2yir A 2.1 BS01 YIR A 1 L226 V234 K249 I251 E273 L301 L303 M304 G307 L354 T367 D368 L17 V25 K40 I42 E50 L78 L80 M81 G84 L131 T144 D145 D347 K349 N352 D368 T387 D124 K126 N129 D145 T164 2.7.11.1 0004672,0005524,0006468 ic50=0.17nM -logKd/Ki=9.77, IC50=0.17nM O96017 21907711 600 SVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKLNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEENESTALP