2z4w A 2.45 BS01 MG A 1 D80 D84 D74 D78 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005737,0005739,0008299,0015031,0016114,0016740,0033384,0033386,0045337,0046872 Q12051 18800762 1301 NKMEAKIDELINNDPVWSSQNESLISKPYNHILLKNFRLNLIVQINRVMNLPKDQLAIVSQIVELLHNSSLLIDDIEDNAPLRRGQTTSHLIFGVPSTINTANYMYFRAMQLVSQLTTKEPLYHNLITIFNEELINLHRGQGLDIYWRDFLPEIIPTQEMYLNMVMNKTGGLFRLTLRLMEALSPSGHSLVPFINLLGIIYQIRDDYLNLKDFQFAEDITEGKLSFPIVHALNFTKTKGQTEQHNEILRILLLRTSDKDIKLKLIQILEFDTNSLAYTKNFINQLVNMIKND 2z4w A 2.45 BS02 MG A 2 D80 D84 D74 D78 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005737,0005739,0008299,0015031,0016114,0016740,0033384,0033386,0045337,0046872 Q12051 18800762 1302 NKMEAKIDELINNDPVWSSQNESLISKPYNHILLKNFRLNLIVQINRVMNLPKDQLAIVSQIVELLHNSSLLIDDIEDNAPLRRGQTTSHLIFGVPSTINTANYMYFRAMQLVSQLTTKEPLYHNLITIFNEELINLHRGQGLDIYWRDFLPEIIPTQEMYLNMVMNKTGGLFRLTLRLMEALSPSGHSLVPFINLLGIIYQIRDDYLNLKDFQFAEDITEGKLSFPIVHALNFTKTKGQTEQHNEILRILLLRTSDKDIKLKLIQILEFDTNSLAYTKNFINQLVNMIKND 2z4w A 2.45 BS03 749 A 1 R44 H73 D80 R89 L143 Q147 K174 Y210 D214 K238 R38 H67 D74 R83 L137 Q141 K168 Y201 D205 K223 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005737,0005739,0008299,0015031,0016114,0016740,0033384,0033386,0045337,0046872 ic50=0.98uM -logKd/Ki=6.01, IC50=0.98uM Q12051 18800762 1101 NKMEAKIDELINNDPVWSSQNESLISKPYNHILLKNFRLNLIVQINRVMNLPKDQLAIVSQIVELLHNSSLLIDDIEDNAPLRRGQTTSHLIFGVPSTINTANYMYFRAMQLVSQLTTKEPLYHNLITIFNEELINLHRGQGLDIYWRDFLPEIIPTQEMYLNMVMNKTGGLFRLTLRLMEALSPSGHSLVPFINLLGIIYQIRDDYLNLKDFQFAEDITEGKLSFPIVHALNFTKTKGQTEQHNEILRILLLRTSDKDIKLKLIQILEFDTNSLAYTKNFINQLVNMIKND 2z4w B 2.45 BS01 MG B 1 D80 D84 D72 D76 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005737,0005739,0008299,0015031,0016114,0016740,0033384,0033386,0045337,0046872 Q12051 18800762 1303 NKMEAKIDELINNDPVWSSQNESLISKPYNHILLFRLNLIVQINRVMNLPKDQLAIVSQIVELLHNSSLLIDDIEDNAPLRRGQTTSHLIFGVPSTINTANYMYFRAMQLVSQLTTKEPLYHNLITIFNEELINLHRGQGLDIYWRDFLPEIIPTQEMYLNMVMNKTGGLFRLTLRLMEALSPSHSLVPFINLLGIIYQIRDDYLNLKDFQFAEDITEGKLSFPIVHALNFTKTKGQTEQHNEILRILLLRTSDKDIKLKLIQILEFDTNSLAYTKNFINQLVNMIKNDNENKYLP 2z4w B 2.45 BS02 MG B 2 D80 D84 D72 D76 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005737,0005739,0008299,0015031,0016114,0016740,0033384,0033386,0045337,0046872 Q12051 18800762 1304 NKMEAKIDELINNDPVWSSQNESLISKPYNHILLFRLNLIVQINRVMNLPKDQLAIVSQIVELLHNSSLLIDDIEDNAPLRRGQTTSHLIFGVPSTINTANYMYFRAMQLVSQLTTKEPLYHNLITIFNEELINLHRGQGLDIYWRDFLPEIIPTQEMYLNMVMNKTGGLFRLTLRLMEALSPSHSLVPFINLLGIIYQIRDDYLNLKDFQFAEDITEGKLSFPIVHALNFTKTKGQTEQHNEILRILLLRTSDKDIKLKLIQILEFDTNSLAYTKNFINQLVNMIKNDNENKYLP 2z4w B 2.45 BS03 749 B 1 H73 S76 D80 R89 L143 Q147 K174 F179 Y210 D214 K238 H65 S68 D72 R81 L135 Q139 K166 F171 Y198 D202 K220 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005737,0005739,0008299,0015031,0016114,0016740,0033384,0033386,0045337,0046872 ic50=0.98uM -logKd/Ki=6.01, IC50=0.98uM Q12051 18800762 1102 NKMEAKIDELINNDPVWSSQNESLISKPYNHILLFRLNLIVQINRVMNLPKDQLAIVSQIVELLHNSSLLIDDIEDNAPLRRGQTTSHLIFGVPSTINTANYMYFRAMQLVSQLTTKEPLYHNLITIFNEELINLHRGQGLDIYWRDFLPEIIPTQEMYLNMVMNKTGGLFRLTLRLMEALSPSHSLVPFINLLGIIYQIRDDYLNLKDFQFAEDITEGKLSFPIVHALNFTKTKGQTEQHNEILRILLLRTSDKDIKLKLIQILEFDTNSLAYTKNFINQLVNMIKNDNENKYLP