2vnt A 2.2 BS01 QGG A 1 D201 S202 Q204 S207 V225 W227 G228 R229 G230 C231 D201 S202 Q204 S207 V225 W227 G228 R229 G230 C231 H55 D106 Q204 G205 D206 S207 G208 H55 D106 Q204 G205 D206 S207 G208 3.4.21.73 0004252,0006508 Ki=9.9nM -logKd/Ki=8.00, Ki=9.9nM Ki=9.9nM P00749 17447747 1258 KFQCGQKTLIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLMSPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEE 2vnt B 2.2 BS01 QGG B 1 D201 S202 C203 Q204 S207 V225 W227 G228 R229 G230 C231 D202 S203 C204 Q205 S208 V226 W228 G229 R230 G231 C232 H55 D106 Q204 G205 D206 S207 G208 H56 D107 Q205 G206 D207 S208 G209 3.4.21.73 0004252,0006508 Ki=9.9nM Ki=9.9nM P00749 17447747 1258 LKFQCGQKTLIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLMSPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEE 2vnt C 2.2 BS01 QGG C 1 D201 S202 C203 Q204 S207 V225 W227 G228 R229 G230 C231 D202 S203 C204 Q205 S208 V226 W228 G229 R230 G231 C232 H55 D106 Q204 G205 D206 S207 G208 H56 D107 Q205 G206 D207 S208 G209 3.4.21.73 0004252,0006508 Ki=9.9nM Ki=9.9nM P00749 17447747 1258 FQCGQKTLRPIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLMSPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEE 2vnt D 2.2 BS01 QGG D 1 D201 S202 C203 Q204 S207 V225 W227 G228 R229 G230 G238 D202 S203 C204 Q205 S208 V226 W228 G229 R230 G231 G239 H55 D106 Q204 G205 D206 S207 G208 H56 D107 Q205 G206 D207 S208 G209 3.4.21.73 0004252,0006508 Ki=9.9nM Ki=9.9nM P00749 17447747 1258 LKFQCGQKTLIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLMSPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEE 2vnt E 2.2 BS01 QGG E 1 D201 S202 Q204 S207 V225 W227 G228 R229 G230 C231 G238 D202 S203 Q205 S208 V226 W228 G229 R230 G231 C232 G239 H55 D106 Q204 G205 D206 S207 G208 H56 D107 Q205 G206 D207 S208 G209 3.4.21.73 0004252,0006508 Ki=9.9nM Ki=9.9nM P00749 17447747 1258 LKFQCGQKTLIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLMSPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEE 2vnt F 2.2 BS01 QGG A 1 S252 E257 S251 E256 H55 D106 Q204 G205 D206 S207 G208 H54 D105 Q203 G204 D205 S206 G207 3.4.21.73 0004252,0006508 Ki=9.9nM Ki=9.9nM P00749 17447747 1258 CGQKTLRPIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLMSPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEE 2vnt F 2.2 BS02 QGG F 1 D201 S202 Q204 S207 W227 G228 R229 G230 C231 D200 S201 Q203 S206 W226 G227 R228 G229 C230 H55 D106 Q204 G205 D206 S207 G208 H54 D105 Q203 G204 D205 S206 G207 3.4.21.73 0004252,0006508 Ki=9.9nM Ki=9.9nM P00749 17447747 1258 CGQKTLRPIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLMSPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEE