2wbg A 1.85 BS01 LGS A 1 Q20 H121 N165 E166 Y295 H298 W324 E351 W398 E405 W406 Q18 H119 N163 E164 Y293 H296 W322 E349 W396 E403 W404 R77 H121 E166 V169 N293 Y295 E351 R75 H119 E164 V167 N291 Y293 E349 3.2.1.21 0004553,0005975,0008422,0016798,0030245,0102483 Ki=35.2uM -logKd/Ki=4.45, Ki=35.2uM Q08638 19532990 1446 VKKFPEGFLWGVATASYQIEGSPLADGAGMSIWHTFSHTPGNVKNGDTGDVACDHYNRWKEDIEIIEKLGVKAYRFSISWPRILPEGTGRVNQKGLDFYNRIIDTLLEKGITPFVTIYHWDLPFALQLKGGWANREIADWFAEYSRVLFENFGDRVKNWITLNEPWVVAIVGHLYGVHAPGMRDIYVAFRAVHNLLRAHARAVKVFRETVKDGKIGIVFNNGYFEPASEKEEDIRAVRFMHQFNNYPLFLNPIYRGDYPELVLEFAREYLPENYKDDMSEIQEKIDFVGLNYYSGHLVKFDPDAPAKVSFVERDLPKTAMGWEIVPEGIYWILKKVKEEYNPPEVYITENGAAFDDVVSEDGRVHDQNRIDYLKAHIGQAWKAIQEGVPLKGYFVWSLLDNFEWAEGYSKRFGIVYVDYSTQKRIVKDSGYWYSNVVKNNGLE 2wbg B 1.85 BS01 LGS B 1 Q20 H121 N165 E166 Y295 H298 W324 E351 W398 E405 W406 Q18 H119 N163 E164 Y293 H296 W322 E349 W396 E403 W404 R77 H121 E166 V169 N293 Y295 E351 R75 H119 E164 V167 N291 Y293 E349 3.2.1.21 0004553,0005975,0008422,0016798,0030245,0102483 Ki=35.2uM Q08638 19532990 1446 VKKFPEGFLWGVATASYQIEGSPLADGAGMSIWHTFSHTPGNVKNGDTGDVACDHYNRWKEDIEIIEKLGVKAYRFSISWPRILPEGTGRVNQKGLDFYNRIIDTLLEKGITPFVTIYHWDLPFALQLKGGWANREIADWFAEYSRVLFENFGDRVKNWITLNEPWVVAIVGHLYGVHAPGMRDIYVAFRAVHNLLRAHARAVKVFRETVKDGKIGIVFNNGYFEPASEKEEDIRAVRFMHQFNNYPLFLNPIYRGDYPELVLEFAREYLPENYKDDMSEIQEKIDFVGLNYYSGHLVKFDPDAPAKVSFVERDLPKTAMGWEIVPEGIYWILKKVKEEYNPPEVYITENGAAFDDVVSEDGRVHDQNRIDYLKAHIGQAWKAIQEGVPLKGYFVWSLLDNFEWAEGYSKRFGIVYVDYSTQKRIVKDSGYWYSNVVKNNGLE 2wbg C 1.85 BS01 LGS C 1 Q20 H121 N165 E166 Y295 W324 E351 W398 E405 W406 Q18 H119 N163 E164 Y293 W322 E349 W396 E403 W404 R77 H121 E166 V169 N293 Y295 E351 R75 H119 E164 V167 N291 Y293 E349 3.2.1.21 0004553,0005975,0008422,0016798,0030245,0102483 Ki=35.2uM Q08638 19532990 1446 VKKFPEGFLWGVATASYQIEGSPLADGAGMSIWHTFSHTPGNVKNGDTGDVACDHYNRWKEDIEIIEKLGVKAYRFSISWPRILPEGTGRVNQKGLDFYNRIIDTLLEKGITPFVTIYHWDLPFALQLKGGWANREIADWFAEYSRVLFENFGDRVKNWITLNEPWVVAIVGHLYGVHAPGMRDIYVAFRAVHNLLRAHARAVKVFRETVKDGKIGIVFNNGYFEPASEKEEDIRAVRFMHQFNNYPLFLNPIYRGDYPELVLEFAREYLPENYKDDMSEIQEKIDFVGLNYYSGHLVKFDPDAPAKVSFVERDLPKTAMGWEIVPEGIYWILKKVKEEYNPPEVYITENGAAFDDVVSEDGRVHDQNRIDYLKAHIGQAWKAIQEGVPLKGYFVWSLLDNFEWAEGYSKRFGIVYVDYSTQKRIVKDSGYWYSNVVKNNGLE 2wbg D 1.85 BS01 LGS D 1 Q20 H121 N165 E166 Y295 W324 E351 W398 E405 Q18 H119 N163 E164 Y293 W322 E349 W396 E403 R77 H121 E166 V169 N293 Y295 E351 R75 H119 E164 V167 N291 Y293 E349 3.2.1.21 0004553,0005975,0008422,0016798,0030245,0102483 Ki=35.2uM Q08638 19532990 1446 VKKFPEGFLWGVATASYQIEGSPLADGAGMSIWHTFSHTPGNVKNGDTGDVACDHYNRWKEDIEIIEKLGVKAYRFSISWPRILPEGTGRVNQKGLDFYNRIIDTLLEKGITPFVTIYHWDLPFALQLKGGWANREIADWFAEYSRVLFENFGDRVKNWITLNEPWVVAIVGHLYGVHAPGMRDIYVAFRAVHNLLRAHARAVKVFRETVKDGKIGIVFNNGYFEPASEKEEDIRAVRFMHQFNNYPLFLNPIYRGDYPELVLEFAREYLPENYKDDMSEIQEKIDFVGLNYYSGHLVKFDPDAPAKVSFVERDLPKTAMGWEIVPEGIYWILKKVKEEYNPPEVYITENGAAFDDVVSEDGRVHDQNRIDYLKAHIGQAWKAIQEGVPLKGYFVWSLLDNFEWAEGYSKRFGIVYVDYSTQKRIVKDSGYWYSNVVKNNGLE