2wo9 A 1.7 BS01 ZN A 1 H218 H222 H228 H113 H117 H123 H218 E219 H222 H228 H113 E114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 19703773 1268 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYGDPKE 2wo9 A 1.7 BS02 ZN A 2 H168 D170 H183 H196 H63 D65 H78 H91 H218 E219 H222 H228 H113 E114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 19703773 1269 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYGDPKE 2wo9 A 1.7 BS03 CA A 1 D175 G176 G178 I180 D198 E201 D70 G71 G73 I75 D93 E96 H218 E219 H222 H228 H113 E114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 19703773 1270 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYGDPKE 2wo9 A 1.7 BS04 068 A 1 I180 L181 A182 H218 E219 H222 H228 V235 T239 Y240 F248 I75 L76 A77 H113 E114 H117 H123 V130 T134 Y135 F143 H218 E219 H222 H228 H113 E114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 ic50=0.062uM -logKd/Ki=7.21, IC50=62nM IC50=62nM P39900 19703773 1271 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYGDPKE 2wo9 B 1.7 BS01 023 B 1 G179 I180 L181 L214 T215 H218 E219 H222 H228 P238 T239 Y240 K241 G75 I76 L77 L110 T111 H114 E115 H118 H124 P134 T135 Y136 K137 H218 E219 H222 H228 H114 E115 H118 H124 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 19703773 1267 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYGDPK 2wo9 B 1.7 BS02 ZN B 1 H218 H222 H228 H114 H118 H124 H218 E219 H222 H228 H114 E115 H118 H124 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 19703773 1268 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYGDPK 2wo9 B 1.7 BS03 ZN B 2 H168 D170 H183 H196 H64 D66 H79 H92 H218 E219 H222 H228 H114 E115 H118 H124 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 19703773 1269 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYGDPK 2wo9 B 1.7 BS04 CA B 1 D175 G176 G178 I180 D198 E201 D71 G72 G74 I76 D94 E97 H218 E219 H222 H228 H114 E115 H118 H124 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 19703773 1270 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYGDPK 2wo9 B 1.7 BS05 CA B 2 D158 G190 I191 G192 D194 D54 G86 I87 G88 D90 H218 E219 H222 H228 H114 E115 H118 H124 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 19703773 1271 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYGDPK 2wo9 B 1.7 BS06 CA B 3 D124 E199 E201 D20 E95 E97 H218 E219 H222 H228 H114 E115 H118 H124 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 19703773 1272 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYGDPK 2wo9 C 1.7 BS01 ZN C 1 H218 H222 H228 H114 H118 H124 H218 E219 H222 H228 H114 E115 H118 H124 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 19703773 1269 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYGDPKEN 2wo9 C 1.7 BS02 ZN C 2 H168 D170 H183 H196 H64 D66 H79 H92 H218 E219 H222 H228 H114 E115 H118 H124 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 19703773 1270 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYGDPKEN 2wo9 C 1.7 BS03 CA C 1 D175 G176 G178 I180 D198 E201 D71 G72 G74 I76 D94 E97 H218 E219 H222 H228 H114 E115 H118 H124 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 19703773 1271 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYGDPKEN 2wo9 C 1.7 BS04 068 C 1 L181 A182 T215 H218 E219 H222 H228 K233 V235 T239 Y240 L77 A78 T111 H114 E115 H118 H124 K129 V131 T135 Y136 H218 E219 H222 H228 H114 E115 H118 H124 3.4.24.65 0004222,0006508,0008237,0008270,0031012 ic50=0.062uM IC50=62nM P39900 19703773 1272 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYGDPKEN 2wo9 D 1.7 BS01 023 D 1 G179 I180 L181 L214 T215 H218 E219 H222 H228 P238 T239 Y240 K241 G74 I75 L76 L109 T110 H113 E114 H117 H123 P133 T134 Y135 K136 H218 E219 H222 H228 H113 E114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 19703773 1266 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYGDP 2wo9 D 1.7 BS02 ZN D 1 H218 H222 H228 H113 H117 H123 H218 E219 H222 H228 H113 E114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 19703773 1267 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYGDP 2wo9 D 1.7 BS03 ZN D 2 H168 D170 H183 H196 H63 D65 H78 H91 H218 E219 H222 H228 H113 E114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 19703773 1268 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYGDP 2wo9 D 1.7 BS04 CA D 1 D175 G176 G178 I180 D198 E201 D70 G71 G73 I75 D93 E96 H218 E219 H222 H228 H113 E114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 19703773 1269 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYGDP 2wo9 D 1.7 BS05 CA D 2 D124 E199 E201 D19 E94 E96 H218 E219 H222 H228 H113 E114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 19703773 1270 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYGDP