2wpf A 1.9 BS01 FAD A 1 I10 G11 G13 S14 V34 D35 V36 A46 A47 G50 T51 C52 G56 C57 K60 W126 G127 T160 G161 F198 I199 R287 R290 G326 D327 M333 L334 T335 I12 G13 G15 S16 V36 D37 V38 A48 A49 G52 T53 C54 G58 C59 K62 W128 G129 T162 G163 F200 I201 R289 R292 G328 D329 M335 L336 T337 S14 L48 C52 C57 K60 G85 S86 F198 E202 I339 G459 H461 E466 E485 K486 S16 L50 C54 C59 K62 G87 S88 F200 E204 I341 G461 H463 E468 E487 K488 1.8.1.12 0000166,0004791,0005654,0005737,0015036,0015042,0016491,0016668,0020015,0045454,0046872,0050660,0097014,0098869 Q389T8 21851087 998 SHMSKAFDLVVIGAGSGGLEAGWNAATLYGKRVAVVDVQTSHGPPFYAALGGTCVNVGCVPKKLMVTGAQYMDHLRESAGFGWEFDGSSVKANWKKLIAAKNEAVLDINKSYEGMFNDTEGLDFFLGWGSLESKNVVVVRETADPKSAVKERLQADHILLATGSWPQMPAIPGIEHCISSNEAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPPGGKVTLCYRNNLILRGFDETIREEVTKQLTANGIEIMTNENPAKVSLNTDGSKHVTFESGKTLDVDVVMMAIGRIPRTNDLQLGNVGVKLTPKGGVQVDEFSRTNVPNIYAIGDITDRLMLTPVAINEGAALVDTVFGNKPRKTDHTRVASAVFSIPPIGTCGLIEEVAAKEFEKVAVYMSSFTPLMHNISGSKYKKFVAKIVTNHSDGTVLGVHLLGDGAPEIIQAVGVCLRLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYVKGEKMEKLP 2wpf A 1.9 BS02 WPF A 1 S14 L17 E18 W21 Y110 M113 F114 S16 L19 E20 W23 Y112 M115 F116 S14 L48 C52 C57 K60 G85 S86 F198 E202 I339 G459 H461 E466 E485 K486 S16 L50 C54 C59 K62 G87 S88 F200 E204 I341 G461 H463 E468 E487 K488 1.8.1.12 0000166,0004791,0005654,0005737,0015036,0015042,0016491,0016668,0020015,0045454,0046872,0050660,0097014,0098869 ic50=0.23uM Q389T8 21851087 1000 SHMSKAFDLVVIGAGSGGLEAGWNAATLYGKRVAVVDVQTSHGPPFYAALGGTCVNVGCVPKKLMVTGAQYMDHLRESAGFGWEFDGSSVKANWKKLIAAKNEAVLDINKSYEGMFNDTEGLDFFLGWGSLESKNVVVVRETADPKSAVKERLQADHILLATGSWPQMPAIPGIEHCISSNEAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPPGGKVTLCYRNNLILRGFDETIREEVTKQLTANGIEIMTNENPAKVSLNTDGSKHVTFESGKTLDVDVVMMAIGRIPRTNDLQLGNVGVKLTPKGGVQVDEFSRTNVPNIYAIGDITDRLMLTPVAINEGAALVDTVFGNKPRKTDHTRVASAVFSIPPIGTCGLIEEVAAKEFEKVAVYMSSFTPLMHNISGSKYKKFVAKIVTNHSDGTVLGVHLLGDGAPEIIQAVGVCLRLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYVKGEKMEKLP 2wpf B 1.9 BS01 FAD B 1 I10 G11 G13 S14 G15 V34 D35 V36 A46 G50 T51 C52 V55 G56 C57 K60 W126 G127 T160 G161 F198 R287 R290 G326 D327 M333 L334 T335 I9 G10 G12 S13 G14 V33 D34 V35 A45 G49 T50 C51 V54 G55 C56 K59 W125 G126 T159 G160 F197 R286 R289 G325 D326 M332 L333 T334 S14 L48 C52 C57 K60 G85 S86 F198 E202 I339 G459 H461 E466 E485 K486 S13 L47 C51 C56 K59 G84 S85 F197 E201 I338 G458 H460 E465 E484 K485 1.8.1.12 0000166,0004791,0005654,0005737,0015036,0015042,0016491,0016668,0020015,0045454,0046872,0050660,0097014,0098869 Q389T8 21851087 998 