2vfz A 2.4 BS01 UPF A 1 F134 V136 Y139 I198 S199 R202 D225 V226 D227 H280 A281 A282 D316 E317 K359 F53 V55 Y58 I117 S118 R121 D144 V145 D146 H199 A200 A201 D235 E236 K278 W314 W233 2.4.1.87 0005975,0016020,0016758 Ki=245uM -logKd/Ki=3.61, Ki=245uM P14769 17493636 1360 KLKLSDWFNPFKRPEVVTMTKWKAPVVWEGTYNRAVLDNYYAKQKITVGLTVFAVGRYIEHYLEEFLTSANKHFMVGHPVIFYIMVDDVSRMPLIELGPLRSFKVFKIKPEKRWQDISMMRMKTIGEHIVAHIQHEVDFLFCMDVDQVFQDKFGVETLGESVAQLQAWWYKADPNDFTYERRKESAAYIPFGEGDFYYHAAIFGGTPTQVLNITQECFKGILKDKKNDIEAQWHDESHLNKYFLLNKPTKILSPEYCWDYHIGLPADIKLVKMSWQTK 2vfz A 2.4 BS02 MN A 1 D225 D227 D144 D146 W314 W233 2.4.1.87 0005975,0016020,0016758 P14769 17493636 1361 KLKLSDWFNPFKRPEVVTMTKWKAPVVWEGTYNRAVLDNYYAKQKITVGLTVFAVGRYIEHYLEEFLTSANKHFMVGHPVIFYIMVDDVSRMPLIELGPLRSFKVFKIKPEKRWQDISMMRMKTIGEHIVAHIQHEVDFLFCMDVDQVFQDKFGVETLGESVAQLQAWWYKADPNDFTYERRKESAAYIPFGEGDFYYHAAIFGGTPTQVLNITQECFKGILKDKKNDIEAQWHDESHLNKYFLLNKPTKILSPEYCWDYHIGLPADIKLVKMSWQTK 2vfz B 2.4 BS01 UPF B 1 F1134 A1135 V1136 Y1139 W1195 I1198 S1199 R1202 D1225 V1226 D1227 H1280 A1281 A1282 H1315 D1316 E1317 K1359 F52 A53 V54 Y57 W113 I116 S117 R120 D143 V144 D145 H198 A199 A200 H233 D234 E235 K277 Q1247 H1280 W1314 E1317 W1356 Q165 H198 W232 E235 W274 2.4.1.87 0005975,0016020,0016758 Ki=245uM P14769 17493636 2364 LKLSDWFNPFKRPEVVTMTKWKAPVVWEGTYNRAVLDNYYAKQKITVGLTVFAVGRYIEHYLEEFLTSANKHFMVGHPVIFYIMVDDVSRMPLIELGPLRSFKVFKIKPEKRWQDISMMRMKTIGEHIVAHIQHEVDFLFCMDVDQVFQDKFGVETLGESVAQLQAWWYKADPNDFTYERRKESAAYIPFGEGDFYYHAAIFGGTPTQVLNITQECFKGILKDKKNDIEAQWHDESHLNKYFLLNKPTKILSPEYCWDYHIGLPADIKLVKMSWQTKEYNV 2vfz B 2.4 BS02 MN B 1 D1225 D1227 K1359 D143 D145 K277 Q1247 H1280 W1314 E1317 W1356 Q165 H198 W232 E235 W274 2.4.1.87 0005975,0016020,0016758 P14769 17493636 2365 LKLSDWFNPFKRPEVVTMTKWKAPVVWEGTYNRAVLDNYYAKQKITVGLTVFAVGRYIEHYLEEFLTSANKHFMVGHPVIFYIMVDDVSRMPLIELGPLRSFKVFKIKPEKRWQDISMMRMKTIGEHIVAHIQHEVDFLFCMDVDQVFQDKFGVETLGESVAQLQAWWYKADPNDFTYERRKESAAYIPFGEGDFYYHAAIFGGTPTQVLNITQECFKGILKDKKNDIEAQWHDESHLNKYFLLNKPTKILSPEYCWDYHIGLPADIKLVKMSWQTKEYNV