2yjf A 3.5 BS01 LAB A 1 L16 P32 Q59 D157 R183 T186 R206 E207 R210 L12 P28 Q41 D134 R160 T163 R183 E184 R187 3.6.4.- 0000287,0001725,0003785,0005509,0005515,0005523,0005524,0005737,0005856,0005865,0005884,0010628,0016787,0019904,0030027,0030041,0030175,0030240,0031013,0031432,0031941,0032036,0032432,0042802,0044297,0048306,0048741,0051017,0090131,0098723,0140660 IC50=8470nM P68135 21673315 1376 TTALVCDNGSGLVKAGFAGDDAPRAVFPSIVKDSYVGDEAQSKRKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF 2yjf A 3.5 BS02 ATP A 1 G13 S14 G15 L16 K18 G156 D157 E214 G302 M305 Y306 K336 G9 S10 G11 L12 K14 G133 D134 E191 G279 M282 Y283 K313 3.6.4.- 0000287,0001725,0003785,0005509,0005515,0005523,0005524,0005737,0005856,0005865,0005884,0010628,0016787,0019904,0030027,0030041,0030175,0030240,0031013,0031432,0031941,0032036,0032432,0042802,0044297,0048306,0048741,0051017,0090131,0098723,0140660 P68135 21673315 1377 TTALVCDNGSGLVKAGFAGDDAPRAVFPSIVKDSYVGDEAQSKRKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF 2yjf B 3.5 BS01 ATP B 1 G13 S14 G15 L16 K18 G156 D157 K213 E214 G302 Y306 G9 S10 G11 L12 K14 G116 D117 K173 E174 G262 Y266 3.6.4.- 0000287,0001725,0003785,0005509,0005515,0005523,0005524,0005737,0005856,0005865,0005884,0010628,0016787,0019904,0030027,0030041,0030175,0030240,0031013,0031432,0031941,0032036,0032432,0042802,0044297,0048306,0048741,0051017,0090131,0098723,0140660 P68135 21673315 1377 TTALVCDNGSGLVKAGFAGDDAPRAVFPYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF 2yjf C 3.5 BS01 LAB C 1 G15 L16 P32 D157 R183 T186 R206 E207 R210 G10 L11 P27 D125 R151 T154 R174 E175 R178 3.6.4.- 0000287,0001725,0003785,0005509,0005515,0005523,0005524,0005737,0005856,0005865,0005884,0010628,0016787,0019904,0030027,0030041,0030175,0030240,0031013,0031432,0031941,0032036,0032432,0042802,0044297,0048306,0048741,0051017,0090131,0098723,0140660 IC50=8470nM P68135 21673315 1376 TALVCDNGSGLVKAGFAGDDAPRAVFPSVGDEAQSKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF 2yjf C 3.5 BS02 ATP C 1 G13 S14 G15 L16 K18 G156 D157 K213 E214 G302 M305 Y306 K336 G8 S9 G10 L11 K13 G124 D125 K181 E182 G270 M273 Y274 K304 3.6.4.- 0000287,0001725,0003785,0005509,0005515,0005523,0005524,0005737,0005856,0005865,0005884,0010628,0016787,0019904,0030027,0030041,0030175,0030240,0031013,0031432,0031941,0032036,0032432,0042802,0044297,0048306,0048741,0051017,0090131,0098723,0140660 P68135 21673315 1377 TALVCDNGSGLVKAGFAGDDAPRAVFPSVGDEAQSKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF 2yjf D 3.5 BS01 ATP D 1 G13 S14 G15 L16 K18 G156 D157 K213 E214 G302 M305 Y306 G9 S10 G11 L12 K14 G131 D132 K188 E189 G272 M275 Y276 3.6.4.- 0000287,0001725,0003785,0005509,0005515,0005523,0005524,0005737,0005856,0005865,0005884,0010628,0016787,0019904,0030027,0030041,0030175,0030240,0031013,0031432,0031941,0032036,0032432,0042802,0044297,0048306,0048741,0051017,0090131,0098723,0140660 P68135 21673315 1377 TTALVCDNGSGLVKAGFAGDDAPRAVFPSIVDSYVGDEILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATALEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF 2yjf E 3.5 BS01 ATP E 1 G13 S14 G15 L16 K18 G156 D157 G302 M305 G8 S9 G10 L11 K13 G113 D114 G249 M252 3.6.4.- 0000287,0001725,0003785,0005509,0005515,0005523,0005524,0005737,0005856,0005865,0005884,0010628,0016787,0019904,0030027,0030041,0030175,0030240,0031013,0031432,0031941,0032036,0032432,0042802,0044297,0048306,0048741,0051017,0090131,0098723,0140660 P68135 21673315 1377 TALVCDNGSGLVKAGFAGDDAPRAVFPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKTIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVH