008270,0008284,0008318,0014070,0018342,0018343,0018344,0030971,0034097,0035022,0036094,0042277,0043014,0043066,0045787,0051770,0051771,0060090,0090044,1901363,1904395 Q04631 19217288 902 FLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYITAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHS 2zis B 2.6 BS01 ZN B 1 D297 C299 H362 D276 C278 H341 H248 R291 K294 D297 C299 Y300 D352 D359 H362 H227 R270 K273 D276 C278 Y279 D331 D338 H341 2.5.1.58 0003824,0004311,0004659,0004660,0005515,0005875,0005965,0006629,0008270,0008283,0008284,0008285,0008318,0014070,0018343,0034097,0042060,0042277,0045787,0046872,0048144,0048145,0048146,0051770 Q02293 19217288 901 PLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPG 2zis B 2.6 BS02 FPP B 1 R202 Y205 H248 G250 Y251 C254 R291 K294 Y300 W303 R181 Y184 H227 G229 Y230 C233 R270 K273 Y279 W282 H248 R291 K294 D297 C299 Y300 D352 D359 H362 H227 R270 K273 D276 C278 Y279 D331 D338 H341 2.5.1.58 0003824,0004311,0004659,0004660,0005515,0005875,0005965,0006629,0008270,0008283,0008284,0008285,0008318,0014070,0018343,0034097,0042060,0042277,0045787,0046872,0048144,0048145,0048146,0051770 Q02293 19217288 902 PLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPG 2zis B 2.6 BS03 NH8 B 1 L96 W102 W106 R202 D297 C299 D359 Y361 H362 L75 W81 W85 R181 D276 C278 D338 Y340 H341 H248 R291 K294 D297 C299 Y300 D352 D359 H362 H227 R270 K273 D276 C278 Y279 D331 D338 H341 2.5.1.58 0003824,0004311,0004659,0004660,0005515,0005875,0005965,0006629,0008270,0008283,0008284,0008285,0008318,0014070,0018343,0034097,0042060,0042277,0045787,0046872,0048144,0048145,0048146,0051770 -logKd/Ki=8.55, IC50=2.8nM Q02293 19217288 903 PLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPG