2vnp A 2.19 BS01 MN A 1 H25 H32 H69 E114 E116 H22 H29 H66 E111 E113 H25 H32 C67 H69 E87 Y104 E114 E116 W161 H22 H29 C64 H66 E84 Y101 E111 E113 W158 5.3.3.2 0000287,0003824,0004452,0005737,0006974,0008270,0008299,0016853,0046872,0050992 Q46822 18391416 1180 EHVILLNAQGVPTGTLEKYAAHTADTRLHLAFSSWLFNAKGQLLVTRRALSKKAWPGVWTNSVCGHPQLGESNEDAVIRRCRYELGVEITPPESIYPDFRYRATDPSGIVENEVCPVFAARTTSALQINDDEVMDYQWCDLADVLHGIDATPWAFSPWMVMQATNREARKRLSAFT 2vnp A 2.19 BS02 MG A 1 C67 E87 C64 E84 H25 H32 C67 H69 E87 Y104 E114 E116 W161 H22 H29 C64 H66 E84 Y101 E111 E113 W158 5.3.3.2 0000287,0003824,0004452,0005737,0006974,0008270,0008299,0016853,0046872,0050992 Q46822 18391416 1181 EHVILLNAQGVPTGTLEKYAAHTADTRLHLAFSSWLFNAKGQLLVTRRALSKKAWPGVWTNSVCGHPQLGESNEDAVIRRCRYELGVEITPPESIYPDFRYRATDPSGIVENEVCPVFAARTTSALQINDDEVMDYQWCDLADVLHGIDATPWAFSPWMVMQATNREARKRLSAFT 2vnp A 2.19 BS03 DED A 1 K21 R51 C67 G68 H69 R83 E114 E116 W161 K18 R48 C64 G65 H66 R80 E111 E113 W158 H25 H32 C67 H69 E87 Y104 E114 E116 W161 H22 H29 C64 H66 E84 Y101 E111 E113 W158 5.3.3.2 0000287,0003824,0004452,0005737,0006974,0008270,0008299,0016853,0046872,0050992 Ki=0.12nM -logKd/Ki=9.92, Ki=0.12nM Q46822 18391416 1182 EHVILLNAQGVPTGTLEKYAAHTADTRLHLAFSSWLFNAKGQLLVTRRALSKKAWPGVWTNSVCGHPQLGESNEDAVIRRCRYELGVEITPPESIYPDFRYRATDPSGIVENEVCPVFAARTTSALQINDDEVMDYQWCDLADVLHGIDATPWAFSPWMVMQATNREARKRLSAFT 2vnp B 2.19 BS01 MN B 1 H25 H32 H69 E114 E116 H22 H29 H66 E111 E113 H25 H32 C67 H69 E87 Y104 E114 E116 W161 H22 H29 C64 H66 E84 Y101 E111 E113 W158 5.3.3.2 0000287,0003824,0004452,0005737,0006974,0008270,0008299,0016853,0046872,0050992 Q46822 18391416 1184 EHVILLNAQGVPTGTLEKYAAHTADTRLHLAFSSWLFNAKGQLLVTRRALSKKAWPGVWTNSVCGHPQLGESNEDAVIRRCRYELGVEITPPESIYPDFRYRATDPSGIVENEVCPVFAARTTSALQINDDEVMDYQWCDLADVLHGIDATPWAFSPWMVMQATNREARKRLSAFTQLKL 2vnp B 2.19 BS02 MG B 1 C67 E87 C64 E84 H25 H32 C67 H69 E87 Y104 E114 E116 W161 H22 H29 C64 H66 E84 Y101 E111 E113 W158 5.3.3.2 0000287,0003824,0004452,0005737,0006974,0008270,0008299,0016853,0046872,0050992 Q46822 18391416 1185 EHVILLNAQGVPTGTLEKYAAHTADTRLHLAFSSWLFNAKGQLLVTRRALSKKAWPGVWTNSVCGHPQLGESNEDAVIRRCRYELGVEITPPESIYPDFRYRATDPSGIVENEVCPVFAARTTSALQINDDEVMDYQWCDLADVLHGIDATPWAFSPWMVMQATNREARKRLSAFTQLKL 2vnp B 2.19 BS03 DED B 1 K21 R51 K55 C67 G68 H69 R83 Y104 E114 E116 W161 K18 R48 K52 C64 G65 H66 R80 Y101 E111 E113 W158 H25 H32 C67 H69 E87 Y104 E114 E116 W161 H22 H29 C64 H66 E84 Y101 E111 E113 W158 5.3.3.2 0000287,0003824,0004452,0005737,0006974,0008270,0008299,0016853,0046872,0050992 Ki=0.12nM Q46822 18391416 1186 EHVILLNAQGVPTGTLEKYAAHTADTRLHLAFSSWLFNAKGQLLVTRRALSKKAWPGVWTNSVCGHPQLGESNEDAVIRRCRYELGVEITPPESIYPDFRYRATDPSGIVENEVCPVFAARTTSALQINDDEVMDYQWCDLADVLHGIDATPWAFSPWMVMQATNREARKRLSAFTQLKL