SKAFDLVVIGAGSGGLEAGWNAATLYGKRVAVVDVQTSHGPPFYAALGGTCVNVGCVPKKLMVTGAQYMDHLRESAGFGWEFDGSSVKANWKKLIAAKNEAVLDINKSYEGMFNDTEGLDFFLGWGSLESKNVVVVRETADPKSAVKERLQADHILLATGSWPQMPAIPGIEHCISSNEAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPPGGKVTLCYRNNLILRGFDETIREEVTKQLTANGIEIMTNENPAKVSLNTDGSKHVTFESGKTLDVDVVMMAIGRIPRTNDLQLGNVGVKLTPKGGVQVDEFSRTNVPNIYAIGDITDRLMLTPVAINEGAALVDTVFGNKPRKTDHTRVASAVFSIPPIGTCGLIEEVAAKEFEKVAVYMSSFTPLMHNISGSKYKKFVAKIVTNHSDGTVLGVHLLGDGAPEIIQAVGVCLRLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYVKGEKMEKLP 2wpf B 1.9 BS02 WPF B 1 S14 L17 E18 W21 Y110 M113 F114 I339 S13 L16 E17 W20 Y109 M112 F113 I338 S14 L48 C52 C57 K60 G85 S86 F198 E202 I339 G459 H461 E466 E485 K486 S13 L47 C51 C56 K59 G84 S85 F197 E201 I338 G458 H460 E465 E484 K485 1.8.1.12 0000166,0004791,0005654,0005737,0015036,0015042,0016491,0016668,0020015,0045454,0046872,0050660,0097014,0098869 ic50=0.23uM Q389T8 21851087 1000 SKAFDLVVIGAGSGGLEAGWNAATLYGKRVAVVDVQTSHGPPFYAALGGTCVNVGCVPKKLMVTGAQYMDHLRESAGFGWEFDGSSVKANWKKLIAAKNEAVLDINKSYEGMFNDTEGLDFFLGWGSLESKNVVVVRETADPKSAVKERLQADHILLATGSWPQMPAIPGIEHCISSNEAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPPGGKVTLCYRNNLILRGFDETIREEVTKQLTANGIEIMTNENPAKVSLNTDGSKHVTFESGKTLDVDVVMMAIGRIPRTNDLQLGNVGVKLTPKGGVQVDEFSRTNVPNIYAIGDITDRLMLTPVAINEGAALVDTVFGNKPRKTDHTRVASAVFSIPPIGTCGLIEEVAAKEFEKVAVYMSSFTPLMHNISGSKYKKFVAKIVTNHSDGTVLGVHLLGDGAPEIIQAVGVCLRLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYVKGEKMEKLP 2wpf C 1.9 BS01 FAD C 1 I10 G11 G13 S14 G15 V34 D35 V36 A46 A47 G50 T51 C52 G56 C57 K60 W126 G127 T160 G161 I199 R287 R290 G326 D327 M333 L334 T335 I8 G9 G11 S12 G13 V32 D33 V34 A44 A45 G48 T49 C50 G54 C55 K58 W124 G125 T158 G159 I197 R285 R288 G324 D325 M331 L332 T333 S14 L48 C52 C57 K60 G85 S86 F198 E202 I339 G459 H461 E466 E485 K486 S12 L46 C50 C55 K58 G83 S84 F196 E200 I337 G457 H459 E464 E483 K484 1.8.1.12 0000166,0004791,0005654,0005737,0015036,0015042,0016491,0016668,0020015,0045454,0046872,0050660,0097014,0098869 Q389T8 21851087 998 KAFDLVVIGAGSGGLEAGWNAATLYGKRVAVVDVQTSHGPPFYAALGGTCVNVGCVPKKLMVTGAQYMDHLRESAGFGWEFDGSSVKANWKKLIAAKNEAVLDINKSYEGMFNDTEGLDFFLGWGSLESKNVVVVRETADPKSAVKERLQADHILLATGSWPQMPAIPGIEHCISSNEAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPPGGKVTLCYRNNLILRGFDETIREEVTKQLTANGIEIMTNENPAKVSLNTDGSKHVTFESGKTLDVDVVMMAIGRIPRTNDLQLGNVGVKLTPKGGVQVDEFSRTNVPNIYAIGDITDRLMLTPVAINEGAALVDTVFGNKPRKTDHTRVASAVFSIPPIGTCGLIEEVAAKEFEKVAVYMSSFTPLMHNISGSKYKKFVAKIVTNHSDGTVLGVHLLGDGAPEIIQAVGVCLRLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYVKGEKMEKLPD 2wpf C 1.9 BS02 WPF C 1 L17 E18 W21 Y110 M113 I339 L15 E16 W19 Y108 M111 I337 S14 L48 C52 C57 K60 G85 S86 F198 E202 I339 G459 H461 E466 E485 K486 S12 L46 C50 C55 K58 G83 S84 F196 E200 I337 G457 H459 E464 E483 K484 1.8.1.12 