2yac A 2.2 BS01 937 A 1 R57 L59 G60 C67 A80 K82 L130 C133 R134 R136 S137 E140 F183 D194 A328 R19 L21 G22 C29 A42 K44 L92 C95 R96 R98 S99 E102 F145 D156 A290 D176 K178 G180 N181 D194 T214 D138 K140 G142 N143 D156 T176 2.7.11.21 0004672,0005524,0006468 ic50=0.002uM -logKd/Ki=8.70, IC50=0.002uM IC50=3nM P53350 21470862 501 EIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIA 2yac A 2.2 BS02 ZN A 1 H93 C212 H55 C174 D176 K178 G180 N181 D194 T214 D138 K140 G142 N143 D156 T176 2.7.11.21 0004672,0005524,0006468 P53350 21470862 502 EIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIA