2yoo A 1.69 BS01 HEM A 1 E56 I79 H86 R90 I141 G233 G234 T237 T238 V280 R285 A335 F336 G337 F338 H341 C343 L344 G345 E52 I75 H82 R86 I137 G229 G230 T233 T234 V276 R281 A331 F332 G333 F334 H337 C339 L340 G341 C164 G233 E236 T237 T238 C343 L344 G345 E352 V383 C160 G229 E232 T233 T234 C339 L340 G341 E348 V379 1.14.15.28 0004497,0005506,0006707,0008203,0008395,0016042,0016705,0020037,0036199,0046872 A0R4Q6 23489718 1402 LTRPDVDLVNGMFYADGGAREAYRWMRANEPVFRDRNGLAAATTYQAVLDAERNPELFSSTGGIRPDQPGMPYMIDMDDPQHLLRRKLVNAGFTRKRVMDKVDSIGRLCDTLIDAVCERGECDFVRDIAAPLPMAVIGDMLGVLPTERDMLLKWSDDLVCGLSSHVDEAAIQKLMDTFAAYTEFTKDVITKRRAEPTDDLFSVLVNSEVEGQRMSDDEIVFETLLILIGGDETTRHTLSGGTEQLLRHRDQWDALVADVDLLPGAIEEMLRWTSPVKNMCRTLTADTVFHGTELRAGEKIMLMFESANFDESVFGDPDNFRIDRNPNSHVAFGFGTHFCLGNQLARLELRLMTERVLRRLPDLRLADDAPVPLRPANFVSGPESMPVVFTPSAPVL 2yoo A 1.69 BS02 K2B A 1 Q72 M75 M179 F182 L229 I232 F382 Q68 M71 M175 F178 L225 I228 F378 C164 G233 E236 T237 T238 C343 L344 G345 E352 V383 C160 G229 E232 T233 T234 C339 L340 G341 E348 V379 1.14.15.28 0004497,0005506,0006707,0008203,0008395,0016042,0016705,0020037,0036199,0046872 Kd=0.52uM A0R4Q6 23489718 1404 LTRPDVDLVNGMFYADGGAREAYRWMRANEPVFRDRNGLAAATTYQAVLDAERNPELFSSTGGIRPDQPGMPYMIDMDDPQHLLRRKLVNAGFTRKRVMDKVDSIGRLCDTLIDAVCERGECDFVRDIAAPLPMAVIGDMLGVLPTERDMLLKWSDDLVCGLSSHVDEAAIQKLMDTFAAYTEFTKDVITKRRAEPTDDLFSVLVNSEVEGQRMSDDEIVFETLLILIGGDETTRHTLSGGTEQLLRHRDQWDALVADVDLLPGAIEEMLRWTSPVKNMCRTLTADTVFHGTELRAGEKIMLMFESANFDESVFGDPDNFRIDRNPNSHVAFGFGTHFCLGNQLARLELRLMTERVLRRLPDLRLADDAPVPLRPANFVSGPESMPVVFTPSAPVL 2yoo B 1.69 BS01 HEM B 1 E56 I79 H86 R90 F97 L229 G233 G234 T237 T238 V280 M283 R285 A335 F336 G337 F338 H341 C343 L344 G345 A349 E51 I74 H81 R85 F92 L224 G228 G229 T232 T233 V275 M278 R280 A330 F331 G332 F333 H336 C338 L339 G340 A344 C164 G233 E236 T237 T238 C343 L344 G345 E352 V383 C159 G228 E231 T232 T233 C338 L339 G340 E347 V378 1.14.15.28 0004497,0005506,0006707,0008203,0008395,0016042,0016705,0020037,0036199,0046872 A0R4Q6 23489718 1402 TRPDVDLVNGMFYADGGAREAYRWMRANEPVFRDRNGLAAATTYQAVLDAERNPELFSSTGGIRPDQPGMPYMIDMDDPQHLLRRKLVNAGFTRKRVMDKVDSIGRLCDTLIDAVCERGECDFVRDIAAPLPMAVIGDMLGVLPTERDMLLKWSDDLVCGLSSHVDEAAIQKLMDTFAAYTEFTKDVITKRRAEPTDDLFSVLVNSEVEGQRMSDDEIVFETLLILIGGDETTRHTLSGGTEQLLRHRDQWDALVADVDLLPGAIEEMLRWTSPVKNMCRTLTADTVFHGTELRAGEKIMLMFESANFDESVFGDPDNFRIDRNPNSHVAFGFGTHFCLGNQLARLELRLMTERVLRRLPDLRLADDAPVPLRPANFVSGPESMPVVFTPSAPVL 2yoo B 1.69 BS02 K2B B 1 Q72 M179 F182 L228 I232 F382 Q67 M174 F177 L223 I227 F377 C164 G233 E236 T237 T238 C343 L344 G345 E352 V383 C159 G228 E231 T232 T233 C338 L339 G340 E347 V378 1.14.15.28 0004497,0005506,0006707,0008203,0008395,0016042,0016705,0020037,0036199,0046872 Kd=0.52uM A0R4Q6 23489718 1404 TRPDVDLVNGMFYADGGAREAYRWMRANEPVFRDRNGLAAATTYQAVLDAERNPELFSSTGGIRPDQPGMPYMIDMDDPQHLLRRKLVNAGFTRKRVMDKVDSIGRLCDTLIDAVCERGECDFVRDIAAPLPMAVIGDMLGVLPTERDMLLKWSDDLVCGLSSHVDEAAIQKLMDTFAAYTEFTKDVITKRRAEPTDDLFSVLVNSEVEGQRMSDDEIVFETLLILIGGDETTRHTLSGGTEQLLRHRDQWDALVADVDLLPGAIEEMLRWTSPVKNMCRTLTADTVFHGTELRAGEKIMLMFESANFDESVFGDPDNFRIDRNPNSHVAFGFGTHFCLGNQLARLELRLMTERVLRRLPDLRLADDAPVPLRPANFVSGPESMPVVFTPSAPVL 2yoo C 1.69 BS01 HEM C 1 E56 I79 H86 R90 F97 I141 L229 I230 G233 G234 T237 T238 V280 R285 A335 F336 G337 F338 H341 C343 L344 G345 E51 I74 H81 R85 F92 I136 L224 I225 G228 G229 T232 T233 V275 R280 A330 F331 G332 F333 H336 C338 L339 G340 C164 G233 E236 T237 T238 C343 L344 G345 E352 V383 C159 G228 E231 T232 T233 C338 L339 G340 E347 V378 1.14.15.28 0004497,0005506,0006707,0008203,0008395,0016042,0016705,0020037,0036199,0046872 A0R4Q6 23489718 1402 TRPDVDLVNGMFYADGGAREAYRWMRANEPVFRDRNGLAAATTYQAVLDAERNPELFSSTGGIRPDQPGMPYMIDMDDPQHLLRRKLVNAGFTRKRVMDKVDSIGRLCDTLIDAVCERGECDFVRDIAAPLPMAVIGDMLGVLPTERDMLLKWSDDLVCGLSSHVDEAAIQKLMDTFAAYTEFTKDVITKRRAEPTDDLFSVLVNSEVEGQRMSDDEIVFETLLILIGGDETTRHTLSGGTEQLLRHRDQWDALVADVDLLPGAIEEMLRWTSPVKNMCRTLTADTVFHGTELRAGEKIMLMFESANFDESVFGDPDNFRIDRNPNSHVAFGFGTHFCLGNQLARLELRLMTERVLRRLPDLRLADDAPVPLRPANFVSGPESMPVVFTPSAPVL 2yoo C 1.69 BS02 K2B C 1 Y77 F182 L228 L229 F382 Y72 F177 L223 L224 F377 C164 G233 E236 T237 T238 C343 L344 G345 E352 V383 C159 G228 E231 T232 T233 C338 L339 G340 E347 V378 1.14.15.28 0004497,0005506,0006707,0008203,0008395,0016042,0016705,0020037,0036199,0046872 Kd=0.52uM A0R4Q6 23489718 1404 TRPDVDLVNGMFYADGGAREAYRWMRANEPVFRDRNGLAAATTYQAVLDAERNPELFSSTGGIRPDQPGMPYMIDMDDPQHLLRRKLVNAGFTRKRVMDKVDSIGRLCDTLIDAVCERGECDFVRDIAAPLPMAVIGDMLGVLPTERDMLLKWSDDLVCGLSSHVDEAAIQKLMDTFAAYTEFTKDVITKRRAEPTDDLFSVLVNSEVEGQRMSDDEIVFETLLILIGGDETTRHTLSGGTEQLLRHRDQWDALVADVDLLPGAIEEMLRWTSPVKNMCRTLTADTVFHGTELRAGEKIMLMFESANFDESVFGDPDNFRIDRNPNSHVAFGFGTHFCLGNQLARLELRLMTERVLRRLPDLRLADDAPVPLRPANFVSGPESMPVVFTPSAPVL 2yoo D 1.69 BS01 HEM D 1 E56 I79 H86 R90 F97 G233 G234 T237 T238 V280 M283 R285 A335 F336 G337 F338 H341 C343 L344 G345 E51 I74 H81 R85 F92 G228 G229 T232 T233 V275 M278 R280 A330 F331 G332 F333 H336 C338 L339 G340 C164 G233 E236 T237 T238 C343 L344 G345 E352 V383 C159 G228 E231 T232 T233 C338 L339 G340 E347 V378 1.14.15.28 0004497,0005506,0006707,0008203,0008395,0016042,0016705,0020037,0036199,0046872 A0R4Q6 23489718 1402 TRPDVDLVNGMFYADGGAREAYRWMRANEPVFRDRNGLAAATTYQAVLDAERNPELFSSTGGIRPDQPGMPYMIDMDDPQHLLRRKLVNAGFTRKRVMDKVDSIGRLCDTLIDAVCERGECDFVRDIAAPLPMAVIGDMLGVLPTERDMLLKWSDDLVCGLSSHVDEAAIQKLMDTFAAYTEFTKDVITKRRAEPTDDLFSVLVNSEVEGQRMSDDEIVFETLLILIGGDETTRHTLSGGTEQLLRHRDQWDALVADVDLLPGAIEEMLRWTSPVKNMCRTLTADTVFHGTELRAGEKIMLMFESANFDESVFGDPDNFRIDRNPNSHVAFGFGTHFCLGNQLARLELRLMTERVLRRLPDLRLADDAPVPLRPANFVSGPESMPVVFTPSAPV 2yoo D 1.69 BS02 K2B D 1 M179 F182 L229 I232 F382 M174 F177 L224 I227 F377 C164 G233 E236 T237 T238 C343 L344 G345 E352 V383 C159 G228 E231 T232 T233 C338 L339 G340 E347 V378 1.14.15.28 0004497,0005506,0006707,0008203,0008395,0016042,0016705,0020037,0036199,0046872 Kd=0.52uM A0R4Q6 23489718 1404 TRPDVDLVNGMFYADGGAREAYRWMRANEPVFRDRNGLAAATTYQAVLDAERNPELFSSTGGIRPDQPGMPYMIDMDDPQHLLRRKLVNAGFTRKRVMDKVDSIGRLCDTLIDAVCERGECDFVRDIAAPLPMAVIGDMLGVLPTERDMLLKWSDDLVCGLSSHVDEAAIQKLMDTFAAYTEFTKDVITKRRAEPTDDLFSVLVNSEVEGQRMSDDEIVFETLLILIGGDETTRHTLSGGTEQLLRHRDQWDALVADVDLLPGAIEEMLRWTSPVKNMCRTLTADTVFHGTELRAGEKIMLMFESANFDESVFGDPDNFRIDRNPNSHVAFGFGTHFCLGNQLARLELRLMTERVLRRLPDLRLADDAPVPLRPANFVSGPESMPVVFTPSAPV