0000166,0004791,0005654,0005737,0015036,0015042,0016491,0016668,0020015,0045454,0046872,0050660,0097014,0098869 ic50=0.23uM Q389T8 21851087 1000 KAFDLVVIGAGSGGLEAGWNAATLYGKRVAVVDVQTSHGPPFYAALGGTCVNVGCVPKKLMVTGAQYMDHLRESAGFGWEFDGSSVKANWKKLIAAKNEAVLDINKSYEGMFNDTEGLDFFLGWGSLESKNVVVVRETADPKSAVKERLQADHILLATGSWPQMPAIPGIEHCISSNEAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPPGGKVTLCYRNNLILRGFDETIREEVTKQLTANGIEIMTNENPAKVSLNTDGSKHVTFESGKTLDVDVVMMAIGRIPRTNDLQLGNVGVKLTPKGGVQVDEFSRTNVPNIYAIGDITDRLMLTPVAINEGAALVDTVFGNKPRKTDHTRVASAVFSIPPIGTCGLIEEVAAKEFEKVAVYMSSFTPLMHNISGSKYKKFVAKIVTNHSDGTVLGVHLLGDGAPEIIQAVGVCLRLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYVKGEKMEKLPD 2wpf D 1.9 BS01 FAD D 1 I10 G11 G13 S14 G15 V34 D35 V36 A46 A47 G50 T51 C52 G56 C57 K60 G127 T160 G161 F198 I199 R287 R290 G326 D327 M333 L334 T335 A338 I13 G14 G16 S17 G18 V37 D38 V39 A49 A50 G53 T54 C55 G59 C60 K63 G130 T163 G164 F201 I202 R290 R293 G329 D330 M336 L337 T338 A341 S14 L48 C52 C57 K60 G85 S86 F198 E202 I339 G459 H461 E466 E485 K486 S17 L51 C55 C60 K63 G88 S89 F201 E205 I342 G462 H464 E469 E488 K489 1.8.1.12 0000166,0004791,0005654,0005737,0015036,0015042,0016491,0016668,0020015,0045454,0046872,0050660,0097014,0098869 Q389T8 21851087 998 GSHMSKAFDLVVIGAGSGGLEAGWNAATLYGKRVAVVDVQTSHGPPFYAALGGTCVNVGCVPKKLMVTGAQYMDHLRESAGFGWEFDGSSVKANWKKLIAAKNEAVLDINKSYEGMFNDTEGLDFFLGWGSLESKNVVVVRETADPKSAVKERLQADHILLATGSWPQMPAIPGIEHCISSNEAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPPGGKVTLCYRNNLILRGFDETIREEVTKQLTANGIEIMTNENPAKVSLNTDGSKHVTFESGKTLDVDVVMMAIGRIPRTNDLQLGNVGVKLTPKGGVQVDEFSRTNVPNIYAIGDITDRLMLTPVAINEGAALVDTVFGNKPRKTDHTRVASAVFSIPPIGTCGLIEEVAAKEFEKVAVYMSSFTPLMHNISGSKYKKFVAKIVTNHSDGTVLGVHLLGDGAPEIIQAVGVCLRLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYVKGEKMEKLP 2wpf D 1.9 BS02 WPF D 1 S14 L17 E18 W21 Y110 M113 F114 S17 L20 E21 W24 Y113 M116 F117 S14 L48 C52 C57 K60 G85 S86 F198 E202 I339 G459 H461 E466 E485 K486 S17 L51 C55 C60 K63 G88 S89 F201 E205 I342 G462 H464 E469 E488 K489 1.8.1.12 0000166,0004791,0005654,0005737,0015036,0015042,0016491,0016668,0020015,0045454,0046872,0050660,0097014,0098869 ic50=0.23uM Q389T8 21851087 1000 GSHMSKAFDLVVIGAGSGGLEAGWNAATLYGKRVAVVDVQTSHGPPFYAALGGTCVNVGCVPKKLMVTGAQYMDHLRESAGFGWEFDGSSVKANWKKLIAAKNEAVLDINKSYEGMFNDTEGLDFFLGWGSLESKNVVVVRETADPKSAVKERLQADHILLATGSWPQMPAIPGIEHCISSNEAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPPGGKVTLCYRNNLILRGFDETIREEVTKQLTANGIEIMTNENPAKVSLNTDGSKHVTFESGKTLDVDVVMMAIGRIPRTNDLQLGNVGVKLTPKGGVQVDEFSRTNVPNIYAIGDITDRLMLTPVAINEGAALVDTVFGNKPRKTDHTRVASAVFSIPPIGTCGLIEEVAAKEFEKVAVYMSSFTPLMHNISGSKYKKFVAKIVTNHSDGTVLGVHLLGDGAPEIIQAVGVCLRLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYVKGEKMEKLP