2yme A 2.4 BS01 CWB A 1 Y91 W145 C188 Y193 Y91 W145 C188 Y193 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=343uM Q8WSF8 23196367 1207 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWERQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRER 2yme A 2.4 BS02 CWB E 1 W53 R55 I116 W53 R55 I116 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=343uM Q8WSF8 23196367 1207 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWERQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRER 2yme B 2.4 BS01 CWB A 1 W53 R55 W53 R55 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=343uM Q8WSF8 23196367 1207 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWERQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRER 2yme B 2.4 BS02 CWB B 1 Y91 W145 C188 Y193 Y91 W145 C188 Y193 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=343uM Q8WSF8 23196367 1207 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWERQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRER 2yme C 2.4 BS01 CWB B 1 W53 R55 W53 R55 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=343uM Q8WSF8 23196367 1207 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWERQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRER 2yme C 2.4 BS02 CWB C 1 Y91 W145 Y186 C188 C189 Y193 Y91 W145 Y186 C188 C189 Y193 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=343uM Q8WSF8 23196367 1207 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWERQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRER 2yme D 2.4 BS01 CWB C 1 W53 R55 I116 W53 R55 I116 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=343uM Q8WSF8 23196367 1207 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWERQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRER 2yme D 2.4 BS02 CWB D 1 Y91 W145 C188 Y193 Y91 W145 C188 Y193 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=343uM Q8WSF8 23196367 1207 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWERQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRER 2yme E 2.4 BS01 CWB D 1 W53 R55 I116 W53 R55 I116 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=343uM Q8WSF8 23196367 1207 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWERQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRER 2yme E 2.4 BS02 CWB E 1 W145 Y186 C188 Y193 W145 Y186 C188 Y193 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=343uM Q8WSF8 23196367 1207 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWERQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRER 2yme F 2.4 BS01 CWB F 1 W145 Y186 C188 Y193 W145 Y186 C188 Y193 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=343uM -logKd/Ki=7.66, Kd=22nM Q8WSF8 23196367 1207 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWERQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRER 2yme G 2.4 BS01 CWB F 1 W53 R55 I116 W53 R55 I116 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=343uM -logKd/Ki=7.66, Kd=22nM Q8WSF8 23196367 1207 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWERQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRER 2yme G 2.4 BS02 CWB G 1 Y91 W145 C188 C189 Y193 Y91 W145 C188 C189 Y193 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=343uM -logKd/Ki=7.66, Kd=22nM Q8WSF8 23196367 1207 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWERQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRER 2yme H 2.4 BS01 CWB G 1 W53 R55 I116 W53 R55 I116 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=343uM Q8WSF8 23196367 1207 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWERQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRER 2yme H 2.4 BS02 CWB H 1 Y91 W145 C188 C189 Y193 Y91 W145 C188 C189 Y193 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=343uM Q8WSF8 23196367 1207 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWERQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRER 2yme I 2.4 BS01 CWB H 1 R55 I116 R55 I116 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=343uM Q8WSF8 23196367 1207 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWERQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRER 2yme I 2.4 BS02 CWB I 1 W145 C188 Y193 W145 C188 Y193 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=343uM Q8WSF8 23196367 1207 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWERQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRER 2yme J 2.4 BS01 CWB I 1 W53 R55 I116 W53 R55 I116 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=343uM Q8WSF8 23196367 1207 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWERQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRER 2yme J 2.4 BS02 CWB J 1 W145 C188 W145 C188 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=343uM Q8WSF8 23196367 1207 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWERQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRER