2wx2 A 2.27 BS01 HEM A 1 L127 L134 A291 G292 T295 L356 V359 R361 G414 F415 H420 C422 I423 G424 L102 L109 A255 G256 T259 L320 V323 R325 G378 F379 H384 C386 I387 G388 S296 S260 1.14.14.154 0004497,0005506,0008398,0016020,0016126,0016705,0020037,0046872 Q7Z1V1 20386598 1450 TTRPTDPPVYPVTVPFLGHIVQFGKNPLEFMQRCKRDLKSGVFTISIGGQRVTIVGDPHEHSRFFSPRNEILSPREVYTIMTPVFGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQHEVRKFMAENWKEDEGVINLLEDCGAMIINTACQCLFGEDLRKRLNARHFAQLLSKMESSLIPAAVFMPWLLRLPLPRCREARAELQKILGEIIVAREKESDLLGGLLKAVYRDGTRMSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMHPKNKKWLDKLHKEIDEFPAQLNYDNVMDEMPFAERCVRESIRRDPPLLMVMRMVKAEVKVGSYVVPKGDIIACSPLLSHHDEEAFPNPRLWDPERDEKVDGAFIGFGAGVHKCIGQKFALLQVKTILATAFREYDFQLLRDEVPDPDYHTMVVGPTLNQCLVKYTRKK 2wx2 A 2.27 BS02 TPF A 1 M106 Y116 A291 L356 M81 Y91 A255 L320 S296 S260 1.14.14.154 0004497,0005506,0008398,0016020,0016126,0016705,0020037,0046872 IC50=880nM, Kd=2.3e+2nM Q7Z1V1 20386598 1460 TTRPTDPPVYPVTVPFLGHIVQFGKNPLEFMQRCKRDLKSGVFTISIGGQRVTIVGDPHEHSRFFSPRNEILSPREVYTIMTPVFGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQHEVRKFMAENWKEDEGVINLLEDCGAMIINTACQCLFGEDLRKRLNARHFAQLLSKMESSLIPAAVFMPWLLRLPLPRCREARAELQKILGEIIVAREKESDLLGGLLKAVYRDGTRMSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMHPKNKKWLDKLHKEIDEFPAQLNYDNVMDEMPFAERCVRESIRRDPPLLMVMRMVKAEVKVGSYVVPKGDIIACSPLLSHHDEEAFPNPRLWDPERDEKVDGAFIGFGAGVHKCIGQKFALLQVKTILATAFREYDFQLLRDEVPDPDYHTMVVGPTLNQCLVKYTRKK 2wx2 B 2.27 BS01 HEM B 1 Y116 L127 A291 T295 L356 V359 R361 G414 F415 H420 C422 I423 G424 Y89 L100 A250 T254 L315 V318 R320 G373 F374 H379 C381 I382 G383 S296 S255 1.14.14.154 0004497,0005506,0008398,0016020,0016126,0016705,0020037,0046872 Q7Z1V1 20386598 1450 RPTDPPVYPVTVPFLGHIVQFGKNPLEFMQRCKRDLKSGVFTISIGGQRVTIVGDPHEHSRFFSPRNEILSPREVYTIMTPVFGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQHEVRKFMAENWKEDEGVINLLEDCGAMIINTACQCLFGEDLRKRLNARHFAQLLSLIPAAVFMPWLLRLPLPQSARCREARAELQKILGEIIVAREKSDLLGGLLKAVYRDGTRMSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMHPKNKKWLDKLHKEIDEFPAQLNYDNVMDEMPFAERCVRESIRRDPPLLMVMRMVKAEVKVGSYVVPKGDIIACSPLLSHHDEEAFPNPRLWDPERDEKVDGAFIGFGAGVHKCIGQKFALLQVKTILATAFREYDFQLLRDEVPDPDYHTMVVGPTLNQCLVKYTRKKKLPSHHHH 2wx2 B 2.27 BS02 TPF B 1 Y103 F110 A291 L356 Y76 F83 A250 L315 S296 S255 1.14.14.154 0004497,0005506,0008398,0016020,0016126,0016705,0020037,0046872 IC50=880nM, Kd=2.3e+2nM Q7Z1V1 20386598 1460 RPTDPPVYPVTVPFLGHIVQFGKNPLEFMQRCKRDLKSGVFTISIGGQRVTIVGDPHEHSRFFSPRNEILSPREVYTIMTPVFGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQHEVRKFMAENWKEDEGVINLLEDCGAMIINTACQCLFGEDLRKRLNARHFAQLLSLIPAAVFMPWLLRLPLPQSARCREARAELQKILGEIIVAREKSDLLGGLLKAVYRDGTRMSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMHPKNKKWLDKLHKEIDEFPAQLNYDNVMDEMPFAERCVRESIRRDPPLLMVMRMVKAEVKVGSYVVPKGDIIACSPLLSHHDEEAFPNPRLWDPERDEKVDGAFIGFGAGVHKCIGQKFALLQVKTILATAFREYDFQLLRDEVPDPDYHTMVVGPTLNQCLVKYTRKKKLPSHHHH