2z7i A 2.1 BS01 MG A 1 D80 D84 D77 D81 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005737,0005739,0008299,0015031,0016114,0016740,0033384,0033386,0045337,0046872 Q12051 18800762 1301 NKMEAKIDELINNDPVWSSQNESLISKPYNHILLKPGKNFRLNLIVQINRVMNLPKDQLAIVSQIVELLHNSSLLIDDIEDNAPLRRGQTTSHLIFGVPSTINTANYMYFRAMQLVSQLTTKEPLYHNLITIFNEELINLHRGQGLDIYWRDFLPEIIPTQEMYLNMVMNKTGGLFRLTLRLMEALSPSGHSLVPFINLLGIIYQIRDDYLNLKDFQFAEDITEGKLSFPIVHALNFTKTKGQTEQHNEILRILLLRTSDKDIKLKLIQILEFDTNSLAYTKNFINQLVNMIKNENKYLPDELLYIIDHLSEL 2z7i A 2.1 BS02 742 A 1 R44 H73 D80 R89 K174 F179 T182 I203 Q211 D214 K238 R41 H70 D77 R86 K171 F176 T179 I197 Q205 D208 K226 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005737,0005739,0008299,0015031,0016114,0016740,0033384,0033386,0045337,0046872 ic50=0.1uM -logKd/Ki=7.00, IC50=0.10uM Q12051 18800762 1302 NKMEAKIDELINNDPVWSSQNESLISKPYNHILLKPGKNFRLNLIVQINRVMNLPKDQLAIVSQIVELLHNSSLLIDDIEDNAPLRRGQTTSHLIFGVPSTINTANYMYFRAMQLVSQLTTKEPLYHNLITIFNEELINLHRGQGLDIYWRDFLPEIIPTQEMYLNMVMNKTGGLFRLTLRLMEALSPSGHSLVPFINLLGIIYQIRDDYLNLKDFQFAEDITEGKLSFPIVHALNFTKTKGQTEQHNEILRILLLRTSDKDIKLKLIQILEFDTNSLAYTKNFINQLVNMIKNENKYLPDELLYIIDHLSEL 2z7i B 2.1 BS01 MG B 1 D80 D84 D77 D81 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005737,0005739,0008299,0015031,0016114,0016740,0033384,0033386,0045337,0046872 Q12051 18800762 1302 NKMEAKIDELINNDPVWSSQNESLISKPYNHILLKPGKNFRLNLIVQINRVMNLPKDQLAIVSQIVELLHNSSLLIDDIEDNAPLRRGQTTSHLIFGVPSTINTANYMYFRAMQLVSQLTTKEPLYHNLITIFNEELINLHRGQGLDIYWRDFLPEIIPTQEMYLNMVMNKTGGLFRLTLRLMEALSPSSHSLVPFINLLGIIYQIRDDYLNLKDFQMSFAEDITEGKLSFPIVHALNFTKTKGQTEQHNEILRILLLRTSDKDIKLKLIQILEFDTNSLAYTKNFINQLVNMIKNDNENKYLPDELLYIIDHLSEL 2z7i B 2.1 BS02 742 B 1 R44 L47 H73 D80 R89 K174 F179 T182 Y210 Q211 D214 K238 R41 L44 H70 D77 R86 K171 F176 T179 Y204 Q205 D208 K228 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005737,0005739,0008299,0015031,0016114,0016740,0033384,0033386,0045337,0046872 ic50=0.1uM Q12051 18800762 1303 NKMEAKIDELINNDPVWSSQNESLISKPYNHILLKPGKNFRLNLIVQINRVMNLPKDQLAIVSQIVELLHNSSLLIDDIEDNAPLRRGQTTSHLIFGVPSTINTANYMYFRAMQLVSQLTTKEPLYHNLITIFNEELINLHRGQGLDIYWRDFLPEIIPTQEMYLNMVMNKTGGLFRLTLRLMEALSPSSHSLVPFINLLGIIYQIRDDYLNLKDFQMSFAEDITEGKLSFPIVHALNFTKTKGQTEQHNEILRILLLRTSDKDIKLKLIQILEFDTNSLAYTKNFINQLVNMIKNDNENKYLPDELLYIIDHLSEL