2w0d A 2.0 BS01 ZN A 1 H218 H222 H228 H113 H117 H123 H218 A219 H222 H228 H113 A114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 19239231 1264 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHAIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 2w0d A 2.0 BS02 ZN A 2 H168 D170 H183 H196 H63 D65 H78 H91 H218 A219 H222 H228 H113 A114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 19239231 1265 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHAIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 2w0d A 2.0 BS03 CA A 1 D175 G176 G178 I180 D198 E201 D70 G71 G73 I75 D93 E96 H218 A219 H222 H228 H113 A114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 19239231 1266 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHAIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 2w0d A 2.0 BS04 CA A 2 D124 E199 E201 D19 E94 E96 H218 A219 H222 H228 H113 A114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 19239231 1267 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHAIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 2w0d A 2.0 BS05 CA A 3 D158 G190 G192 D194 D53 G85 G87 D89 H218 A219 H222 H228 H113 A114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 19239231 1268 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHAIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 2w0d A 2.0 BS06 CGS A 1 I180 L181 A182 H218 H222 H228 P238 Y240 I75 L76 A77 H113 H117 H123 P133 Y135 H218 A219 H222 H228 H113 A114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 ic50~2nM -logKd/Ki=8.70, IC50=2.0nM P39900 19239231 1273 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHAIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 2w0d A 2.0 BS07 CGS C 1 G179 I180 G74 I75 H218 A219 H222 H228 H113 A114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 ic50~2nM -logKd/Ki=8.70, IC50=2.0nM P39900 19239231 1273 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHAIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 2w0d B 2.0 BS01 ZN B 1 H218 H222 H228 H113 H117 H123 H218 A219 H222 H228 H113 A114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 19239231 1264 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHAIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 2w0d B 2.0 BS02 ZN B 2 H168 D170 H183 H196 H63 D65 H78 H91 H218 A219 H222 H228 H113 A114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 19239231 1265 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHAIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 2w0d B 2.0 BS03 CA B 1 D175 G176 G178 I180 D198 E201 D70 G71 G73 I75 D93 E96 H218 A219 H222 H228 H113 A114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 19239231 1266 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHAIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 2w0d B 2.0 BS04 CA B 2 D124 E199 E201 D19 E94 E96 H218 A219 H222 H228 H113 A114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 19239231 1267 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHAIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 2w0d B 2.0 BS05 CA B 3 D158 G190 G192 D194 D53 G85 G87 D89 H218 A219 H222 H228 H113 A114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 19239231 1268 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHAIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 2w0d B 2.0 BS06 CGS B 1 I180 L181 A182 H218 H222 H228 P238 I75 L76 A77 H113 H117 H123 P133 H218 A219 H222 H228 H113 A114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 ic50~2nM P39900 19239231 1269 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHAIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 2w0d C 2.0 BS01 ZN C 1 H218 H222 H228 H114 H118 H124 H218 A219 H222 H228 H114 A115 H118 H124 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 19239231 1264 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHAIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 2w0d C 2.0 BS02 ZN C 2 H168 D170 H183 H196 H64 D66 H79 H92 H218 A219 H222 H228 H114 A115 H118 H124 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 19239231 1265 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHAIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 2w0d C 2.0 BS03 CA C 1 D175 G176 G178 I180 D198 E201 D71 G72 G74 I76 D94 E97 H218 A219 H222 H228 H114 A115 H118 H124 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 19239231 1266 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHAIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 2w0d C 2.0 BS04 CA C 2 D124 E199 E201 D20 E95 E97 H218 A219 H222 H228 H114 A115 H118 H124 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 19239231 1267 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHAIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 2w0d C 2.0 BS05 CA C 3 D158 G190 G192 D194 D54 G86 G88 D90 H218 A219 H222 H228 H114 A115 H118 H124 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 19239231 1268 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHAIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 2w0d C 2.0 BS06 CGS C 1 I180 A182 H218 H222 H228 P238 Y240 I76 A78 H114 H118 H124 P134 Y136 H218 A219 H222 H228 H114 A115 H118 H124 3.4.24.65 0004222,0006508,0008237,0008270,0031012 ic50~2nM P39900 19239231 1273 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHAIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 2w0d D 2.0 BS01 ZN D 1 H218 H222 H228 H114 H118 H124 H218 A219 H222 H228 H114 A115 H118 H124 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 19239231 1264 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHAIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 2w0d D 2.0 BS02 ZN D 2 H168 D170 H183 H196 H64 D66 H79 H92 H218 A219 H222 H228 H114 A115 H118 H124 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 19239231 1265 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHAIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 2w0d D 2.0 BS03 CA D 1 D175 G176 G178 I180 D198 E201 D71 G72 G74 I76 D94 E97 H218 A219 H222 H228 H114 A115 H118 H124 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 19239231 1266 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHAIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 2w0d D 2.0 BS04 CA D 2 D124 E199 E201 D20 E95 E97 H218 A219 H222 H228 H114 A115 H118 H124 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 19239231 1267 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHAIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 2w0d D 2.0 BS05 CA D 3 D158 G190 G192 D194 D54 G86 G88 D90 H218 A219 H222 H228 H114 A115 H118 H124 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 19239231 1268 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHAIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 2w0d D 2.0 BS06 CGS D 1 I180 L181 A182 T215 H218 H222 H228 P238 Y240 I76 L77 A78 T111 H114 H118 H124 P134 Y136 H218 A219 H222 H228 H114 A115 H118 H124 3.4.24.65 0004222,0006508,0008237,0008270,0031012 ic50~2nM P39900 19239231 1273 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHAIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG