2xyn A 2.81 BS01 VX6 A 1 L294 Y299 V302 A315 T361 E362 Y363 M364 P365 Y366 G367 L416 D427 L15 Y20 V23 A36 T80 E81 Y82 M83 P84 Y85 G86 L135 D146 D409 A411 R413 N414 D427 P448 D128 A130 R132 N133 D146 P167 2.7.10.2 0004672,0004713,0005524,0006468 -logKd/Ki=8.40, Kd=4nM Kd=4nM P42684 21417343 547 KWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHD 2xyn B 2.81 BS01 VX6 B 1 L294 Y299 M336 E362 Y363 M364 P365 G367 L416 D427 L15 Y20 M55 E81 Y82 M83 P84 G86 L135 D146 D409 A411 R413 N414 D427 P448 D128 A130 R132 N133 D146 P167 2.7.10.2 0004672,0004713,0005524,0006468 Kd=4nM P42684 21417343 547 KWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHD 2xyn B 2.81 BS02 VX6 B 2 T352 L353 P355 F357 T71 L72 P74 F76 D409 A411 R413 N414 D427 P448 D128 A130 R132 N133 D146 P167 2.7.10.2 0004672,0004713,0005524,0006468 Kd=4nM P42684 21417343 548 KWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHD 2xyn B 2.81 BS03 VX6 B 3 D437 T438 Y459 T461 S463 K465 P526 A527 D156 T157 Y178 T180 S182 K184 P245 A246 D409 A411 R413 N414 D427 P448 D128 A130 R132 N133 D146 P167 2.7.10.2 0004672,0004713,0005524,0006468 Kd=4nM P42684 21417343 549 KWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHD 2xyn C 2.81 BS01 VX6 C 1 L294 Y299 V302 A315 K317 T361 Y363 M364 P365 Y366 G367 L416 D427 L14 Y19 V22 A35 K37 T79 Y81 M82 P83 Y84 G85 L134 D145 D409 A411 R413 N414 D427 P448 D127 A129 R131 N132 D145 P166 2.7.10.2 0004672,0004713,0005524,0006468 Kd=4nM P42684 21417343 547 WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFH 2xyn C 2.81 BS02 VX6 C 2 L353 P355 L71 P73 D409 A411 R413 N414 D427 P448 D127 A129 R131 N132 D145 P166 2.7.10.2 0004672,0004713,0005524,0006468 Kd=4nM P42684 21417343 548 WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFH 2xyn C 2.81 BS03 VX6 C 3 K446 I449 S492 Y495 K164 I167 S210 Y213 D409 A411 R413 N414 D427 P448 D127 A129 R131 N132 D145 P166 2.7.10.2 0004672,0004713,0005524,0006468 Kd=4nM P42684 21417343 549 WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFH